8,955 Drug Discovery jobs in the United States

Research Scientist - Drug Discovery

95814 Sacramento, California $120000 Annually WhatJobs

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full-time
Our client, a cutting-edge pharmaceutical company dedicated to developing life-saving therapies, is seeking a talented and innovative Research Scientist to join their Drug Discovery team in **Sacramento, California, US**. This role is crucial for advancing novel therapeutic candidates from discovery through preclinical development.

As a Research Scientist, you will design and execute experiments, analyze complex biological data, and contribute to the strategic direction of drug discovery programs. You will work in a state-of-the-art laboratory environment, collaborating with a multidisciplinary team of scientists and clinicians. Key responsibilities include:
  • Designing and implementing experimental strategies to identify and validate drug targets.
  • Performing biochemical, cellular, and in vivo assays to assess compound efficacy and safety.
  • Analyzing and interpreting experimental data using appropriate statistical methods.
  • Troubleshooting experimental issues and optimizing assay conditions.
  • Contributing to the design and synthesis of small molecule drug candidates.
  • Writing detailed experimental protocols, reports, and manuscripts for publication.
  • Presenting research findings at internal meetings and external conferences.
  • Collaborating effectively with medicinal chemists, pharmacologists, and toxicologists.
  • Maintaining accurate laboratory notebooks and records.
  • Staying current with the latest scientific literature and technologies in relevant fields.
  • Mentoring junior scientists and research associates.
  • Contributing to the intellectual property strategy through invention disclosures.
  • Ensuring compliance with all laboratory safety regulations and protocols.
  • Managing external collaborations with academic institutions or CROs.
  • Assisting in the preparation of regulatory submission documents.

Required Qualifications:
  • Ph.D. in Pharmacology, Biochemistry, Molecular Biology, or a related discipline.
  • 3-5 years of postdoctoral or industry experience in drug discovery.
  • Proven expertise in relevant biological assays (e.g., enzyme assays, cell-based assays, screening platforms).
  • Strong understanding of disease biology and relevant therapeutic areas.
  • Experience with small molecule drug discovery is highly desirable.
  • Proficiency in data analysis software (e.g., GraphPad Prism, R).
  • Excellent written and oral communication skills, with a track record of publications.
  • Demonstrated ability to think critically and solve complex scientific problems.
  • Strong teamwork and collaboration skills.
  • Ability to manage multiple projects and prioritize effectively.
  • Experience with animal models is a plus.

This is a unique opportunity to make a significant impact on patient lives by contributing to the development of innovative medicines. Our client offers a competitive compensation package, excellent benefits, and a stimulating research environment.
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Research Scientist - Drug Discovery

84101 Salt Lake City, Utah $125000 Annually WhatJobs

Posted 7 days ago

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full-time
Our client, a leading pharmaceutical research organization, is seeking a talented Research Scientist to join their Drug Discovery team in Salt Lake City, Utah, US . This role offers a dynamic hybrid work environment, allowing for focused research in the lab complemented by remote work flexibility. The successful candidate will play a critical role in identifying and validating novel therapeutic targets and developing innovative drug candidates. This position requires a strong background in molecular biology, biochemistry, or a related field, coupled with hands-on experience in drug discovery methodologies. You will collaborate with a multidisciplinary team of scientists to advance projects from early-stage research through preclinical development.

