30 Amgen jobs in South San Francisco

Our client is searching for a world-class Principal Scientist to lead groundbreaking research initiatives in drug discovery within a fully remote setting. This pivotal role focuses on identifying and validating novel therapeutic targets, designing innovative small molecules, and advancing preclinical candidates through the early stages of development. You will operate at the forefront of pharmaceutical innovation, contributing to the design and execution of complex research strategies that address unmet medical needs. The position requires a deep scientific understanding, exceptional creativity, and the ability to collaborate effectively with a dispersed team of leading researchers. This is an exceptional opportunity for a seasoned scientist to make a significant impact on human health, working entirely from their home office. The position is associated with San Francisco, California, US , but is executed remotely.

Responsibilities:

• Lead and execute research programs focused on the discovery of novel therapeutics for (Specify Disease Area, e.g., oncology, neurodegenerative diseases).
  
• Identify, validate, and characterize new drug targets using cutting-edge molecular biology and biochemical techniques.
  
• Design and synthesize diverse chemical libraries, and employ structure-activity relationship (SAR) studies to optimize lead compounds.
  
• Develop and implement high-throughput screening (HTS) assays and cellular assays for target engagement and efficacy.
  
• Collaborate with computational chemists and structural biologists to guide drug design efforts.
  
• Manage external collaborations with academic institutions and CROs.
  
• Analyze and interpret complex biological and chemical data, presenting findings clearly to internal teams and external partners.
  
• Mentor junior scientists and contribute to the strategic direction of the drug discovery pipeline.
  
• Stay current with the latest advancements in medicinal chemistry, pharmacology, and relevant disease biology.
  
• Contribute to the preparation of patent applications and scientific publications.

Qualifications:

• Ph.D. in Pharmacology, Medicinal Chemistry, Biochemistry, Molecular Biology, or a related field.
  
• Minimum of 10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry, with a proven track record of successfully advancing drug candidates.
  
• Extensive experience in small molecule drug discovery, including target identification, lead optimization, and preclinical development.
  
• Deep understanding of assay development, HTS, SAR, and ADME/Tox principles.
  
• Proficiency in biophysical techniques and structural biology is a significant advantage.
  
• Exceptional record of scientific publication and presentation.
  
• Demonstrated leadership capabilities and experience in managing research projects and teams.
  
• Excellent communication, collaboration, and problem-solving skills.
  
• Proficiency in data analysis software and bioinformatics tools.
  
• Must have a dedicated home office setup with reliable high-speed internet to facilitate seamless remote work.

This is a truly unique opportunity to shape the future of medicine. If you are a visionary scientist driven by innovation and impact, we encourage you to apply.

Our client, a cutting-edge Pharmaceutical company, is seeking a highly accomplished Principal Drug Discovery Scientist to join their innovative, fully remote research team. This is a pivotal role for an experienced scientist passionate about identifying and developing novel therapeutics. You will lead critical research initiatives aimed at discovering new drug candidates for unmet medical needs across various disease areas. Responsibilities include designing and executing complex experimental strategies, managing drug discovery projects from target identification through lead optimization, and evaluating the efficacy and safety of potential drug candidates. You will be expected to contribute significantly to the intellectual property of the company through patent filings and scientific publications. The ideal candidate will have a Ph.D. in Pharmacology, Medicinal Chemistry, Biology, or a related life sciences discipline, with a minimum of 10-12 years of progressive experience in drug discovery within the pharmaceutical or biotech industry. Expertise in a specific therapeutic area (e.g., oncology, immunology, neuroscience) and a proven track record of bringing small molecule or biologic drug candidates into preclinical development are highly desirable. Strong leadership skills, the ability to mentor junior scientists, and exceptional project management capabilities are essential. You should be proficient in modern drug discovery techniques, including high-throughput screening, structure-based drug design, ADME/Tox profiling, and in vivo pharmacology. Excellent communication and presentation skills are necessary for collaborating with internal teams and external partners, as well as for presenting findings to senior leadership. This fully remote position offers the flexibility to work from anywhere while contributing to life-changing advancements in medicine. We are looking for a visionary scientist with a deep scientific understanding, a strategic mindset, and a commitment to scientific excellence and innovation. Join our mission to transform patient lives through groundbreaking pharmaceutical research.

