15 Lam Research jobs in Fremont
Director of Pharmaceutical Research & Development
Posted 6 days ago
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Job Description
Responsibilities:
- Define and execute the strategic vision for pharmaceutical R&D programs.
- Oversee all aspects of drug discovery and pre-clinical development, from target validation to IND-enabling studies.
- Manage and mentor a diverse team of scientists and research associates.
- Develop and manage R&D budgets, resources, and project timelines.
- Ensure compliance with global regulatory requirements (FDA, EMA, etc.).
- Collaborate with external partners, CROs, and academic institutions.
- Identify and evaluate new scientific opportunities and technologies.
- Drive the preparation of regulatory submissions (e.g., IND, CTA).
- Foster a culture of innovation, collaboration, and scientific rigor.
- Present research findings and strategic plans to senior management and the Board of Directors.
- Stay current with scientific literature, industry trends, and competitive intelligence.
- Contribute to the development of intellectual property strategies.
- Ph.D. in Pharmacology, Molecular Biology, Biochemistry, or a related life sciences discipline.
- 12+ years of progressive experience in pharmaceutical R&D, with at least 5 years in a senior leadership role.
- Extensive experience in small molecule and/or biologic drug discovery and development.
- Proven track record of successfully advancing drug candidates through IND submission.
- Deep understanding of drug development pathways, CMC, toxicology, and clinical study design.
- Strong knowledge of regulatory affairs and submission processes.
- Exceptional leadership, team management, and communication skills.
- Experience with remote team management and virtual collaboration tools.
- Demonstrated ability to think strategically and make data-driven decisions.
- Strong network within the pharmaceutical and biotechnology industry.
- Must be legally authorized to work in the San Jose, California, US area for potential critical in-person meetings or leadership retreats.
Specialized Tax Services - Research & Development Tax - Manager

Posted 2 days ago
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Job Description
**Industry/Sector:** Not Applicable
**Time Type:** Full time
**Travel Requirements:** Up to 20%
At PwC, our people in tax services focus on providing advice and guidance to clients on tax planning, compliance, and strategy. These individuals help businesses navigate complex tax regulations and optimise their tax positions.
In specialised tax services at PwC, you will focus on providing tax advice and solutions to clients in complex and niche areas of taxation. This includes areas such as accounting methods, fixed-assets and research and development tax credits.
Enhancing your leadership style, you motivate, develop and inspire others to deliver quality. You are responsible for coaching, leveraging team member's unique strengths, and managing performance to deliver on client expectations. With your growing knowledge of how business works, you play an important role in identifying opportunities that contribute to the success of our Firm. You are expected to lead with integrity and authenticity, articulating our purpose and values in a meaningful way. You embrace technology and innovation to enhance your delivery and encourage others to do the same.
Examples of the skills, knowledge, and experiences you need to lead and deliver value at this level include but are not limited to:
+ Analyse and identify the linkages and interactions between the component parts of an entire system.
+ Take ownership of projects, ensuring their successful planning, budgeting, execution, and completion.
+ Partner with team leadership to ensure collective ownership of quality, timelines, and deliverables.
+ Develop skills outside your comfort zone, and encourage others to do the same.
+ Effectively mentor others.
+ Use the review of work as an opportunity to deepen the expertise of team members.
+ Address conflicts or issues, engaging in difficult conversations with clients, team members and other stakeholders, escalating where appropriate.
+ Uphold and reinforce professional and technical standards (e.g. refer to specific PwC tax and audit guidance), the Firm's code of conduct, and independence requirements.
The Opportunity
As part of the Corporate Tax - Specialised Tax Services team you provide exceptional technical knowledge and specialization and industry insights. As a Manager you lead teams and manage client accounts, focusing on strategic planning and mentoring junior staff. You are accountable for project success and maintaining elevated standards. Enhancing your leadership style, you motivate, develop and inspire others to deliver quality. You are responsible for coaching, leveraging team member's unique strengths, and managing performance to deliver on client expectations. With your growing knowledge of how business works, you play an important role in identifying opportunities that contribute to the success of our Firm. You are expected to lead with integrity and authenticity, articulating our purpose and principles in a meaningful way. You embrace technology and innovation to enhance your delivery and encourage others to do the same. This role involves working closely on clients with the latest technologies and platforms in lending, digital banking, payments, crypto and blockchain, insurance and real estate.
Responsibilities
- Lead teams and manage client accounts
- Focus on strategic planning and mentoring junior staff
- Oversee project success and maintain elevated standards
- Motivate, develop, and inspire team members
- Leverage team strengths to meet client expectations
- Identify opportunities that contribute to the firm's success
- Embrace technology and innovation in service delivery
- Foster a culture of integrity and authenticity
What You Must Have
- Bachelor's Degree
- 4 years of experience
- CPA, Member of the Bar or other tax, technology, or finance-specific credentials may qualify for this opportunity
What Sets You Apart
- Knowledge of R&D tax issues
- Skills in analyzing organizations for R&D tax benefits
- Technical skills with research credit regulations
- Experience with R&D databases
- Proficiency in client relationship management
- Proficiency in project workflow and budgeting
- Leadership in coaching and providing feedback
- Automation and digitization proficiency
- Knowledge of pricing strategies
Learn more about how we work: does not intend to hire experienced or entry level job seekers who will need, now or in the future, PwC sponsorship through the H-1B lottery, except as set forth within the following policy: PwC is an equal opportunity employer, all qualified applicants will receive consideration for employment at PwC without regard to race; color; religion; national origin; sex (including pregnancy, sexual orientation, and gender identity); age; disability; genetic information (including family medical history); veteran, marital, or citizenship status; or, any other status protected by law.