Responsibilities:
  • Design and execute experiments to identify and characterize novel drug targets and pathways.
  • Develop and implement various biochemical and cellular assays for compound screening and validation.
  • Analyze experimental data, interpret results, and generate comprehensive reports.
  • Collaborate with medicinal chemists, pharmacologists, and other research scientists to advance drug discovery programs.
  • Contribute to the design and optimization of preclinical studies.
  • Stay current with the latest scientific literature and technological advancements in relevant therapeutic areas.
  • Maintain accurate and detailed laboratory notebooks and contribute to regulatory filings.
  • Present research findings at internal meetings and external scientific conferences.
  • Troubleshoot experimental issues and propose solutions.
  • Contribute to the development of intellectual property through patent applications.
Qualifications:
  • Ph.D. in Molecular Biology, Biochemistry, Pharmacology, or a related life science discipline.
  • 3-5 years of postdoctoral or industry experience in drug discovery or a related field.
  • Proven experience with a range of biochemical and cell-based assay development and execution (e.g., ELISA, Western Blot, High-Throughput Screening).
  • Strong understanding of drug discovery processes and principles.
  • Excellent analytical and problem-solving skills.
  • Proficiency in data analysis software (e.g., GraphPad Prism, R).
  • Strong written and oral communication skills.
  • Ability to work effectively in a hybrid setting, collaborating with both lab-based and remote colleagues.
  • Experience with specific therapeutic areas (e.g., oncology, immunology) is a plus.
  • Demonstrated ability to work independently and as part of a team.
This is an exciting opportunity to contribute to groundbreaking research and make a real difference in patient lives.
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Research Scientist, Drug Discovery

94043 San Jose, California $120000 Annually WhatJobs

Posted 7 days ago

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full-time
Our client, a leading pharmaceutical innovator, is seeking a highly skilled and motivated Research Scientist to join our cutting-edge drug discovery team based in San Jose, California, US . This critical role involves designing and executing experiments to identify and validate novel therapeutic targets and drug candidates. You will contribute to the development of innovative treatments for unmet medical needs, working at the forefront of pharmaceutical research. The ideal candidate will possess a strong background in molecular biology, biochemistry, or a related discipline, with hands-on experience in relevant assay development, screening, and data analysis. Responsibilities will include planning and conducting laboratory experiments, interpreting complex data sets, and presenting findings to cross-functional teams. You will collaborate closely with medicinal chemists, pharmacologists, and computational biologists to advance drug discovery programs. A key aspect of this role involves staying abreast of the latest scientific literature and technological advancements in the field. You should be proficient in a range of molecular and cellular biology techniques, including but not limited to, cell-based assays, protein biochemistry, molecular cloning, and genetic manipulation. Experience with high-throughput screening (HTS) platforms and data analysis software is highly desirable. A Ph.D. in a relevant scientific discipline is required, coupled with a strong publication record and experience in the pharmaceutical or biotechnology industry. We are looking for individuals with excellent problem-solving abilities, a meticulous approach to research, and the capacity to work independently as well as part of a collaborative team. This position offers a stimulating research environment, opportunities for professional growth, and the chance to make a significant impact on patient lives. Join our dedicated team and contribute to the next generation of life-saving medicines.
Primary Responsibilities:
  • Design, optimize, and execute complex biological assays for target identification and validation.
  • Conduct experiments using various molecular and cellular biology techniques.
  • Analyze and interpret experimental data, generating clear and concise reports.
  • Collaborate with multidisciplinary teams, including medicinal chemistry and pharmacology, to advance drug discovery programs.
  • Stay current with scientific literature and emerging technologies in relevant therapeutic areas.
  • Contribute to the development and implementation of new research strategies and methodologies.
  • Present research findings at internal team meetings and potentially at external scientific conferences.
  • Maintain accurate and detailed laboratory notebooks and records.
Qualifications:
  • Ph.D. in Molecular Biology, Biochemistry, Pharmacology, or a related life science field.
  • 3+ years of postdoctoral or industry experience in drug discovery or a related area.
  • Demonstrated expertise in assay development, screening, and data analysis.
  • Proficiency in a broad range of molecular and cellular biology techniques.
  • Experience with HTS platforms and associated data analysis tools is a strong plus.
  • Excellent analytical, problem-solving, and critical thinking skills.
  • Strong written and verbal communication skills, with the ability to present complex data effectively.
  • Ability to work independently and collaboratively in a team-oriented research environment.
  • Prior experience in a pharmaceutical or biotechnology setting is preferred.
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Principal Scientist - Drug Discovery & Development

35801 Huntsville, Alabama $140000 Annually WhatJobs

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full-time
Our client, a leading biopharmaceutical company, is seeking a highly accomplished Principal Scientist to drive innovation in drug discovery and development. This is a fully remote, high-impact role where you will contribute to the advancement of novel therapeutics from target identification through preclinical development. The ideal candidate will possess a deep scientific expertise in (mention relevant therapeutic area, e.g., oncology, immunology, infectious diseases), a proven track record in medicinal chemistry or related disciplines, and a passion for translating scientific breakthroughs into life-changing medicines.

