What Medicinal Chemists Jobs are in the United States?

Our client, a dynamic and innovative biopharmaceutical company dedicated to developing novel therapeutics, is seeking an experienced Senior Medicinal Chemist to join their fully remote research team. This role is critical for the design, synthesis, and optimization of novel small molecule drug candidates targeting unmet medical needs. You will work closely with biologists, pharmacologists, and other chemists to advance programs from hit identification through lead optimization. This is a remote-first position, allowing you to contribute to impactful drug discovery efforts from anywhere, collaborating with a talented, dispersed team.

• Design and synthesize novel small molecules with desired pharmacological profiles using modern synthetic organic chemistry techniques.
• Optimize lead compounds to improve potency, selectivity, pharmacokinetic properties, and reduce toxicity.
• Utilize structure-activity relationship (SAR) data and computational modeling to guide compound design.
• Collaborate closely with biologists, pharmacologists, and DMPK scientists to interpret data and define project priorities.
• Plan and execute multi-step synthetic routes, troubleshoot synthetic challenges, and ensure timely delivery of high-quality compounds.
• Stay current with the latest advancements in medicinal chemistry, synthetic methodology, and drug discovery technologies.
• Contribute to the development of intellectual property through patent filings.
• Document experimental procedures, results, and conclusions meticulously in electronic laboratory notebooks and reports.
• Present research findings at internal project team meetings and potentially at external scientific conferences.
• Mentor junior chemists and contribute to a culture of scientific excellence and collaboration.

• Ph.D. in Organic Chemistry, Medicinal Chemistry, or a closely related field.
• A minimum of 6 years of hands-on experience in medicinal chemistry within the pharmaceutical or biotechnology industry.
• Proven track record of successfully contributing to the discovery and optimization of small molecule drug candidates.
• Extensive experience in synthetic organic chemistry, including route design, execution, and troubleshooting.
• Strong understanding of medicinal chemistry principles, including SAR analysis, ADMET properties, and drug design strategies.
• Familiarity with computational chemistry tools and techniques for molecular modeling and virtual screening is desirable.
• Excellent problem-solving skills, creativity, and strong experimental design capabilities.
• Exceptional written and verbal communication skills, with the ability to present complex scientific information clearly.
• Proficiency in managing multiple projects simultaneously and working effectively in a virtual team environment.
• Demonstrated ability to work independently and as a collaborative team member.

This is a fully remote role offering excellent flexibility. Our client provides a highly competitive salary, bonus opportunities, and a comprehensive benefits package including health, dental, and vision insurance, a 401(k) with company match, and generous paid time off. They offer a significant budget for professional development, home office equipment, and continuous learning. The company culture emphasizes innovation, collaboration, and work-life balance, making this a unique opportunity to drive drug discovery forward remotely.

Our client, a prominent pharmaceutical company dedicated to developing novel therapies, is seeking a highly accomplished Principal Medicinal Chemist to join their esteemed research team in Madison, Wisconsin, US . This senior-level position plays a crucial role in the design and synthesis of novel small molecule drug candidates targeting unmet medical needs. You will be instrumental in driving discovery projects from initial hit identification through to lead optimization, contributing significantly to the company's drug development pipeline. The ideal candidate will possess a deep understanding of structure-activity relationships (SAR), synthetic organic chemistry, and drug design principles, coupled with extensive experience in the pharmaceutical industry. This role demands creativity, strategic thinking, and a passion for innovation in drug discovery. You will work in a state-of-the-art research facility, collaborating closely with biologists, pharmacologists, and computational chemists to achieve project goals. The opportunity to lead complex medicinal chemistry efforts and mentor junior scientists makes this a highly rewarding position for an experienced chemist seeking to make a significant impact.

• Lead the design, synthesis, and optimization of novel small molecule drug candidates using modern medicinal chemistry strategies.
• Develop structure-activity relationships (SAR) and structure-property relationships (SPR) to guide compound optimization.
• Collaborate closely with biology and DMPK teams to establish and execute iterative design-synthesize-test cycles.
• Utilize computational chemistry tools and techniques to support rational drug design efforts.
• Independently plan and execute complex multi-step synthetic routes for target molecules.
• Critically evaluate synthetic feasibility, potential liabilities, and strategic direction of medicinal chemistry projects.
• Mentor and guide junior medicinal chemists and research associates, fostering a culture of scientific excellence.
• Prepare high-quality scientific reports, patent applications, and research publications.
• Present research findings effectively to internal project teams, steering committees, and at scientific conferences.
• Stay current with the latest advancements in medicinal chemistry, synthetic methodology, and relevant therapeutic areas.