For only those qualified applicants that are impacted by the Los Angeles County Fair Chance Ordinance for Employers, the Los Angeles' Fair Chance Initiative for Hiring Ordinance, the San Francisco Fair Chance Ordinance, San Diego County Fair Chance Ordinance, and the California Fair Chance Act, where applicable, arrest or conviction records will be considered for Employment in accordance with these laws. At PwC, we recognize that conviction records may have a direct, adverse, and negative relationship to responsibilities such as accessing sensitive company or customer information, handling proprietary assets, or collaborating closely with team members. We evaluate these factors thoughtfully to establish a secure and trusted workplace for all.
Applications will be accepted until the position is filled or the posting is removed, unless otherwise set forth on the following webpage. Please visit this link for information about anticipated application deadlines: salary range for this position is: $99,000 - $266,000, plus individuals may be eligible for an annual discretionary bonus. For roles that are based in Maryland, this is the listed salary range for this position. Actual compensation within the range will be dependent upon the individual's skills, experience, qualifications and location, and applicable employment laws. PwC offers a wide range of benefits, including medical, dental, vision, 401k, holiday pay, vacation, personal and family sick leave, and more. To view our benefits at a glance, please visit the following link:
Specialized Tax Services - Research & Development Tax Senior Manager

Posted 2 days ago
Job Viewed
Job Description
**Industry/Sector:** Not Applicable
**Time Type:** Full time
**Travel Requirements:** Up to 20%
At PwC, our people in tax services focus on providing advice and guidance to clients on tax planning, compliance, and strategy. These individuals help businesses navigate complex tax regulations and optimise their tax positions.
In specialised tax services at PwC, you will focus on providing tax advice and solutions to clients in complex and niche areas of taxation. This includes areas such as accounting methods, fixed-assets and research and development tax credits.
Growing as a strategic advisor, you leverage your influence, expertise, and network to deliver quality results. You motivate and coach others, coming together to solve complex problems. As you increase in autonomy, you apply sound judgment, recognising when to take action and when to escalate. You are expected to solve through complexity, ask thoughtful questions, and clearly communicate how things fit together. Your ability to develop and sustain high performing, diverse, and inclusive teams, and your commitment to excellence, contributes to the success of our Firm.
Examples of the skills, knowledge, and experiences you need to lead and deliver value at this level include but are not limited to:
+ Craft and convey clear, impactful and engaging messages that tell a holistic story.
+ Apply systems thinking to identify underlying problems and/or opportunities.
+ Validate outcomes with clients, share alternative perspectives, and act on client feedback.
+ Direct the team through complexity, demonstrating composure through ambiguous, challenging and uncertain situations.
+ Deepen and evolve your expertise with a focus on staying relevant.
+ Initiate open and honest coaching conversations at all levels.
+ Make difficult decisions and take action to resolve issues hindering team effectiveness.
+ Model and reinforce professional and technical standards (e.g. refer to specific PwC tax and audit guidance), the Firm's code of conduct, and independence requirements.
The Opportunity
As part of the Corporate Tax - Specialized Tax Services team you are expected to lead the way as technology-enabled tax advisors who provide benefits through digitization, automation, and increased efficiencies. As a Senior Manager you are expected to lead large projects, innovate processes, and maintain operational excellence while interacting with clients at a senior level to drive project success. You are expected to leverage your specialized knowledge and technical acumen of industry-leading business trends, the firm's client service offerings, and professional industry networks to deliver quality results to clients and provide strategic input into the firm's business strategies.
Responsibilities
- Oversee large-scale projects and confirm timely delivery
- Create and implement innovative processes to boost efficiency
- Maintain exceptional operational standards
- Interact with clients at a senior level to drive project success
- Establish trust with multi-level teams and stakeholders through clear communication
- Encourage and mentor teams to tackle complex issues
- Apply specialized technical knowledge and industry insights
- Deliver results by leveraging the firm's broad service offerings
What You Must Have
- Bachelor's Degree
- 5 years of experience
- CPA, Member of the Bar or other tax, technology, or finance-specific credentials may qualify for this opportunity
What Sets You Apart
- In-depth knowledge of R&D tax issues
- Interviewing clients to recognize tax liability savings
- Technical skills with research credit regulations
- Building and utilizing networks of client relationships
- Managing resource requirements and project workflow
- Supervising teams to create an atmosphere of trust
- Developing new relationships and selling new services
- Familiarity with a CRM system
- Leading as a business advisor
Learn more about how we work: does not intend to hire experienced or entry level job seekers who will need, now or in the future, PwC sponsorship through the H-1B lottery, except as set forth within the following policy: PwC is an equal opportunity employer, all qualified applicants will receive consideration for employment at PwC without regard to race; color; religion; national origin; sex (including pregnancy, sexual orientation, and gender identity); age; disability; genetic information (including family medical history); veteran, marital, or citizenship status; or, any other status protected by law.
For only those qualified applicants that are impacted by the Los Angeles County Fair Chance Ordinance for Employers, the Los Angeles' Fair Chance Initiative for Hiring Ordinance, the San Francisco Fair Chance Ordinance, San Diego County Fair Chance Ordinance, and the California Fair Chance Act, where applicable, arrest or conviction records will be considered for Employment in accordance with these laws. At PwC, we recognize that conviction records may have a direct, adverse, and negative relationship to responsibilities such as accessing sensitive company or customer information, handling proprietary assets, or collaborating closely with team members. We evaluate these factors thoughtfully to establish a secure and trusted workplace for all.