As a Principal Scientist, you will be responsible for designing and executing complex research strategies to identify and optimize lead compounds. Your duties will include managing research projects, analyzing and interpreting experimental data, and contributing to the development of robust preclinical packages. You will collaborate closely with cross-functional teams, including biologists, pharmacologists, toxicologists, and clinical development experts, to guide drug candidates through the development pipeline. Expertise in small molecule discovery, protein-ligand interactions, and structure-activity relationship (SAR) analysis is highly valued.

Key responsibilities will involve staying abreast of the latest scientific advancements and emerging technologies in drug discovery. You will critically evaluate new research opportunities, contribute to intellectual property strategies, and prepare high-quality scientific reports, publications, and presentations. The Principal Scientist will also play a key role in mentoring junior scientists, fostering a collaborative and innovative research environment, and contributing to the strategic direction of the R&D organization. Ensuring compliance with all relevant regulatory guidelines and ethical standards is paramount.

To be considered for this role, you must hold a Ph.D. in Medicinal Chemistry, Organic Chemistry, Pharmacology, or a related life science field. A minimum of 8 years of post-doctoral research experience in the pharmaceutical or biotechnology industry, with a strong focus on drug discovery and preclinical development, is required. Demonstrable success in leading research projects and contributing to the advancement of drug candidates into clinical trials is essential. Expertise in (mention specific techniques or areas like in vitro assays, PK/PD studies, computational chemistry) is highly desirable. Excellent analytical, critical thinking, and problem-solving skills are crucial. Superior written and verbal communication skills, with the ability to effectively present complex scientific information to diverse audiences, are necessary. This is a remote-first position demanding self-motivation, strong project management skills, and the ability to thrive in a collaborative, virtual setting.
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Principal Scientist, Drug Discovery & Development

23451 Virginia Beach, Virginia $160000 Annually WhatJobs

Posted 1 day ago

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full-time
Our client, a leading pharmaceutical innovator, is seeking a highly motivated and experienced Principal Scientist to spearhead critical initiatives in drug discovery and development. This is a premier fully remote opportunity for a visionary scientist to contribute to the advancement of novel therapeutics. You will play a pivotal role in designing and executing cutting-edge research programs, identifying and validating novel drug targets, and developing innovative small molecule or biologic drug candidates. Your expertise will guide the early-stage development pipeline, from target identification through preclinical candidate selection.

Key responsibilities include leading complex research projects, mentoring junior scientists, and fostering a collaborative research environment. You will be responsible for the design and interpretation of experiments, ensuring rigorous scientific methodology and data integrity. This role involves close collaboration with cross-functional teams, including medicinal chemistry, biology, pharmacology, DMPK, and toxicology, to advance drug candidates through the development process. You will also be expected to present research findings at internal meetings and external scientific conferences, and contribute to the preparation of regulatory filings and patent applications. The successful candidate will contribute to shaping the scientific strategy and identifying new opportunities for innovation within the company's therapeutic areas of focus.

