What Principal Applications Architect Jobs are in the United States?

Job Summary

We are seeking an experienced Senior Principal Applications Engineer – Mass Spectrometry to provide advanced technical leadership in the development, optimization, and deployment of mass spectrometry applications. The ideal candidate will have strong expertise in analytical instrumentation, application development, customer support, and technical problem‑solving.

This role involves collaborating with customers, engineering teams, product management, and R&D teams to deliver innovative mass spectrometry solutions, improve application performance, and support complex scientific workflows.

Key Responsibilities

Provide advanced technical expertise and leadership for mass spectrometry applications and workflows.

Develop, optimize, and validate analytical methods using LC‑MS, GC‑MS, and high‑resolution mass spectrometry platforms.

Lead customer engagements including technical demonstrations, proof‑of‑concepts, troubleshooting, and application support.

Analyze complex analytical data and provide recommendations for workflow improvements.

Collaborate with R&D, engineering, and product teams on product enhancements and new application development.

Support instrument evaluation, testing, validation, and performance optimization.

Create technical documentation, application notes, training materials, and best practice guides.

Mentor junior engineers and provide technical guidance across application teams.

Identify customer challenges and translate requirements into effective technical solutions.

Support field teams with advanced troubleshooting and customer escalations.

Stay current with emerging technologies and industry trends in mass spectrometry and analytical sciences.

Required Qualifications

Bachelor’s or Master’s degree in Chemistry, Biochemistry, Life Sciences, Engineering, Computer Science, or related technical discipline.

6–12 years of experience in Mass Spectrometry applications, analytical instrumentation, or scientific technology solutions.

Strong hands‑on experience with LC‑MS, GC‑MS, and mass spectrometry workflows.

Expertise in method development, optimization, validation, and analytical troubleshooting.

Strong understanding of mass spectrometry principles, instrumentation, and data interpretation.

Experience working with cross‑functional teams including engineering, R&D, product management, and customers.

Excellent communication, technical presentation, and problem‑solving skills.

Preferred Skills

Experience with high‑resolution mass spectrometry (HRMS) platforms.

Knowledge of proteomics, metabolomics, pharmaceutical, biotechnology, or clinical research applications.

Experience with mass spectrometry data processing and analysis software.

Familiarity with laboratory workflows, automation, and scientific informatics systems.

Experience supporting enterprise customers, technical sales, or field applications engineering.

Leadership experience mentoring engineers or technical teams.

Technical Skills

• Mass Spectrometry (MS)
• LC‑MS / GC‑MS
• High Resolution Mass Spectrometry (HRMS)
• Analytical Method Development
• Instrument Optimization & Troubleshooting
• Scientific Data Analysis
• Laboratory Instrumentation
• Application Engineering
• Technical Documentation
• Scientific Software Platforms