Applications will be accepted until the position is filled or the posting is removed, unless otherwise set forth on the following webpage. Please visit this link for information about anticipated application deadlines: salary range for this position is: $124,000 - $335,000, plus individuals may be eligible for an annual discretionary bonus. For roles that are based in Maryland, this is the listed salary range for this position. Actual compensation within the range will be dependent upon the individual's skills, experience, qualifications and location, and applicable employment laws. PwC offers a wide range of benefits, including medical, dental, vision, 401k, holiday pay, vacation, personal and family sick leave, and more. To view our benefits at a glance, please visit the following link:
Staff Engineer Research and Development (Onsite)

Posted 2 days ago
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Job Description
When you join the team at Cordis, you become part of an inspiring mission to save lives, impacting millions of people and broadening access to life-saving cardiovascular and endovascular technology. As a global leader for over 60 years, we are dedicated to being the heart of innovation to transform cardiovascular care.
At Cordis, we're teammates, not just employees. We embrace an empowered and one-team culture where teammates are inspired to unleash their full potential. With diverse teams on a global scale, we believe the richness of our experiences and backgrounds enhances the careers of our teammates, the service to our customers, and ultimately, the lives of our patients.
If you love a challenge and are ready to have a direct, transformative and positive impact on the lives of millions, then Cordis is just the place for you. We are the people behind the people who keep saving lives.
**Responsibilities**
The current position requires design and development expertise in vascular closure devices with relevant clinical application experience, and a good understanding of cardiovascular catheter technologies and procedures.
+ Applies comprehensive medical device engineering knowledge and a thorough understanding of concepts, principles, and technical capabilities to achieve design realization of medical devices.
+ Plans and develops engineering projects concerned with unique or controversial problems which have an important effect on major organization programs. This involves exploration of subject area, definition of scope and selection of problems for investigation and development of novel concepts and approaches.
+ Identifies internal and external customer needs. Translates needs and requirements into tests cases for design verification and validation.
+ Accountable for design reviews as applicable ensuring that verification and validation tests are documented, evaluated against design input, and executed properly.
+ Develops and monitors work schedule to ensure on time completion of testing activities assigned.
+ Supervision received is essentially administrative with assignments given in terms of broad general objectives and limits.
+ Acts as individual technical expert, conceives or is assigned, plans, and conducts research in problem areas of considerable scope and complexity
+ Anticipates, plans, and implements new innovative test methods; provides critical design input to specific situations; has a broader knowledge of the testing environment; gains cross functional alignment across the organization.
+ Able to summarize results of design work and research studies concisely. Participates in the regulatory submission process as a subject matter expert. Supports regulatory by providing technical justifications for submissions, reviewing regulatory filings, and answering technical questions during planned meetings.
+ Responsible for ensuring personal and company compliance with all Federal, State, local and company regulations, policies and procedures for Health, Safety and Environmental.
**Qualifications**
+ Bachelor's degree in Mechanical Engineering or Biomedical Engineering is required.
+ MS Degree in Engineering discipline preferred.
+ A minimum of 8 years related work experience and design experience in vascular closure device preferred.
+ Proven ability in the design and development (including process engineering) of cardiovascular catheter technologies including design experience in vascular closure devices.
+ Must possess clearly recognizable outstanding technical qualifications and leadership.
+ Proven proficiency in Computer Aided Design or SolidWorks preferred.
+ English communication skills, written and oral.
**Preferred Qualifications**
Pay / Compensation
The expected pre-tax pay rate for this position is $121,800 - $174,000 per year
Actual pay may fluctuate outside of the listed range depending on skills, education, experience, job-related knowledge and location.
US work authorization is a precondition of employment. The company will not consider candidates who require sponsorship for a work-authorized visa.
Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities
Cordis is proud to be an equal opportunity employer and is committed to providing equal opportunity for all teammates and applicants. At Cordis, our teammates all bring different strengths, experiences, and backgrounds, who share a passion for improving people's lives. Diversity not only includes race and gender identity, but also age, disability status, veteran status, sexual orientation, religion, and many other parts of one's identity. All our teammate's points of view are key to our success, and we believe inclusion is everyone's responsibility. Together, we strive to create and maintain working and learning environments that are inclusive, equitable and welcoming.
**JOIN OUR TALENT COMMUNITY**
Joining our Talent Community is a great way to receive company news and updates, as well notifications on career opportunities and events that interest you! Please tell us more about yourself so we can align you with future opportunities that match your background, skills and interests.
**Job Locations** _US-CA-Santa Clara_
**ID** _ _
**Category** _Research and Development (R&D)_
**Position Type** _Regular Full-Time_
CORDIS is proud to be an equal opportunity employer, values diversity in all its forms is and committed to fostering an inclusive work environment. We are committed to advancing our culture of belonging, where all teammates feel seen, heard, and appreciated and encouraged to be their authentic selves. Our team is invested in attracting, retaining and growing top talent. Our Teammates are the core of our innovation and success. Cordis is an inclusive, engaging place to work and grow a career. CORDIS is committed to offering reasonable accommodations, upon request, to job applicants with disabilities. If you need assistance or an accommodation due to a disability, please contact
Research and Development (R&D) Service Engineer

Posted 3 days ago
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Job Description
As an **Research and Development (R&D) Service Engineer** in Orchestration Platforms, you will contribute directly to the design, deployment, and support of next-generation orchestration systems that power large-scale AI workloads. This area spans the full lifecycle, from an initial requirement to run a workload, to the ongoing maintenance, monitoring, and optimization of the orchestration platform itself. You will help provide unified architecture and a curated set of tools, so researchers always have the best possible platform for their specific computational needs.
Microsoft's mission is to empower every person and every organization on the planet to achieve more. As employees we come together with a growth mindset, innovate to empower others, and collaborate to realize our shared goals. Each day we build on our values of respect, integrity, and accountability to create a culture of inclusion where everyone can thrive at work and beyond.
In alignment with our Microsoft values, we are committed to cultivating an inclusive work environment for all employees to positively impact our culture every day.
**Responsibilities**
+ You will develop andoperateorchestration platforms using Kubernetes and Volcano, ensuring seamless job submission, scheduling, and monitoring for large-scale AI workloads.