The ideal candidate will possess a Ph.D. in a relevant scientific discipline (e.g., Molecular Biology, Pharmacology, Biochemistry, Immunology) with a minimum of 8-12 years of post-doctoral research experience in the pharmaceutical or biotechnology industry. A proven track record of successful drug discovery and development, evidenced by publications, patents, and successful progression of candidates, is essential. Expertise in specific therapeutic areas (e.g., oncology, immunology, infectious diseases) is highly desirable. Strong leadership, project management, and communication skills are critical. Experience with data analysis software and a deep understanding of modern drug discovery technologies are required. This role is designed for an independent, results-oriented scientist who thrives in a remote setting and can effectively collaborate across geographically dispersed teams. Our client offers a challenging yet rewarding remote work environment with opportunities for scientific leadership and professional advancement.
Location: This position is fully remote, based within the United States.
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Principal Scientist - Drug Discovery & Development

46201 Indianapolis, Indiana $170000 Annually WhatJobs

Posted 4 days ago

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full-time
Our client, a cutting-edge pharmaceutical company dedicated to revolutionizing patient care through innovative therapeutics, is seeking a highly accomplished Principal Scientist to join their esteemed Research and Development division. This is a critical, fully remote position focused on advancing early-stage drug discovery through to preclinical development. You will play a pivotal role in designing and executing complex research projects, analyzing data, and contributing to the strategic direction of new drug candidates. The ideal candidate possesses a deep scientific understanding, exceptional problem-solving skills, and a passion for making a tangible impact on human health.

Key Responsibilities:
  • Lead and manage research projects focused on identifying and validating novel therapeutic targets and drug candidates.
  • Design and execute rigorous experiments using a variety of biological and biochemical assays.
  • Analyze complex datasets, interpret results, and draw robust scientific conclusions.
  • Develop and optimize preclinical models for assessing drug efficacy and safety.
  • Collaborate with medicinal chemists, pharmacologists, and toxicologists to advance drug candidates through the development pipeline.
  • Stay current with scientific literature, emerging technologies, and industry trends in relevant therapeutic areas.
  • Write and present research findings to internal teams, management, and at scientific conferences.
  • Contribute to the preparation of regulatory submissions (e.g., IND filings).
  • Mentor and guide junior scientists, fostering a collaborative and innovative research environment.
  • Manage external collaborations with academic institutions and CROs.
  • This is a fully remote position, requiring significant autonomy, strong project management skills, and effective virtual communication.

Qualifications:
  • Ph.D. in Pharmacology, Molecular Biology, Biochemistry, or a closely related field.
  • Minimum of 10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
  • Proven track record of successfully contributing to drug discovery and development programs.
  • Extensive experience with a wide range of in vitro and in vivo experimental techniques relevant to drug discovery.
  • Strong understanding of disease biology and therapeutic mechanisms in relevant therapeutic areas.
  • Expertise in data analysis and interpretation using statistical software and bioinformatics tools.
  • Demonstrated leadership ability and experience mentoring scientific staff.
  • Excellent written and verbal communication skills, with a strong publication record.
  • Ability to think critically, solve complex scientific problems, and work independently.
  • Familiarity with regulatory requirements for drug development is highly desirable.
This role offers an unparalleled opportunity to contribute to the development of life-changing medicines from the comfort of your home office. You will be integral to shaping the future of our client's therapeutic pipeline, working on challenging and impactful science. While the role is remote, our operational nexus for this research area is often coordinated with activities relevant to Indianapolis, Indiana, US .
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Principal Scientist, Drug Discovery & Development

23218 Richmond, Virginia $150000 Annually WhatJobs

Posted 4 days ago

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full-time
Our client, a leading pharmaceutical company dedicated to advancing human health, is seeking a highly accomplished Principal Scientist to join their innovative Drug Discovery & Development team. This vital, on-site role is based at their state-of-the-art research facility in Richmond, Virginia, US . You will play a pivotal role in conceptualizing, designing, and executing research programs aimed at identifying and developing novel therapeutic candidates. The ideal candidate will possess a deep understanding of molecular biology, pharmacology, and drug development processes, with a proven track record of scientific excellence and leadership in a pharmaceutical or biotech setting. You will collaborate closely with cross-functional teams, including chemists, biologists, and clinical researchers, to advance drug candidates through the development pipeline. Responsibilities include:
  • Designing and leading innovative research projects in early-stage drug discovery.
  • Developing and validating novel assays and experimental models to assess target engagement and efficacy.
  • Conducting in-depth analysis of biological data and interpreting results to inform project direction.
  • Guiding and mentoring junior scientists and research associates.
  • Collaborating with medicinal chemists to optimize lead compounds.
  • Planning and overseeing preclinical studies to assess drug safety and efficacy.
  • Preparing and presenting research findings at internal meetings and scientific conferences.
  • Contributing to the development of scientific strategy and pipeline prioritization.
  • Ensuring compliance with all relevant regulatory guidelines and safety protocols.
  • Staying abreast of the latest scientific advancements and emerging technologies in pharmaceutical research.

A Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or a related life science discipline is required, coupled with a minimum of 8 years of post-doctoral research experience in drug discovery within the pharmaceutical or biotechnology industry. Extensive experience in target validation, assay development, and preclinical drug evaluation is essential. A strong publication record and a proven ability to lead independent research programs are mandatory. Excellent leadership, communication, and problem-solving skills are crucial for this role. This position requires full-time dedication and on-site presence.
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Principal Scientist - Drug Discovery & Development

80202 Denver, Colorado $180000 Annually WhatJobs

Posted 5 days ago

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full-time
Our client, a leading pharmaceutical innovator, is seeking a highly accomplished Principal Scientist to join their cutting-edge drug discovery and development team. This is a fully remote position, offering a unique opportunity to contribute to groundbreaking research from anywhere. You will play a pivotal role in identifying and validating novel therapeutic targets, designing and executing preclinical studies, and advancing drug candidates through the pipeline. The ideal candidate will possess a Ph.D. in a relevant scientific discipline (e.g., pharmacology, molecular biology, biochemistry), coupled with extensive experience in pharmaceutical R&D. A deep understanding of disease mechanisms, target validation strategies, and early-stage drug development is essential. You will be expected to lead scientific initiatives, mentor junior researchers, and collaborate effectively with multidisciplinary teams. Strong publication records and experience with grant writing are highly desirable. This role requires exceptional critical thinking, problem-solving skills, and a passion for scientific innovation. As a remote-first position, you will need to demonstrate strong self-management, excellent communication abilities, and the capacity to contribute meaningfully within a virtual collaborative environment. You will be instrumental in shaping the scientific direction of discovery programs and ensuring the timely progression of promising drug candidates towards clinical trials.

Key Responsibilities:
  • Lead scientific research initiatives in drug discovery and development.
  • Identify and validate novel therapeutic targets for unmet medical needs.
  • Design and oversee preclinical studies to assess drug efficacy and safety.
  • Interpret complex experimental data and draw insightful conclusions.
  • Develop and implement innovative research strategies and methodologies.
  • Mentor and guide junior scientists and research associates.
  • Collaborate effectively with internal and external collaborators, including CROs.
  • Prepare scientific reports, manuscripts for publication, and presentations.
  • Contribute to the strategic planning and direction of R&D programs.
  • Stay abreast of the latest scientific advancements and emerging technologies in the field.
Qualifications:
  • Ph.D. in Pharmacology, Molecular Biology, Biochemistry, or a related life science discipline.
  • 10+ years of post-doctoral and industry experience in pharmaceutical drug discovery and development.
  • Proven track record of leading successful R&D projects and delivering data packages for progression.
  • Expertise in relevant therapeutic areas and target validation strategies.
  • Extensive experience with in vitro and in vivo experimental models.
  • Strong publication record in peer-reviewed journals.
  • Excellent leadership, communication, and interpersonal skills.
  • Experience managing remote research teams and collaborating in a virtual setting.
  • Proficiency in scientific data analysis and interpretation.
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Principal Scientist, Drug Discovery & Development