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Job Summary:
This senior technical expert drives enterprise Content Management System (CMS) strategy and leads the evolution of Adobe Experience Manager (AEM) use with proven ability to influence architecture and platform strategy in complex enterprise environments. Partnering with application and product teams, this role delivers scalable, secure, and high-performing digital solutions across cloud, CMS, digital marketing, content supply chain, workflow automation, DAM, and integration ecosystems. Provides architectural leadership and advisory support while ensuring platform reliability with and continuous improvement initiatives, incident management, and root cause analysis. Contributes to standards lifecycle management, governance processes, and reference architectures that guide solution design and investment decisions. Oversees CDN/NGINX configurations and automation to enable efficient, secure operations. Partners across architecture, engineering, security, infrastructure, and delivery teams to ensures alignment with strategic objectives, enforce architecture governance, define enterprise standards, and ensure effective balance between governance, operational excellence, risk management, and delivery efficiency.
This senior level employee is primarily responsible for influencing and leveraging the technical direction of integrated business and/or enterprise application solutions and for serving as an expert for technical teams. This employee is accountable for ensuring software solutions are managed with full adherence to industry best practices.
Essential Responsibilities:
+ Drives the execution of multiple work streams by identifying customer and operational needs; developing and updating new procedures and policies; gaining cross-functional support for objectives and priorities; translating business strategy into actionable business requirements; obtaining and distributing resources; setting standards and measuring progress; removing obstacles that impact performance; guiding performance and developing contingency plans accordingly; solving highly complex issues; and influencing the completion of project tasks by others.
+ Practices self-leadership and promotes learning in others by soliciting and acting on performance feedback; building collaborative, cross-functional relationships; communicating information and providing advice to drive projects forward; adapting to competing demands and new responsibilities; providing feedback to others, including upward feedback to leadership; influencing, mentoring, and coaching team members; fostering open dialogue amongst team members; evaluating and responding to the strengths and weaknesses of self and unit members; and adapting to and learning from change, difficulties, and feedback.
+ Provides insight into recommendations for complex technical solutions that meet design and functional needs.
+ Serves as an expert for innovative technical solutions that meet design and functional needs.
+ Collaborates with architects and/or software consultants to ensure functional specifications are converted into flexible, scalable, and maintainable solution designs.
+ Provides technical expertise for the development, configuration, or modification of integrated business and/or enterprise application solutions within various computing environments by providing insight, guidance, and an escalation point for the design and coding of component-based applications.
+ Translates business requirements and functional specifications into physical program designs, code modules, stable application systems, and software solutions by partnering with Business Analysts and other team members to understand business needs and functional specifications.
+ Leverages networks to drive collaboration between technical teams, architects, and/or software consultants, and ensure functional specifications are converted into flexible, scalable, and maintainable solution designs.
+ Builds and maintains trusting relationships with internal customers, third party vendors, and senior management to ensure the alignment, buy-in, and support of diverse project stakeholders.
+ Oversees the review and implementation of recommendations of technical solutions across multiple functions.
+ Takes accountability for ensuring specific interfaces, methods, parameters, procedures, and functions support technical solutions and are aligned with architectural designs.
+ Derives an overall strategy of data management, within an established Information Architecture, that supports the business model. Identifies information structures and detail to enable the development and secure operation of new information services. Takes overall responsibility for planning effective information storage, sharing, and publishing within the organization.
+ Sets strategies for effective use of database technology taking account of the complex interrelations between hardware/software. Provides specialist expertise in the development, use, or operation of database management system tools and facilities. Provides expert knowledge in the selection, provision, and use of database architectures, software, and facilities, typically taking responsibility for a team of technical staff.
+ Facilitates and serves as a technical expert for project teams throughout the release schedule of business and enterprise software solutions.
+ Provides expertise and guidance to team members for systems incident responses for complex issues.
+ Fosters and leverages partnerships with IT teams and vendors to ensure written code adheres to company architectural standards, design patterns, and technical specification.
+ Maintains and enhances technical expertise and knowledge of industry trends by attending participating conferences, and developing a network with other IT industry experts.
+ Leads consultation efforts to help ensure new and existing software solutions are developed with insight into industry best practices, strategies, and architectures.
+ Provides expert technical advice and recommendations to others within the organization on matters related to software engineering, including market trends, and new programs and applications.
+ Reviews and verifies resource estimates for complex technical design, coding, and testing efforts.
+ Identifies specific interfaces, methods, parameters, procedures, and functions, as required, to support technical solutions, serving as an escalation point for complex or unresolved issues related to requirements translation.
+ As part of the IT Engineering job family, this position is responsible for leveraging DEVOPS, and both Waterfall and Agile practices, to design, develop, and deliver resilient, secure, multi-channel, high-volume, high-transaction, on/off-premise, cloud-based solutions.
Knowledge, Skills and Abilities: (Core)
+ Ambiguity/Uncertainty Management
+ Attention to Detail
+ Business Knowledge
+ Communication
+ Critical Thinking
+ Cross-Group Collaboration
+ Decision Making
+ Dependability
+ Diversity, Equity, and Inclusion Support
+ Drives Results
+ Facilitation Skills
+ Health Care Industry
+ Influencing Others
+ Integrity
+ Learning Agility
+ Organizational Savvy
+ Problem Solving
+ Short- and Long-term Learning & Recall
+ Strategic Thinking
+ Teamwork
+ Topic-Specific Communication
Knowledge, Skills and Abilities: (Functional)
+ Acts with Compassion
+ Analytical Skills
+ Application Delivery Process
+ Application Design, Architecture
+ Application Maintenance
+ Application Testing
+ Client Focus
+ Client/Server Tools
+ Crisis Incident Management
+ Debugging and Troubleshooting
+ Demonstrating Personal Flexibility
+ Getting Work Done Through Others
+ IT Industry: Trends & Directions
+ Innovative Mindset
+ Managing Diverse Relationships
+ Microsoft Office
+ Organizational Skills
+ Prioritization
+ Product Development Life Cycle
+ Relational Database Management
+ Relationship Building
+ Requirements Elicitation & Analysis
+ SQL/SAS
+ Software Development Life Cycle
+ System Testing
+ Technical Communication
Minimum Qualifications:
+ Minimum six (6) years experience working on project(s) involving the implementation of solutions applying development life cycles (e.g., SDLC).
+ Minimum four (4) years in a technical leadership role with or without direct reports.
+ Bachelors degree in Computer Science, CIS, or related field and Minimum ten (10) years experience in software development or a related field. Additional equivalent work experience may be substituted for the degree requirement.
Preferred Qualifications:
+ Four (4) years of development experience with Node.js
+ Four (4) years of development experience with Oracle
COMPANY: KAISER
TITLE: Principal Applications Engineer, AEM Platform (Greensboro, NC)
LOCATION: Greensboro, North Carolina
REQNUMBER:
External hires must pass a background check/drug screen. Qualified applicants with arrest and/or conviction records will be considered for employment in a manner consistent with Federal, state and local laws, including but not limited to the San Francisco Fair Chance Ordinance. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, protected veteran, or disability status.