+ Contribute to service design by recommendingoptimalconfigurations with awareness of cost, security, resiliency, and scalability.
+ Refine cluster and scheduler configurations to improve availability, reliability, observability, and performance.
+ Collaborate closely with Edge, Networking, Reliability, and Automation teams to integrate orchestration with hybrid and distributed systems.
+ Take part in design reviews, share learnings, and help define measurable health and performance metrics for orchestration services.
+ Stayinformedof evolving orchestration technologies, adoptingnew solutionsand proactively seeking opportunities to improve.
+ Embody our culture ( and values ( .
**Qualifications**
**Required Qualifications**
+ Bachelor's Degree in Computer Science, Information Technology, Electrical Engineering, Data Science, Cybersecurity, or related field AND 2+ years technical experience in software engineering, network engineering, service engineering, systems engineering, or industrial controls
+ OR equivalent experience.
+ 2+ years of experience managing and supporting Graphics Processing Unit (GPU) clusters (e.g., NVIDIA, AMD) with an emphasis on uptime, availability, and proactive maintenance.
+ 1+ year(s) of experience with Kubernetes and Volcano or other advanced workload scheduling frameworks for large-scale Artificial Intelligence/Machine Learning (AI/ML) jobs.
+ 1+ year(s) of experience troubleshooting across hardware, software, networking, and system logs, with a proven ability to resolve complex issues.
**Preferred Qualifications**
+ Bachelor's Degree in Computer Science, Information Technology, Electrical Engineering, Data Science, Cybersecurity, or related field AND 5+ years technical experience working with large-scale cloud, GPU or distributed systems
+ OR Master's Degree in Computer Science, Information Technology, Electrical Engineering, Data Science, Cybersecurity, or related field AND 2+ years technical experience in software engineering, network engineering, service engineering, systems engineering, or industrial controls
+ OR equivalent experience.
+ Proficiency with observability and monitoring platforms (e.g., Prometheus, Grafana) for tracking system health, performance, and service-level indicators.
+ Familiarity with CUDA programming, GPU optimization, or large-scale model training environments.
+ Experience designing or optimizing orchestration platforms for hybrid or distributed systems spanning edge and cloud.
+ Demonstrated ability to improve cost efficiency, reliability, and scalability of services through infrastructure or platform design.
+ Prior experience in log analysis, automation, and proactive issue detection to minimize downtime and maximize service health.
+ Ability to collaborate across distributed global teams, communicate effectively, and meet uptime and service-level objectives.
Service Engineering IC3 - The typical base pay range for this role across the U.S. is USD $100,600 - $99,000 per year. There is a different range applicable to specific work locations, within the San Francisco Bay area and New York City metropolitan area, and the base pay range for this role in those locations is USD 131,400 - 215,400 per year.
Certain roles may be eligible for benefits and other compensation. Find additional benefits and pay information here: will accept applications for the role until October 12, 2025.
#Research
#MSRR
Microsoft is an equal opportunity employer. Consistent with applicable law, all qualified applicants will receive consideration for employment without regard to age, ancestry, citizenship, color, family or medical care leave, gender identity or expression, genetic information, immigration status, marital status, medical condition, national origin, physical or mental disability, political affiliation, protected veteran or military status, race, ethnicity, religion, sex (including pregnancy), sexual orientation, or any other characteristic protected by applicable local laws, regulations and ordinances. If you need assistance and/or a reasonable accommodation due to a disability during the application process, read more about requesting accommodations ( .
Sr. Technical Leader, Technology & Platform, Research & Early Development

Posted 2 days ago
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Job Description
**The Position**
At Roche, we are working to make next-generation sequencing simple and accessible enough for routine use. By accelerating clinical research, streamlining workflows, and expanding assay menus, we are broadening access to genomic data and lowering barriers to adoption. From robust sample isolation and preparation tools to novel sequencing technology and advanced bioinformatics, we are developing differentiated, highly integrated end-to-end solutions for next-generation sequencing, resulting in a sample in, result out workflow.
Our Systems Technology Group, a part of Roche Sequencing Solutions, is seeking an accomplished technical leader and visionary to drive next-generation instrument research and early development projects. This is a rare opportunity for a hands-on, multi-disciplinary expert to help architect these next-generation systems and lead the technical teams responsible for designing, building and testing them. As a technical project lead, you will be responsible for synthesizing user needs and advanced chemistry into a cohesive system and for orchestrating the complex interplay between hardware, software, consumables, and biology to deliver functional, high-performance prototypes. This is a role for an expert who thrives on bridging the gap between strategy and implementation, serving as both a key strategic partner and the hands-on technical leader driving execution during the critical research and early development phases.
**The Opportunity**
**Technical Project Leadership & Execution**
+ You will serve as the technical project lead for next-generation instruments, driving projects from concept through functional prototypes, by leading design, building, testing, and troubleshooting activities.
+ You will translate user needs into technical blueprints, decompose system-level requirements into subsystem specifications, and guide data-driven decisions through trade-off studies and technology down-selection.
+ You will direct the end-to-end experimental lifecycle for system characterization and verification, including experimental design, planning, execution, troubleshooting, data analysis, and review for all materials, components, breadboards, and prototypes.
+ You will drive innovation and influence the R&D technology roadmap by rolling up your sleeves to create and test novel concepts, generate intellectual property, and champion new technologies that define the future of our platforms.
**Team & Resource Management:**
+ You will be a key leader in recruiting, mentoring, and developing a world-class, multi-disciplinary R&D team, fostering a culture of strong work ethics, systems-level thinking, engineering and data-driven rigor, and rapid learning cycles.
+ You will act as a hands-on technical leader, capable of executing the work as an individual contributor while mentoring and cultivating the next generation of technical leaders within the organization.