Key Responsibilities:

• Lead and manage drug discovery programs from inception to preclinical development.
• Design and execute complex biological and pharmacological experiments.
• Identify and validate novel drug targets for therapeutic intervention.
• Evaluate lead compounds for efficacy, safety, and pharmacokinetic properties.
• Contribute to the design and synthesis of novel drug molecules.
• Oversee the interpretation of experimental data and the progression of projects.
• Mentor and guide junior research staff.
• Prepare scientific manuscripts for publication and patent applications.
• Collaborate effectively with cross-functional teams and external partners.

Qualifications:

• Ph.D. in Pharmacology, Medicinal Chemistry, Biology, or a related field.
• 10+ years of experience in drug discovery in the pharmaceutical or biotechnology industry.
• Demonstrated expertise in a specific therapeutic area (e.g., oncology, infectious diseases).
• Proven track record of successfully advancing drug candidates.
• Strong knowledge of drug discovery processes, methodologies, and technologies.
• Experience with in vitro and in vivo preclinical models.
• Excellent leadership, project management, and communication skills.
• Ability to work independently and effectively in a remote research environment.

Our client, a cutting-edge biopharmaceutical company focused on developing novel therapeutics, is seeking a highly accomplished Principal Scientist to lead critical drug discovery initiatives. This position, based in our San Francisco, California, US R&D hub, offers a hybrid work model. You will be at the forefront of identifying and validating new drug targets, designing and executing complex biological experiments, and contributing to the early-stage development of innovative medicines. Responsibilities include leading a team of scientists, managing research projects from conception to milestone achievement, and interpreting complex experimental data. The ideal candidate will have a Ph.D. in Molecular Biology, Biochemistry, Pharmacology, or a related life sciences discipline, with a strong track record of impactful research in drug discovery. Expertise in at least one therapeutic area (e.g., oncology, immunology, neuroscience) and familiarity with various assay development platforms (e.g., HTS, phenotypic screening, target-based assays) are essential. You should have extensive experience in data analysis, hypothesis generation, and experimental design. Proven leadership capabilities, excellent written and verbal communication skills, and the ability to collaborate effectively with cross-functional teams are paramount. A minimum of 10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry is required. This hybrid role allows for a balance between vital in-lab work at our San Francisco, California, US facility and the flexibility of remote work for data analysis and reporting. Join us in our mission to revolutionize patient care through groundbreaking scientific innovation.