• Ph.D. in Organic Chemistry or Medicinal Chemistry.
• Minimum of 7 years of hands-on medicinal chemistry experience in the pharmaceutical or biotechnology industry.
• Demonstrated success in leading medicinal chemistry programs and contributing to compounds that have advanced into preclinical or clinical development.
• Expertise in modern synthetic organic chemistry, including route design and optimization.
• Strong understanding of drug discovery principles, pharmacokinetics, and drug metabolism.
• Proficiency in using structure-based drug design (SBDD) and computational chemistry tools.
• Excellent track record of scientific contributions, including patents and publications.
• Proven ability to lead and mentor research teams.
• Exceptional problem-solving skills and the ability to think critically and creatively.
• Strong presentation and communication skills, with the ability to articulate complex scientific concepts clearly.

• Highly competitive salary and annual bonus potential.
• Generous equity/stock options package.
• Comprehensive health, dental, and vision insurance plans.
• 401(k) plan with employer matching contributions.
• Significant paid time off and company holidays.
• Support for professional development, including conference attendance and training.
• Access to cutting-edge research technologies and facilities.
• Relocation assistance for qualified candidates.
• A dynamic and science-driven work environment.

• Lead medicinal chemistry efforts for drug discovery projects, from hit identification through lead optimization.
• Design and synthesize novel small molecule drug candidates using modern synthetic organic chemistry techniques.
• Develop and iteratively refine structure-activity relationships (SAR) to improve potency, selectivity, and pharmacokinetic properties.
• Collaborate closely with biologists to design and interpret bioassays for compound evaluation.
• Work with DMPK and toxicology teams to assess and optimize ADME properties and safety profiles.
• Manage project timelines, resources, and delegate tasks to junior chemists.
• Stay abreast of the latest advances in medicinal chemistry and relevant therapeutic areas.
• Present research findings and strategic recommendations to project teams and senior management.
• Contribute to patent applications and scientific publications.
• Foster a collaborative and innovative research environment.

• Ph.D. in Organic Chemistry or Medicinal Chemistry.
• A minimum of 6 years of post-doctoral or industry experience in drug discovery.
• Proven track record of successfully contributing to the advancement of small molecule drug candidates.
• Extensive expertise in synthetic organic chemistry, including asymmetric synthesis and heterocyclic chemistry.
• Strong understanding of SAR principles, molecular modeling, and bioisosteric replacement.
• Experience with ADME/PK optimization and understanding of drug metabolism and transporter mechanisms.
• Excellent problem-solving, analytical, and critical thinking skills.
• Strong leadership and mentoring capabilities.
• Excellent written and verbal communication skills.
• Ability to work effectively in a multidisciplinary team and manage projects in **Portland, Oregon**.

Our client, a groundbreaking pharmaceutical company dedicated to discovering novel therapeutics, is seeking a talented and innovative Senior Medicinal Chemist to join their research team in Oklahoma City, Oklahoma . This role is pivotal in driving the early-stage drug discovery process, focusing on the design, synthesis, and optimization of small molecule drug candidates. The Senior Medicinal Chemist will collaborate closely with biologists and other scientists to identify and advance promising compounds through the discovery pipeline. The ideal candidate possesses a strong background in synthetic organic chemistry, a deep understanding of structure-activity relationships (SAR), and a passion for creating new medicines. This is an exceptional opportunity to contribute to cutting-edge research and development within a collaborative and scientifically stimulating environment.

• Design and synthesize novel small molecule compounds for therapeutic targets, employing modern synthetic organic chemistry techniques.
• Conduct structure-activity relationship (SAR) studies to optimize lead compounds for potency, selectivity, and pharmacokinetic properties.
• Plan and execute multi-step synthesis routes, troubleshoot synthetic challenges, and ensure the purity and characterization of synthesized compounds.
• Collaborate with biologists and pharmacologists to evaluate the biological activity of synthesized compounds and integrate feedback into design strategies.
• Work effectively in a hybrid environment, contributing both independently on synthesis projects and collaborating with team members on-site and virtually.
• Maintain detailed laboratory notebooks and prepare scientific reports summarizing synthetic efforts and findings.
• Stay current with the latest advances in medicinal chemistry, synthetic methodology, and drug discovery trends.
• Contribute to intellectual property generation through patent applications.
• May involve occasional on-site laboratory work requiring hands-on synthesis and collaborative discussions.

• PhD in Organic Chemistry or Medicinal Chemistry.
• Minimum of 5 years of relevant experience in medicinal chemistry within the pharmaceutical or biotechnology industry.
• Proven track record in the design and synthesis of small molecule drug candidates.
• Expertise in modern synthetic organic chemistry, including reaction optimization, purification techniques (e.g., chromatography), and compound characterization (e.g., NMR, Mass Spectrometry, HPLC).
• Strong understanding of SAR principles and their application in drug discovery programs.
• Excellent problem-solving skills and ability to work independently and as part of a team.
• Effective written and verbal communication skills for scientific reporting and collaboration.
• Experience working in a hybrid setup, balancing remote research planning with necessary on-site laboratory activities in Oklahoma City, Oklahoma .