+ You will coordinate the activities of a multi-disciplinary team while managing technical scope, risk, and resources to drive progress against ambitious project milestones.
+ You will identify resource needs and effectively pitch those needs to senior leadership to ensure project success.
+ You will identify, evaluate, and manage relationships with critical technology partners, vendors, and suppliers for key subsystems and components.
**Hands-on Problem Solving & System Characterization:**
+ You will personally lead and contribute to the most critical troubleshooting efforts, directing root cause analysis at the complex interface of hardware, software, consumables, and sequencing chemistry.
+ You will partner with hardware, software, reagent and assay research and development leads to guide the technical strategy for early-stage system verification and integration, defining robust test plans and using data-driven analysis to ensure prototypes meet or exceed all target specifications.
+ You will oversee the research and early development of critical system-level processes and workflows, such as key fluidic protocols, to ensure robust and reliable instrument performance.
+ You will own key system-level documentation, including architectural diagrams, interface control documents, technical risk assessments, and verification plans, ensuring they are living documents that reflect the latest experimental findings.
**A cover letter is required for this application.**
Please outline your relevant experience and explain why you are interested in this role and Roche.
**Who You Are:**
**(Required)**
_Core Technical Experience & Expertise_
+ You have a Ph.D. in Bioengineering, Biomedical Engineering or a closely related discipline with at least 10 years of relevant industry experience; OR a Master's degree in Bioengineering, Biomedical Engineering or a closely related discipline with at least 12 years of relevant industry experience; OR a Bachelor's degree in Bioengineering, Biomedical Engineering or a closely related discipline with at least 14 years of relevant industry experience.
+ You have a demonstrated track record of serving as a technical lead or principal engineer for at least one full product development cycle of a complex life science instrument, from concept through to commercialization.
+ You have demonstrated success leading system-level testing of instruments with complex hardware, software, consumables, reagents, assays, and workflows in a sequencing, life sciences, or diagnostics R&D environment.
+ You possess deep, hands-on expertise in at least one core engineering discipline with broad, system-level knowledge across others, demonstrated by your experience designing, building, and troubleshooting complex instrumentation involving fluidics, thermal control, and advanced sensing or detection technologies.
+ You possess a strong foundational knowledge of the scientific principles underlying next-generation sequencing, including molecular biology, biochemistry, and surface chemistry, enabling you to facilitate effective collaborations between engineering, assay and workflow development teams.
_Systems Engineering & Project Execution_
+ You have proven expertise in applying a systematic, data-driven approach (including DOE and statistical analysis using JMP, R, or Python) to troubleshoot complex issues at the interface of biology, chemistry, and engineering.
+ You have proven experience translating vision and high-level requirements into detailed system and subsystem specifications, and the ability to think strategically, connecting project-level decisions to long-term business and technology goals.
+ You have excellent project management and organizational skills, with proven experience planning, prioritizing, and allocating resources to successfully manage multiple technical projects.
+ You have experience leading technical risk management activities and developing robust mitigation strategies.
_Leadership & Interpersonal Skills_
+ You have demonstrated strong interpersonal and communication skills with the ability to communicate complex technical knowledge in a clear and understandable manner to both technical and non-technical stakeholders.
+ You have successfully demonstrated the ability to recruit, build, and lead high-performing, multi-disciplinary engineering teams, serving as both a manager and a technical mentor.
+ You are an action-oriented and decisive problem-solver, thriving in a fast-paced environment where you work with a sense of urgency, optimism, and deep scientific curiosity.
**Preferred:**
+ You have direct experience with the design and development of next-generation sequencing instrumentation.
+ You have hands-on experience with detailed mechanical design for complex instrumentation, including proficiency with SolidWorks.
+ You have direct experience with advanced microfluidic systems, from design and fabrication to system integration and control.
+ You have demonstrated the ability to solve unique or unprecedented issues that span hardware, software, chemistry, and consumables.
+ You have experience developing products in a regulated environment using rigorous methodologies such as Design for Six Sigma (DFSS) and statistical process control for system characterization and optimization.
+ You have a strong record of innovation, demonstrated by a portfolio of patents and/or publications in relevant fields.
+ You have experience managing external development partners, vendors, and contract manufacturers.
+ You possess a deep scientific curiosity and an innate desire to learn, be challenged, and challenge the status quo.
The expected salary range for this position based on the primary location of Santa Clara, CA is $145,000 - $318,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.
This position also qualifies for the benefits detailed at the link provided below.
Benefits ( we are**
A healthier future drives us to innovate. Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.
Let's build a healthier future, together.
Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants ( .
Principal Manager, Internal Communications, Genentech Research & Early Development (gRED)

Posted 2 days ago
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Job Description
A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech.
As Principal Manager, Internal Communications within Genentech Research and Early Development (gRED), you will serve as both a strategic partner and hands-on communications lead, supporting two core functions: Development Science (DevSci) & Translational Medicine (TM). This is a dual-facing role that requires balancing the distinct needs, cultures, and leadership styles of two critical functions while also connecting their stories to gRED's broader vision and to Roche and Genentech enterprise priorities.
You will partner closely with the leadership teams of DevSci and TM to shape and co-create communication strategies that drive organizational clarity, scientific momentum, and employee engagement. At the same time, you will roll up your sleeves to deliver content, manage channels, and orchestrate events that bring those strategies to life.
This is a rare opportunity to work at the intersection of two scientific organizations that together accelerate the path from research to medicine. You will have a seat at the table with senior leaders, helping to craft the narrative for how DevSci and TM contribute to gRED's mission to revolutionize drug discovery and development.
This position reports to the Senior Director, Head of Internal Communications for gRED.
**The Opportunity**
+ Serve as the primary communications business partner to the leadership teams of both Development Science and Translational Medicine.