**The Position**
A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Roche.
Advances in AI, data, and computational sciences are transforming drug discovery and development. Roche's Research and Early Development organisations at Genentech (gRED) and Pharma (pRED) have demonstrated how these technologies accelerate R&D, leveraging data and novel computational models to drive impact. Seamless data sharing and access to models across gRED and pRED are essential to maximising these opportunities. The new Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness the transformative power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative medicines for patients worldwide.
**The Opportunity**
At Roche's AI for Drug Discovery (AIDD) group (Prescient Design), we are revolutionizing drug discovery with cutting-edge machine learning techniques. Prescient Design is developing cutting-edge machine learning for drug discovery, building new methods, techniques, and systems to fundamentally transform how drugs are designed. We are seeking a highly motivated Machine Learning Scientist to help drive research on Machine Learning for Drug Discovery, with a focus on Small Molecule Drug Discovery (SMDD). The successful candidate will develop, deploy, and deliver innovative ML solutions that accelerate molecular design, prediction, and hypothesis generation, working closely with computational and experimental collaborators across gRED and Roche.
**In this role, you will:**
+ Design, build, and apply machine learning methods to key challenges in small molecule drug discovery, including molecular property prediction, protein-ligand modeling, chemical reactivity, and synthesizability.
+ Develop robust and scalable ML pipelines that integrate with cheminformatics, structural biology, and computational chemistry tools.
+ Collaborate with computational chemists, medicinal chemists, structural biologists, and experimental scientists to generate testable hypotheses and guide design decisions.
+ Curate, integrate, and leverage diverse biochemical, biophysical, and chemical datasets to power ML models and workflows.
+ Explore and apply a range of ML approaches - from deep learning (transformers, graph neural networks) to physics-informed and hybrid methods - for impactful applications in drug discovery.
+ Deploy models and workflows into production research environments, ensuring reproducibility and scalability.
+ Contribute to and drive publications, present results at internal and external scientific conferences, and help make code and workflows open source.
**Who you are**
+ You have a PhD in the physical sciences (e.g., Chemistry, Physics, Chemical Engineering) or quantitative fields (e.g., Computer Science, Statistics, Applied Mathematics) with 0 - 3 years experience, or equivalent industry research experience.
+ You have a strong background in scientific software development and ML engineering, with demonstrated ability to design, train, and deploy ML models.
+ You have experience working with biochemical, chemical, or biophysical datasets; familiarity with cheminformatics and small molecule drug discovery concepts.
+ You are fluent in Python and experience with modern ML frameworks (e.g., PyTorch, JAX, TensorFlow, Hugging Face)
+ You have a familiarity with commonly used toolkits for chemical modeling (e.g., RDKit, OpenEye, OpenMM, Schrodinger)
Preferred
+ Experience with cloud platforms (AWS, GCP, or Azure), version control (Git), and CI/CD pipelines.
+ Record of scientific excellence as evidenced by at least multiple publications in a scientific journal or conference.
+ Public portfolio of projects available on GitHub/GitLab is a plus.
Relocation benefits are available for this job posting.
The expected salary range for this position, based on the location of California, is $167,400 - 310,800. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits ( is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants ( .

Our client is seeking an innovative and experienced Senior Research Scientist to join their cutting-edge Pharmaceutical R&D department in San Francisco, California, US . This role is pivotal in driving drug discovery initiatives, focusing on identifying and validating novel therapeutic targets and developing small molecule or biologic drug candidates. The ideal candidate will possess a strong background in medicinal chemistry, pharmacology, or a related discipline, with a proven track record of success in early-stage drug discovery. This hybrid position offers the opportunity to collaborate with a world-class scientific team while maintaining flexibility.

Responsibilities:

• Lead and execute research projects focused on identifying and validating novel drug targets.
• Design and synthesize potential drug candidates using medicinal chemistry principles.
• Conduct in vitro and in vivo pharmacology studies to evaluate the efficacy and safety of drug candidates.
• Develop and optimize assays for drug screening and characterization.
• Analyze and interpret complex experimental data, drawing sound conclusions and proposing next steps.
• Collaborate closely with cross-functional teams, including biologists, chemists, toxicologists, and clinical scientists.
• Prepare scientific reports, publications, and presentations for internal and external audiences.
• Stay abreast of the latest scientific literature and technological advancements in drug discovery.
• Contribute to the strategic planning of the drug discovery pipeline.
• Mentor junior scientists and provide technical expertise.
• Manage external research collaborations and CROs as needed.

Qualifications:

• Ph.D. in Medicinal Chemistry, Pharmacology, Biochemistry, or a related life science field.
• Minimum of 5 years of post-doctoral research experience in the pharmaceutical or biotech industry.
• Demonstrated expertise in a specific therapeutic area (e.g., oncology, immunology, neuroscience) is highly desirable.
• Proven experience in small molecule or biologic drug design and discovery.
• Proficiency in modern drug discovery techniques, including high-throughput screening, structure-based drug design, and PK/PD studies.
• Strong analytical and problem-solving skills with meticulous attention to detail.
• Excellent written and oral communication skills.
• Ability to work collaboratively in a fast-paced, team-oriented environment within San Francisco, California, US , with a hybrid work model.