Our client offers a competitive salary commensurate with experience, coupled with a comprehensive benefits package. This includes health, dental, and vision insurance, a 401(k) retirement savings plan with company match, and generous paid time off. Employees benefit from opportunities for professional growth, training, and the chance to contribute to meaningful scientific advancements. This hybrid role provides flexibility while ensuring crucial on-site laboratory contributions to drug discovery efforts.

• Lead the design and synthesis of novel small molecule drug candidates targeting key disease pathways.
• Collaborate with biologists to define target product profiles and establish SAR for identified hits and leads.
• Develop and execute synthetic routes for complex molecules, ensuring scalability and efficiency.
• Utilize computational chemistry tools and structural biology data to guide molecular design.
• Work closely with DMPK and toxicology teams to optimize pharmacokinetic and safety profiles.
• Present research findings and strategic recommendations to project teams and senior leadership.
• Mentor and guide junior chemists within the drug discovery team.
• Maintain comprehensive records of experimental procedures, results, and intellectual property.
• Actively contribute to the intellectual property portfolio through patent filings.

• Ph.D. in Organic Chemistry or Medicinal Chemistry with a strong publication record.
• 10+ years of experience in medicinal chemistry within the pharmaceutical or biotechnology industry, with a proven track record of delivering clinical candidates.
• Extensive experience in synthetic organic chemistry, including multi-step synthesis of complex molecules.
• Deep understanding of SAR, ADME/Tox principles, and drug design strategies.
• Proficiency with molecular modeling and visualization software.
• Excellent interpersonal and communication skills, essential for effective remote collaboration.
• Demonstrated leadership abilities and experience mentoring scientific staff.
• Ability to manage multiple projects simultaneously and prioritize effectively in a fast-paced environment.
• Strong problem-solving skills and a creative approach to synthetic challenges.

• Design novel small molecule drug candidates using computational chemistry and medicinal chemistry principles.
• Utilize structure-based drug design (SBDD) and ligand-based drug design (LBDD) methodologies.
• Perform molecular modeling, virtual screening, and docking studies.
• Develop and apply quantitative structure-activity relationship (QSAR) models.
• Collaborate closely with medicinal chemists, biologists, and pharmacologists to guide iterative design cycles.
• Analyze and interpret complex datasets to optimize compound properties, including potency, selectivity, and ADMET.
• Stay abreast of the latest advancements in computational chemistry and drug discovery techniques.
• Mentor junior computational chemists and contribute to team strategy.

• Ph.D. in Computational Chemistry, Medicinal Chemistry, Cheminformatics, or a related field.
• Minimum of 6 years of experience in computational chemistry and drug design within the pharmaceutical industry.
• Proficiency in molecular modeling software (e.g., Schrodinger Suite, MOE, Discovery Studio).
• Strong experience with virtual screening, docking, molecular dynamics, and QSAR.
• Expertise in programming languages such as Python for scripting and data analysis.
• Excellent understanding of medicinal chemistry principles and drug discovery processes.
• Demonstrated ability to work effectively in cross-functional teams in a **Salt Lake City**-based research setting.
• Strong communication, presentation, and problem-solving skills.

• Design and synthesize novel small molecules with desirable pharmacological properties for oncology targets.
• Optimize lead compounds through iterative cycles of design, synthesis, and biological testing.
• Collaborate closely with biologists, pharmacologists, and DMPK scientists to define structure-activity relationships (SAR) and structure-property relationships (SPR).
• Utilize advanced synthetic methodologies and purification techniques to prepare complex organic molecules.
• Manage outsourced synthesis projects and maintain excellent communication with external chemistry CROs.
• Characterize synthesized compounds using analytical techniques such as NMR, LC-MS, and HPLC.
• Contribute to intellectual property generation through patent filings.
• Stay current with the latest advancements in synthetic organic chemistry and medicinal chemistry, particularly in oncology drug discovery.

• Ph.D. in Organic Chemistry or Medicinal Chemistry.
• Minimum of 4 years of post-doctoral or industry experience in medicinal chemistry, with a strong focus on small molecule drug discovery.
• Demonstrated success in designing and synthesizing novel compounds, ideally in the oncology space.
• Extensive experience with a wide range of modern synthetic organic chemistry techniques.
• Proficiency in structure-based drug design and SAR analysis.
• Experience with analytical characterization techniques (NMR, LC-MS, HPLC).
• Strong problem-solving skills and the ability to work independently and collaboratively.
• Excellent written and verbal communication skills.
• Must be legally authorized to work in the United States.

C4 Therapeutics-Inc is looking for a Principal Scientist in Medicinal Chemistry to join their Watertown, MA team. This role demands a creative medicinal chemist with a PhD and at least eight years of relevant experience in biopharmaceutical or pharmaceutical settings.

The successful candidate will lead efforts in developing targeted protein degradation therapeutics, ensuring collaboration across multiple scientific disciplines while advancing small molecules through critical project milestones.

Competitive salary range of $181,012.05 - $200,066.00 annually offered, commensurate with experience.