+ Shape and execute tailored communications strategies and tactics that reflect the unique cultures and scientific priorities of each function while highlighting their shared contributions to gRED.
+ Provide strategic counsel to senior leaders and act as a trusted advisor on how communications can drive engagement, alignment, and impact.
+ Lead the development and execution of communications plans, including leadership messages, internal articles, newsletters, employee town halls, and digital/multimedia storytelling.
+ Partner across gRED and with colleagues at Genentech and Roche to ensure alignment of messaging, strategy, and timing.
+ Set goals and measure the effectiveness of communications through metrics and employee feedback.
+ Actively cultivate a culture of experimentation, agility, and creativity, applying best practices to deliver innovative, high-impact communications.
**Who you are**
+ BS/BA required
+ 8-10 years of experience in a communications role within a large, matrixed organization
+ Biotech or pharma experience, ideally in research, early development, translational medicine, or development science
+ Proven track record in both strategic communications planning and hands-on content creation and channel management
+ Extensive experience developing messaging and communication strategies that engage employees and support business goals
+ Demonstrated ability to engage directly with senior management, with minimal oversight
+ Strong understanding of executive communications, employee engagement, and event management
**Preferred qualifications**
+ Science background strongly preferred
+ Experience in change management communications is a plus
+ Experience in both internal and external communications a plus
+ Consulting experience a plus
Relocation benefits are not available for this position.
The expected salary range for this position based on the primary location of California is $167,300 - $317,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits ( is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants ( .
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Principal Engineer II, Fluidic Systems Integration, Research & Early Development

Posted 2 days ago
Job Viewed
Job Description
**The Position**
A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Roche.
At Roche, we are working to make next-generation sequencing simple and accessible enough for routine use. By accelerating clinical research, streamlining workflows, and expanding assay menus, we are broadening access to genomic data and lowering barriers to adoption. From robust sample isolation and preparation tools to novel sequencing technology and advanced bioinformatics, we are developing differentiated, highly integrated end-to-end solutions for next-generation sequencing, resulting in a sample in, result out workflow.
Our Systems Technology Group, a part of Roche Sequencing Solutions, is focused on creating and advancing technologies to significantly enhance DNA sequencing workflows. We are seeking a Principal System Integration Engineer II to serve as a critical bridge between fundamental scientific discovery and tangible engineering execution during the earliest stages of research and development.
This is a pivotal, hands-on role for a multidisciplinary expert who is passionate about pioneering new technologies by mastering the complex intersection of chemistry, molecular biology, and biochemistry with hardware, surfaces, and materials. The ideal candidate lives at the nexus of these domains, capable of translating the first principles of biology into novel fluidic and mechatronic systems. **This role is designed to break the traditional R&D model where scientific and engineering teams operate in sequence.** Instead of being a liaison _between_ teams, this individual will be the embodiment of both disciplines, personally driving technology from a theoretical concept to a functional, proof-of-concept breadboard. **You will be the inventive force responsible for answering the most fundamental question in our R&D cycle: "Is this new technology physically possible?"** You will bring instruments from initial concept to demonstrated feasibility, laying the technical foundation for the next generation of sequencing platforms.
**Role & Responsibilities:**
+ Concept & Feasibility: You will invent, prototype, and characterize novel devices, subsystems, and workflows for next-generation sequencing applications, with a primary focus on establishing fundamental feasibility and de-risking new technological approaches.
+ Workflow Translation: You will lead the effort to translate complex, multi-step biochemical and molecular biology protocols from the benchtop onto early-stage instruments, breadboards, and custom test fixtures with novel fluidic and microfluidic systems.
+ Hands-on Development & Testing: You will personally design, build, and commission custom test fixtures, breadboards, and automation scripts (e.g., Python, LabView) required for early-stage system characterization, proof-of-concept validation, and feasibility studies.
+ Hypothesis-Driven Experimentation: You will design and execute rigorous, hypothesis-driven experiments to characterize system performance, pushing the boundaries of new technologies and identifying critical failure modes at the interface of biology, chemistry, and hardware.
+ First-Principles Troubleshooting: You will lead early-stage, deep-dive troubleshooting efforts for complex performance issues on novel systems, seamlessly connecting systemic failures back to first-principles root causes-whether molecular, chemical, material, or physical.
+ Data Analysis & Communication: You will analyze complex, multi-modal data sets, author detailed technical reports and feasibility studies, generate intellectual property, and present findings to technical teams and R&D leadership to inform technology roadmap decisions.
+ Cross-Functional Collaboration: You will serve as a key technical partner to assay development scientists and hardware design engineers, providing critical, data-driven feedback to guide the co-development of reagents, consumables, and instrument hardware, ensuring that biological requirements and engineering constraints are harmonized from day one.
**A cover letter is required for this application.**
Please outline your relevant experience and explain why you are interested in this role and Roche.
**Who You Are:**
**(Required)**
+ Education & Experience: You have a PhD in Bioengineering, Biomedical Engineering, Chemical Engineering, Biophysics, Molecular Biology, or a closely related discipline with 7+ years of relevant industry experience; OR a Master's degree in Bioengineering, Biomedical Engineering, Chemical Engineering, Biophysics, Molecular Biology or closely related discipline with 8+ years of relevant industry experience; OR a Bachelor's degree in Bioengineering, Biomedical Engineering, Chemical Engineering, Biophysics, Molecular Biology or closely related discipline with 10+ years of relevant industry experience.
+ Core Technical Expertise: You have demonstrated, hands-on success translating complex biological or chemical workflows (e.g., library prep, enzymatic assays, immunoassays) onto prototype instruments, breadboards, or integrated microfluidic devices in a life sciences or diagnostics R&D environment.