About the Role Our client, a leader in its industry, is seeking an experienced Principal Application Architect to join their team in **Milwaukee, Wisconsin**. This role is critical for designing and overseeing the development of enterprise-level applications that drive business innovation and efficiency. You will be responsible for defining application architecture strategies, establishing development standards, and ensuring the scalability, reliability, and maintainability of our client's software portfolio. The ideal candidate is a seasoned technical leader with a strong understanding of modern software design principles and a passion for building high-quality applications. This role requires a strong on-site presence for collaborative development and technical leadership. Key Responsibilities

• Design and architect robust, scalable, and maintainable enterprise applications.
• Define application architecture strategies, patterns, and best practices.
• Collaborate with product owners, business analysts, and development teams to gather requirements and design solutions.
• Provide technical leadership and mentorship to application development teams.
• Evaluate and select appropriate technologies, frameworks, and tools for application development.
• Ensure adherence to coding standards, security policies, and performance requirements.
• Oversee the integration of applications with other enterprise systems.
• Troubleshoot and resolve complex technical challenges within the application landscape.

Requirements

• Master's degree in Computer Science, Software Engineering, or a related field.
• 10+ years of experience in software development, with at least 5 years in an application architecture role.
• Proven experience designing and delivering complex, large-scale enterprise applications.
• Expertise in various programming languages (e.g., Java, C#, Python) and frameworks.
• Strong understanding of microservices, APIs, service-oriented architecture (SOA), and web technologies.
• Experience with cloud environments (AWS, Azure, GCP) and containerization technologies (Docker, Kubernetes).
• Excellent problem-solving, analytical, and strategic thinking abilities.
• Strong communication and leadership skills, with the ability to influence technical decisions.

Benefits Our client offers a competitive salary, comprehensive benefits package including health, dental, and vision insurance, a 401(k) plan with employer match, ample paid time off, and significant opportunities for professional growth and learning. Become a key contributor to our technology initiatives in **Milwaukee, Wisconsin**.

NXP’s SerDes Networking Solution (SNS) team delivers open-standard Automotive SerDes Alliance (ASA) Motion Link multi‑Gigabit connectivity for next‑generation sensors and vehicle displays. As part of the Applications Engineering team, you will work with both internal engineering teams to develop collaterals to ease customer adoption of our SerDes solutions, as well as with NXP’s field teams and customer engineering teams to ensure successful system design and bring‑up.