Our client, a pioneering biopharmaceutical company at the forefront of developing novel therapeutics, is seeking an exceptional Principal Research Scientist, Drug Discovery to join our innovative, fully remote research team. This role is crucial for driving our drug discovery programs from target identification through to preclinical candidate selection. You will be responsible for designing and executing complex research strategies, leading independent projects, and mentoring junior scientists. The ideal candidate will possess a deep understanding of molecular biology, pharmacology, and medicinal chemistry, with a proven history of successful contributions to drug discovery pipelines.

As a Principal Research Scientist, you will spearhead innovative research initiatives, developing and implementing cutting-edge experimental methodologies to identify and validate novel therapeutic targets. Your expertise will be vital in characterizing lead compounds, assessing their efficacy and safety profiles, and advancing promising candidates through the discovery pipeline. You will collaborate extensively with internal cross-functional teams, including computational chemistry, DMPK, and toxicology, as well as external academic collaborators and contract research organizations (CROs). This fully remote position requires exceptional self-discipline, strong communication skills, and the ability to work autonomously while contributing effectively to a distributed team. You will be expected to stay abreast of the latest scientific literature, present research findings at scientific conferences, and contribute to publications and patent applications. We seek a scientifically rigorous and creative individual who can solve complex biological problems and drive the discovery of life-changing medicines. Join our virtual labs and contribute to groundbreaking advancements in pharmaceutical research, all from your home office. The impact of your work will be felt globally.

Qualifications:

• Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or a related life science discipline.
• Minimum of 10 years of post-doctoral research experience in drug discovery within the pharmaceutical or biotechnology industry.
• Demonstrated success in leading independent research projects and delivering preclinical candidates.
• Extensive knowledge of target identification and validation, assay development, and small molecule/biologics drug discovery principles.
• Proficiency in modern molecular and cellular biology techniques.
• Strong understanding of medicinal chemistry, PK/PD, and early toxicology principles.
• Excellent scientific writing, presentation, and communication skills.
• Proven ability to collaborate effectively with cross-functional teams and external partners.
• Experience in managing research projects and mentoring junior scientists.
• A passion for scientific innovation and a commitment to bringing new therapies to patients.

Our client is seeking a highly accomplished and innovative Principal Research Scientist to join their cutting-edge drug discovery team in San Francisco, California, US . This senior-level position is crucial for leading research initiatives, developing novel therapeutic strategies, and contributing significantly to the advancement of our client's pipeline. The ideal candidate will possess a strong background in molecular biology, pharmacology, or a related discipline, coupled with extensive experience in identifying and validating drug targets. This role demands a scientifically rigorous approach, a passion for innovation, and the ability to mentor junior scientists. Key responsibilities include designing and executing complex experiments, analyzing research data, and interpreting results to guide future research directions. You will be responsible for staying abreast of the latest scientific literature and technological advancements in the field of drug discovery. The Principal Research Scientist will also play a key role in project management, resource allocation, and the preparation of research reports and publications. Collaboration with cross-functional teams, including chemistry, toxicology, and clinical development, will be essential for successful project progression. This hybrid role offers a dynamic balance between laboratory-based research and collaborative in-office work, fostering both deep scientific inquiry and team synergy. Qualifications:

• Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or a related life science field.
• Minimum of 10 years of post-doctoral research experience in drug discovery or a related pharmaceutical setting.
• Proven track record of successful drug target identification, validation, and early-stage development.
• Extensive experience with relevant biological assays, molecular biology techniques, and cell-based models.
• Strong understanding of disease pathophysiology and therapeutic intervention strategies.
• Excellent leadership, mentoring, and team management skills.
• Exceptional analytical, problem-solving, and critical thinking abilities.
• Strong publication record in peer-reviewed journals.
• Excellent written and verbal communication skills, with the ability to present complex scientific data effectively.
• Experience with (mention specific therapeutic area, e.g., oncology, immunology) is highly desirable.