+ Interdisciplinary Knowledge: You possess a deep, intuitive understanding of the fundamental principles of molecular biology, biochemistry, and enzymology, and a proven ability to apply this knowledge to solve complex hardware, fluidics, and materials science challenges.
+ Fluidics & Hardware Acumen: You have proficiency in designing, building, and troubleshooting complex fluidic and microfluidic systems. You think in terms of flow rates, pressures, surface tensions, and material compatibility as fluently as you do about DNA concentrations and enzyme kinetics.
+ Problem-Solving & Mindset: You have a demonstrated ability to troubleshoot from a first-principles perspective, identifying and resolving ambiguous issues that span molecular biology, chemistry, hardware, consumables, and software. You exhibit a high degree of ingenuity, resourcefulness, and scientific curiosity to invent new technology and develop cutting-edge concepts in a fast-paced, ambiguous R&D environment.
+ Communication: You have demonstrated strong interpersonal and communication skills with the ability to communicate complex technical knowledge in a clear and understandable manner to a multidisciplinary team.
**Preferred:**
+ You have hands-on experience defining workflows and then translating them onto instrumentation by writing custom scripts via Python, MATLAB, LabView or custom fluidic simulation software).
+ You have hands-on experience with CAD for designing custom parts, fixtures, and consumables (e.g., SolidWorks).
+ You have experience with advanced microfabrication techniques.
+ You have a strong record of innovation, demonstrated by a portfolio of patents and/or publications in relevant fields.
+ You have direct experience using Design of Experiments (DOE) and statistical analysis tools (e.g., JMP, R).
This is an on-site position based in Santa Clara, CA.
Relocation benefits are not being offered for this role.
The expected salary range for this position based on the primary location of Santa Clara, CA is $127,000 - $236,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.
This position also qualifies for the benefits detailed at the link provided below.
Benefits ( we are**
A healthier future drives us to innovate. Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.
Let's build a healthier future, together.
Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants ( .
Research and Development Scientist and Engineer (1 Year Fixed-Term)
Posted 1 day ago
Job Viewed
Job Description
Stanford University, the Personalized Integrative Medicine Laboratory in the Radiology Department ( ) and the Urologic Cancer Innovation Laboratory ( ) is seeking a creative, highly motivated, Research and Development Scientist and Engineer 1 with an interest in developing platforms that integrate and deploy multimodal machine learning methods in clinical applications.
The project is focused on developing a software platform to deploy our existing ultrasound-MRI models for prostate cancer detection in clinical practices. The position requires managing complex multi-modal data sets including clinical assessments, laboratory results, radiological images and pathological findings, to develop a user-friendly software that will encompass existing approaches and allows for easy integration of new models. The successful candidate will join the Department of Radiology at Stanford University and will work with a multi-disciplinary team of clinicians, statisticians, computer scientists, and trainees. This position is available immediately and has a 1-year duration, with possibility of extension based on funding availability and mutual agreement.
Duties include*:
- Design and develop specialized software and tools; coordinate detailed phases of work related to responsibility for part of a major project.
- Develop technical and methodological solutions to complex engineering/scientific problems requiring independent analytical thinking and advanced knowledge.
- Develop creative new or improved equipment, materials, technologies, processes, methods, or software important to the advancement of the field.
- Contribute technical expertise, and perform basic research and development in support of programs/projects; act as advisor/consultant in area of specialty.
- Optional: Contribute to portions of published articles or presentations; prepare and write reports; draft and prepare scientific papers.
- Provide technical directions to other research staff, engineering associates, technicians, and/or students, as needed.
* - Other duties may also be assigned.
DESIRED QUALIFICATIONS:
- Candidates should have prior experience in software and platform development and C++/python/docker/UIX programming, and be familiar with toolkits, e.g., ITK, opencv, sklearn.
- Candidate should have prior experience with Designing User Interfaces, including image visualization and connect platforms with docker containers.
- Candidates with experience in radiomics, segmentation, image registration are strongly encouraged to apply.
- Candidates should have demonstrated ability to work independently, attention to details, be dedicated and self-motivated.
- Collaborative team spirit, strong communication skills, positive attitude and adherence to highest ethical principles are necessary to be considered.
- The candidate should have knowledge and experience in machine learning and deep learning, visualization, platform implementation.
- The preferred candidate would also have experience with medical image processing, and traditional signal processing techniques.
EDUCATION & EXPERIENCE (REQUIRED):
Bachelor's degree and three years of relevant experience, or combination of education and relevant experience. Preferred candidates will have an M.S. with relevant experience or Ph.D. in Biomedical Engineering, Electrical Engineering, Biomedical Informatics, Computer Science or related fields.
KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
- Thorough knowledge of the principles of engineering and related natural sciences.
- Demonstrated project management experience.
PHYSICAL REQUIREMENTS*:
- Frequently grasp lightly/fine manipulation, perform desk-based computer tasks, lift/carry/push/pull objects that weigh up to 10 pounds.
- Occasionally stand/walk, sit, twist/bend/stoop/squat, grasp forcefully.
- Rarely kneel/crawl, climb (ladders, scaffolds, or other), reach/work above shoulders, use a telephone, writing by hand, sort/file paperwork or parts, operate foot and/or hand controls, lift/carry/push/pull objects that weigh > 40 pounds.
* - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.
WORKING CONDITIONS:
- May be exposed to high voltage electricity, radiation or electromagnetic fields, lasers, noise > 80dB TWA, Allergens/Biohazards/Chemicals /Asbestos, confined spaces, working at heights of 10 feet, temperature extremes, heavy metals, unusual work hours or routine overtime and/or inclement weather.
- May require travel.
WORK STANDARDS:
- Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
- Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.
- Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, .
The expected pay range for this position is $127,211 to $154,222 per annum.
Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs.