Key Responsibilities

• Collaborate with IC design, systems, FW, and test teams to translate field issues and customer requirements into product improvements and new features.
• Review customer schematics and layouts for signal‑integrity and power‑integrity best practices (impedance control, terminations, return paths, via design, reference plane strategy).
• Lead board‑level bring‑up and validation using oscilloscopes, protocol analyzers; generate test reports and recommendations.
• Provide on‑site or remote debug support for complex customer issues.
• Develop and maintain application collateral: reference designs, layout guidelines, design checklists, characterization reports, application notes, training materials.
• Participate in trade shows and provide FAE training.

Qualifications

• Bachelor’s degree or above in Electrical/Electronic Engineering or related field.
• Extensive experience (12+ years) in hardware design, applications engineering, or system validation.
• Familiarity with high‑speed data communication protocols and interfaces, including Ethernet networking and switching, MIPI CSI‑2, and display protocols (DP/eDP).
• Strong understanding of high‑speed SerDes fundamentals: channel loss, reflections, return loss, insertion loss, ISI, jitter, equalization, and clocking.
• Demonstrated experience with multi‑Gbps serial links (e.g., Ethernet, PCIe, DP, USB3.x/USB4, proprietary SerDes).
• Proficiency with SI/PI tools and simulations (e.g., S‑parameter analysis, eye/jitter simulations) and comfort interpreting simulation and measurement correlation.
• Hands‑on experience using lab equipment: high‑bandwidth oscilloscopes, TDR, VNA, BERT, protocol analyzers, logic analyzers, and related tools.
• Strong skills in PCB design for high‑speed: layer stack‑up, routing constraints, differential pairs, reference planes, decoupling, and power delivery.
• Excellent communication and presentation skills to explain complex technical topics to both expert and non‑expert audiences.
• Ability to work effectively with global, cross‑functional teams (design, systems, test, marketing, field).

The base salary range for this position is as mentioned below per year. We also provide competitive benefits, incentive compensation, and/or equity for certain roles.
Company benefits include health, dental, and vision insurance, 401(k), and paid leave. Please note that the base salary range (or hourly rate) is a guideline, and individual total compensation may vary based on a number of factors such as qualifications, skill level, work location, and other business and organizational needs. This base pay range is specific to California and is not applicable to other locations. A reasonable estimate of the base salary range as of the date of this posting is:

$186,200 to $256,100 annually

More information about NXP in the United States…

NXP is an Equal Opportunity/Affirmative Action Employer regardless of age, color, national origin, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, marital status, status as a disabled veteran and/or veteran of the Vietnam Era or any other characteristic protected by federal, state or local law. In addition, NXP will provide reasonable accommodations for otherwise qualified disabled individuals.

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Job Description

• Job title: Senior Principal Applications Engineer
• Experience: 5-14 Years
• Location: Milpitas, USA
• Job Type: Full-time

Must Haves

• Experience in analytical instrumentation e.g. Mass spectrometers and gas analyzers.
• Familiarity with semiconductor manufacturing processes
• Self- motivated and constantly engaging with customers.

Qualifications

• M.Sc. degree with 6+ years' work experience or Ph.D. with 2+ yrs. Work experience in Physics, Chemistry, Electrical Engineering, or a related field.
• 5+ years hands-on experience with the development of mass-spectrometry based solutions for novel applications.
• Experience with analytical instruments such as mass spectrometers, gas analyzers, or plasma diagnostics
• Familiarity with semiconductor manufacturing processes (etch, CVD, ALD).
• Sound understanding of the new product introduction process, including the definition of new product requirements, prototypes evaluation, and ability to diagnose and debug systems level issues.
• Proven success in delivering customer-facing presentations and conducting pre-sale product demonstrations.