63101 St. Louis, Missouri $155000 Annually WhatJobs

Posted 7 days ago

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full-time
Our client, a cutting-edge pharmaceutical company committed to improving global health, is actively recruiting a Principal Scientist to lead critical drug discovery and development initiatives. This fully remote position offers an unparalleled opportunity to shape the future of medicine from your home office. You will be responsible for driving innovation in early-stage drug discovery, identifying novel therapeutic targets, and developing robust preclinical drug candidates. This includes designing and executing complex biological assays, leading in vivo and in vitro studies, and critically evaluating experimental data. The ideal candidate will possess deep expertise in a relevant therapeutic area (e.g., oncology, immunology, infectious diseases) and a strong understanding of modern drug discovery technologies. You will collaborate closely with cross-functional teams, including medicinal chemistry, DMPK, and toxicology, to advance programs from target identification through to IND submission. Responsibilities also encompass staying abreast of scientific literature, identifying emerging trends, and contributing to intellectual property strategy. A strong publication record, experience with bioinformatics tools, and a proven ability to manage research projects independently are essential. You will mentor junior scientists, contribute to project planning, and present research findings to internal and external audiences. This remote role requires exceptional scientific rigor, problem-solving skills, and the ability to thrive in a fast-paced, collaborative research environment. Join us in making a significant impact on patient lives worldwide. This role is associated with **St. Louis, Missouri, US**, and is performed remotely.
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Principal Scientist, Drug Discovery & Development

94043 San Jose, California $220000 Annually WhatJobs

Posted 7 days ago

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full-time
Our client, a leading pharmaceutical research and development company, is seeking a highly accomplished Principal Scientist to join their innovative team. This is a fully remote, pivotal role focused on advancing cutting-edge drug discovery and development programs. You will lead independent research projects, conceptualize novel therapeutic strategies, and drive the identification and validation of new drug targets. The ideal candidate will possess a deep scientific expertise in a relevant therapeutic area (e.g., oncology, immunology, neuroscience), coupled with a proven track record of successfully translating scientific discoveries into preclinical candidates. Responsibilities include designing and executing complex experiments, analyzing large datasets, interpreting results, and presenting findings to scientific leadership and project teams. You will play a key role in guiding cross-functional teams, mentoring junior scientists, and fostering a collaborative research environment. A strong understanding of medicinal chemistry, pharmacology, and translational research principles is essential. This position requires exceptional critical thinking, problem-solving abilities, and the capacity to independently manage multiple research initiatives. We are looking for a strategic scientific leader who can contribute significantly to our pipeline and shape the future of therapeutic innovation. This is a unique opportunity to work on challenging projects in a fully remote setting, with the flexibility to contribute from anywhere while making a profound impact on patient lives. Our client is committed to a remote-first culture, providing the necessary resources and support for remote employees to thrive and achieve scientific breakthroughs.

Key Responsibilities:
  • Lead independent research projects focused on drug discovery and development.
  • Conceptualize, design, and execute complex biological assays and experiments.
  • Identify and validate novel drug targets and therapeutic strategies.
  • Analyze and interpret experimental data, drawing meaningful conclusions.
  • Guide and mentor junior scientists and research associates.
  • Collaborate with cross-functional teams, including medicinal chemistry, pharmacology, and toxicology.
  • Prepare and present research findings at internal meetings and external scientific conferences.
  • Contribute to the strategic direction of drug discovery programs.
  • Maintain a thorough understanding of the scientific literature and emerging technologies in relevant therapeutic areas.
  • Author scientific publications and patent applications.
Qualifications:
  • Ph.D. in Molecular Biology, Biochemistry, Pharmacology, Immunology, or a related life science discipline.
  • Minimum of 10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
  • Proven track record of success in drug discovery and development, with significant contributions to pipeline progression.
  • Expertise in designing and executing complex biological assays and experimental models.
  • Deep understanding of disease biology, target validation, and early-stage drug development.
  • Strong analytical and problem-solving skills, with the ability to interpret complex biological data.
  • Excellent written and verbal communication skills, with experience in scientific writing and presentations.
  • Demonstrated ability to lead research projects and mentor scientific staff.
  • Proficiency in relevant scientific software and data analysis tools.
  • Ability to work independently and effectively in a fully remote research environment.
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