At Stanford University, base pay represents only one aspect of the comprehensive rewards package. The Cardinal at Work website ( ) provides detailed information on Stanford’s extensive range of benefits and rewards offered to employees. Specifics about the rewards package for this position may be discussed during the hiring process.
Consistent with its obligations under the law, the University will provide reasonable accommodations to applicants and employees with disabilities. Applicants requiring a reasonable accommodation for any part of the application or hiring process should contact Stanford University Human Resources by submitting a contact form .
Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
The job duties listed are typical examples of work performed by positions in this job classification and are not designed to contain or be interpreted as a comprehensive inventory of all duties, tasks, and responsibilities. Specific duties and responsibilities may vary depending on department or program needs without changing the general nature and scope of the job or level of responsibility. Employees may also perform other duties as assigned.
Research and Development Scientist and Engineer (1 Year Fixed-Term)

Posted today
Job Viewed
Job Description
**School of Medicine, Stanford, California, United States**
**New**
Research
Post Date 3 days ago
Requisition #
Stanford University, the Personalized Integrative Medicine Laboratory in the Radiology Department ( and the Urologic Cancer Innovation Laboratory ( is seeking a creative, highly motivated, Research and Development Scientist and Engineer 1 with an interest in developing platforms that integrate and deploy multimodal machine learning methods in clinical applications.
The project is focused on developing a software platform to deploy our existing ultrasound-MRI models for prostate cancer detection in clinical practices. The position requires managing complex multi-modal data sets including clinical assessments, laboratory results, radiological images and pathological findings, to develop a user-friendly software that will encompass existing approaches and allows for easy integration of new models. The successful candidate will join the Department of Radiology at Stanford University and will work with a multi-disciplinary team of clinicians, statisticians, computer scientists, and trainees. This position is available immediately and has a 1-year duration, with possibility of extension based on funding availability and mutual agreement.
**Duties include*:**
+ Design and develop specialized software and tools; coordinate detailed phases of work related to responsibility for part of a major project.
+ Develop technical and methodological solutions to complex engineering/scientific problems requiring independent analytical thinking and advanced knowledge.
+ Develop creative new or improved equipment, materials, technologies, processes, methods, or software important to the advancement of the field.
+ Contribute technical expertise, and perform basic research and development in support of programs/projects; act as advisor/consultant in area of specialty.
+ Optional: Contribute to portions of published articles or presentations; prepare and write reports; draft and prepare scientific papers.
+ Provide technical directions to other research staff, engineering associates, technicians, and/or students, as needed.
_* - Other duties may also be assigned._
**DESIRED QUALIFICATIONS:**
+ Candidates should have prior experience in software and platform development and C++/python/docker/UIX programming, and be familiar with toolkits, e.g., ITK, opencv, sklearn.
+ Candidate should have prior experience with Designing User Interfaces, including image visualization and connect platforms with docker containers.
+ Candidates with experience in radiomics, segmentation, image registration are strongly encouraged to apply.
+ Candidates should have demonstrated ability to work independently, attention to details, be dedicated and self-motivated.
+ Collaborative team spirit, strong communication skills, positive attitude and adherence to highest ethical principles are necessary to be considered.
+ The candidate should have knowledge and experience in machine learning and deep learning, visualization, platform implementation.
+ The preferred candidate would also have experience with medical image processing, and traditional signal processing techniques.
**EDUCATION & EXPERIENCE (REQUIRED):**
Bachelor's degree and three years of relevant experience, or combination of education and relevant experience. Preferred candidates will have an M.S. with relevant experience or Ph.D. in Biomedical Engineering, Electrical Engineering, Biomedical Informatics, Computer Science or related fields.
**KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):**
+ Thorough knowledge of the principles of engineering and related natural sciences.
+ Demonstrated project management experience.
**PHYSICAL REQUIREMENTS*:**
+ Frequently grasp lightly/fine manipulation, perform desk-based computer tasks, lift/carry/push/pull objects that weigh up to 10 pounds.
+ Occasionally stand/walk, sit, twist/bend/stoop/squat, grasp forcefully.
+ Rarely kneel/crawl, climb (ladders, scaffolds, or other), reach/work above shoulders, use a telephone, writing by hand, sort/file paperwork or parts, operate foot and/or hand controls, lift/carry/push/pull objects that weigh > 40 pounds.
_* - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job._
**WORKING CONDITIONS:**
+ May be exposed to high voltage electricity, radiation or electromagnetic fields, lasers, noise > 80dB TWA, Allergens/Biohazards/Chemicals /Asbestos, confined spaces, working at heights of 10 feet, temperature extremes, heavy metals, unusual work hours or routine overtime and/or inclement weather.
+ May require travel.
**WORK STANDARDS:**
+ Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
+ Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.
+ Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, expected pay range for this position is $127,211 to $154,222 per annum._
_Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs._
_At Stanford University, base pay represents only one aspect of the comprehensive rewards package. The Cardinal at Work website (_ _ _) provides detailed information on Stanford's extensive range of benefits and rewards offered to employees. Specifics about the rewards package for this position may be discussed during the hiring process._
_Consistent with its obligations under the law, the University will provide reasonable accommodations to applicants and employees with disabilities. Applicants requiring a reasonable accommodation for any part of the application or hiring process should contact Stanford University Human Resources by submitting a_ _contact form_ _._
_Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law._
_The job duties listed are typical examples of work performed by positions in this job classification and are not designed to contain or be interpreted as a comprehensive inventory of all duties, tasks, and responsibilities. Specific duties and responsibilities may vary depending on department or program needs without changing the general nature and scope of the job or level of responsibility. Employees may also perform other duties as assigned._
Additional Information
+ **Schedule: Full-time**
+ **Job Code: 4981**
+ **Employee Status: Fixed-Term**
+ **Grade: J**
+ **Requisition ID: **
+ **Work Arrangement : On Site**