Key Responsibilities

• Develop intricate operational knowledge of MS products under development.
• Provide hands-on experience with instrument configuration, calibration, validation, and performance testing.
• Develop new market-driven applications in concert with potential customers.
• Support Aston evaluations at semiconductor OEMs and fabs.
• Provide on-site setup, debug, and performance analysis of Aston systems.
• Identify key application-specific requirements early in the customer engagements process
• Develop application-specific Aston solution bundles based on tailored HW and SW features
• Develop a support plan and an execution timeline for key customer engagements
• Strengthen key customer relations through technical competence and relationship management skills.
• Identify new application opportunities and write internal or customer-facing proposals
• Deliver customer-facing presentations and conduct pre-sale product demonstrations.
• Develop and deliver HW/SW-related operational training sessions to customers.
• Acquire and analyze samples from prospective customers and provide sample analysis data reports to actively close sales opportunities.

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NXP Semiconductors’ SerDes Networking Solution (SNS) team is seeking a senior hardware engineer to translate field requirements into product improvements, lead board bring-up, and deliver application collateral. Based in California, you will collaborate across IC design, systems, firmware, and test teams to ensure successful design and bring-up of multi-Gbps links.

Applicants should have a Bachelor's in Electrical Engineering and 12+ years of experience, with deep knowledge of Ethernet, PCIe,

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Senior Principal Applications Engineer – Mass Spectrometry Position summary

The successful Senior Applications engineer candidate will report to the Director of Applications and will work closely with other functions of the company, including business development, marketing, sales, and engineering. The Senior Applications engineer is responsible for leading the development efforts of application-specific solutions around Aston; the company’s flagship product. The engineer is expected to play a major role in leading technical engagements with customers in the area semiconductor manufacturing and its vertical applications, preparing and presenting customer‑facing material, contributing to product roadmaps, and supporting new product definition and introduction.

Responsibilities

• Develop intricate operational knowledge of MS products under development.
• Provide hands‑on experience with instrument configuration, calibration, validation, and performance testing.
• Develop new market‑driven applications in concert with potential customers.
• Support Aston evaluations at semiconductor OEMs and fabs.
• Provide on‑site setup, debug, and performance analysis of Aston systems.
• Identify key application‑specific requirements early in the customer engagements process.
• Develop application‑specific Aston solution bundles based on tailored HW and SW features.
• Develop a support plan and an execution timeline for key customer engagements.
• Strengthen key customer relations through technical competence and relationship management skills.
• Identify new application opportunities and write internal or customer‑facing proposals.
• Deliver customer‑facing presentations and conduct pre‑sale product demonstrations.
• Develop and deliver HW/SW‑related operational training sessions to customers.
• Acquire and analyze samples from prospective customers and provide sample analysis data reports to actively close sales opportunities.
• Contribute to and support definitions of next generation product roadmaps.
• Contribute to product development efforts by breaking down system specifications into component performance requirements and participate in the development review process.

Requirements

• M.Sc. degree with 6+ years’ work experience or Ph.D. with 2+ yrs. work experience in Physics, Chemistry, Electrical Engineering, or a related field.
• 5+ years hands‑on experience with the development of mass‑spectrometry based solutions for novel applications.
• Experience with analytical instruments such as mass spectrometers, gas analyzers, or plasma diagnostics.
• Familiarity with semiconductor manufacturing processes (etch, CVD, ALD).
• Sound understanding of the new product introduction process, including the definition of new product requirements, prototype evaluation, and ability to diagnose and debug systems‑level issues.
• Proven success in delivering customer‑facing presentations and conducting pre‑sale product demonstrations.
• Excellent written and verbal communication skills.
• Knowledge of control hardware (e.g., PLC) and software scripting using platforms such as Python and Lab‑view is desirable.
• Up to 30% domestic and international travel expectations.

Preferred Skills

• Self‑motivated and comfortable working in early‑stage or dynamic environments.
• Strong team‑building personality and collaborative mindset.

Performance Metrics per Agreed Upon KPIs

• Excellence in managing customer relationships.
• Achieving high customer satisfaction.
• Achieving high rate of successful Aston evaluations.

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Senior Principal Applications Engineer - Mass Spectrometry 86003

Cephas Consultancy Services Private Limited Milpitas, California United States

About this position

Positions: 1 Full Time. Experience 6 - 12 Years.