This is an exceptional opportunity for a visionary scientist to make a significant contribution to developing life-changing medicines.

Our client, a leading biopharmaceutical company, is seeking a highly accomplished Principal Research Scientist to lead innovative drug discovery initiatives. This is a fully remote position, offering the opportunity to contribute to groundbreaking research from your home office.

As a Principal Research Scientist, you will spearhead cutting-edge research programs focused on identifying and validating novel therapeutic targets and developing innovative small molecules and biologics. You will be responsible for designing and executing complex experiments, analyzing data, and translating findings into actionable drug development strategies. This role requires a deep understanding of disease biology, medicinal chemistry, and pharmacology, along with exceptional leadership and mentorship skills.

Key Responsibilities:

• Lead and manage drug discovery projects from target identification through lead optimization.
• Design and conduct in vitro and in vivo studies to evaluate the efficacy and safety of potential drug candidates.
• Utilize state-of-the-art techniques in molecular biology, biochemistry, cell biology, and pharmacology.
• Analyze and interpret complex experimental data, drawing sound conclusions and making strategic recommendations.
• Collaborate with cross-functional teams, including chemists, biologists, toxicologists, and clinical development specialists.
• Write and present research findings internally and externally at scientific conferences and in peer-reviewed publications.
• Mentor and guide junior scientists, fostering a collaborative and productive research environment.
• Contribute to the company's intellectual property portfolio by identifying and patenting novel discoveries.
• Stay abreast of the latest advancements in pharmaceutical research and relevant therapeutic areas.
• Ensure compliance with all laboratory safety regulations and ethical guidelines.

Qualifications:

• Ph.D. in Pharmacology, Molecular Biology, Biochemistry, or a related life science discipline.
• Minimum of 10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
• Demonstrated track record of successfully advancing drug candidates through discovery and early development phases.
• Extensive expertise in relevant disease areas (e.g., oncology, immunology, neurology).
• Strong hands-on experience with various assay development, screening technologies, and preclinical models.
• Proven ability to design, execute, and interpret complex biological experiments.
• Excellent leadership, communication, and presentation skills, with the ability to mentor and inspire a research team.
• Proficiency in data analysis software and scientific literature databases.
• Experience working effectively in a remote research setting is essential.
• Strong publication record in high-impact journals.

This is a critical role for an experienced scientist seeking to make a significant impact on patient lives through innovative drug development, leveraging the flexibility of a fully remote position.

Our client, a leading biopharmaceutical innovator, is seeking a highly skilled and motivated Senior Medicinal Chemist to join their dynamic Drug Discovery team in **San Francisco, California, US**. This role offers a unique opportunity to contribute to the development of groundbreaking therapies that address unmet medical needs. The successful candidate will play a pivotal role in the design, synthesis, and optimization of novel small molecule drug candidates. Responsibilities include: leading hit-to-lead and lead optimization campaigns, developing innovative synthetic routes for complex molecules, employing structure-activity relationship (SAR) studies to guide chemical modifications, collaborating closely with biologists, pharmacologists, and DMPK scientists to drive project progression, and presenting research findings at internal and external meetings.

We are looking for an individual with a Ph.D. in Organic Chemistry or Medicinal Chemistry, with a strong track record of success in drug discovery within the pharmaceutical or biotechnology industry. A minimum of 5 years of relevant post-doctoral or industry experience is required. Essential skills include expert knowledge of synthetic organic chemistry, proficiency in modern drug discovery techniques and analytical methods (NMR, LC-MS, HPLC), and experience with medicinal chemistry software and databases. The ideal candidate will possess excellent problem-solving abilities, strong communication and interpersonal skills, and the capacity to work independently and as part of a multidisciplinary team. Familiarity with computational chemistry tools and techniques is a plus. This position is based in our vibrant **San Francisco, California, US** office, with a hybrid work arrangement, allowing for a flexible balance between in-office collaboration and remote work. Join us and make a significant impact on the future of medicine.