Job Description

Position summary:

The successful Senior Applications engineer candidate will report to the Director of Applications and will work closely with other functions of the company, including business development, marketing, sales, and engineering. The Senior Applications engineer is responsible for leading the development efforts of application-specific solutions around Aston; the company’s flagship product. The engineer is expected to play a major role in leading technical engagements with customers in the area semiconductor manufacturing and its vertical applications, preparing and presenting customer-facing material, contributing to product roadmaps, and supporting new product definition and introduction.

Responsibilities

• Develop intricate operational knowledge of MS products under development.
• Provide hands‑on experience with instrument configuration, calibration, validation, and performance testing.
• Develop new market‑driven applications in concert with potential customers.
• Support Aston evaluations at semiconductor OEMs and fabs.
• Provide on‑site setup, debug, and performance analysis of Aston systems.
• Identify key application‑specific requirements early in the customer engagement process.
• Develop application‑specific Aston solution bundles based on tailored HW and SW features.
• Develop a support plan and an execution timeline for key customer engagements.
• Strengthen key customer relations through technical competence and relationship management skills.
• Identify new application opportunities and write internal or customer‑facing proposals.
• Deliver customer‑facing presentations and conduct pre‑sale product demonstrations.
• Develop and deliver HW/SW‑related operational training sessions to customers.
• Acquire and analyze samples from prospective customers and provide sample analysis data reports to actively close sales opportunities.
• Contribute to and support definitions of next generation product roadmaps.
• Contribute to product development efforts by breaking down system specifications into component performance requirements and participate in the development review process.

Requirements

• M.Sc. degree with 6+ years’ work experience or Ph.D. with 2+ years of Work experience in Physics, Chemistry, Electrical Engineering, or a related field.
• 5+ years hands‑on experience with the development of mass‑spectrometry based solutions for novel applications.
• Experience with analytical instruments such as mass spectrometers, gas analyzers, or plasma diagnostics.
• Familiarity with semiconductor manufacturing processes (etch, CVD, ALD).
• Sound understanding of the new product introduction process, including the definition of new product requirements, prototypes evaluation, and ability to diagnose and debug systems level issues.
• Proven success in delivering customer‑facing presentations and conducting pre‑sale product demonstrations.
• Excellent written and verbal communication skills.
• Knowledge of control hardware e.g. PLC and software scripting using platforms e.g. Python and Lab-view is desirable.
• Up to 30% domestic and international travel expectations.

Preferred Skills

• Self‑motivated and comfortable working in early‑stage or dynamic environments.
• Strong team‑building personality and collaborative mindset.

Performance Metrics per Agreed Upon KPIs

• Excellence in managing customer relationships.
• Achieving high customer satisfaction.
• Achieving high rate of successful Aston evaluations.

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Principal Application Architect with DICOM or Medical Imaging

Job Title: Principal Application Architect with DICOM or Medical Imaging

Type of Employment: Full-time

What’s in it for you:

As Application Architect, you will lead the technical design and implementation of next-generation image viewing and annotation solutions for healthcare.

Key Responsibilities

• Technical design of the future vision
• Architect and implement image viewing and annotation solutions for medical imaging
• Optimize performance for large-scale image rendering and annotation workflows
• Logging, Audits, Versioning
• Gen AI integration and LLM usage for intelligent workflows & conversational analytics

Required Skills & Experience

• 15 years of experience
• Extensive experience on how DICOM viewers work, result generation, results fed back into the system i.e. loop cycle
• Extensive experience on Annotations, Overlays
• Understanding of Zero foot-print viewer
• Extensive experience on OHIF viewers v2 and v3
• Experience developing Digital Pathology viewers
• Extensive experience on DICOM web protocol
• Extensive experience working with Angular / React, .net / java / python, relational / non-relational databases
• Knowledge of imaging standards e.g. DICOM, NIFTI
• Worked in radiology & digital pathology
• Worked in ophthalmology / neurology / oncology disease areas
• Understanding of healthcare interoperability

Recruiter Details:

Email:

Seniority Level

• Director

Employment Type

• Full-time

Job Function

• Information Technology

Industries

• IT Services and IT Consulting
• Medical Equipment Manufacturing

San Francisco, CA

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