9,142 Principal Scientist jobs in the United States

This range is provided by BioPhase. Your actual pay will be based on your skills and experience talk with your recruiter to learn more.

Base pay range

$150,000.00/yr - $90,000.00/yr

Direct message the job poster from BioPhase

Principal Scientist-Proteomics & Metabolomics

Summary

This role is a pivotal partner to laboratory operations leadership, driving client success, and communicating transformative biological insights to our customers. Within this capacity, steer study design, project plans, and orchestrate seamless handoff of information from scientific partners to laboratory personnel. Scope of influence extends to bolstering the evolution and upkeep of quality systems while championing client projects.

Additional tasks include review of mass spectral data and analyses, preparation of figures and tables for final data presentations and publication, compiling data packages and results for release to clients.

Responsibilities

• Collaborate with top-tier thinkers and experts that promote personal and professional growth through enriching training initiatives.
• Project management between the client and within the wet- and dry-lab to ensure deliverables are being met and troubleshooting when necessary.
• Develop research strategies, study plans and reports for projects.
• Review mass spectrometry spectra and perform compound identification.
• Ensure results are generated to the appropriate quality and regulatory standards for their intended purpose.
• Compile data and results into final presentations and data packages.
• Prioritization, organization, and understanding of numerous projects to ensure timelines and deliverables are met.
• Interpretation of scientific results.
• Remain current with scientific literature and technological advancements.

Experience

• At least 5 years of experience in pharmaceuticals and/or biotechnology, with expertise in mass spectrometry techniques.
• 5 years of management experience.
• Has a strong background in metabolomics and proteomics methodologies, including mass spectrometry, and data analysis.
• Ability to manage many tasks in parallel, complete projects on time, and work well in a team setting.
• Possesses a strong analytical mindset to interpret complex data and draw meaningful conclusions.
• Thrives in collaborative environments, capable of working seamlessly with multidisciplinary teams that may include biologists, chemists, clinicians, software engineers, and data scientists.
• Exhibits meticulousness in work product to ensure accurate and reliable results.
• Keeps up-to-date with the latest advancements in precision medicine.
• Can articulate complex scientific concepts in a clear and concise manner, both in writing and in presentations.
• Effective at collaborating with peers, mentoring junior researchers, and participating in scientific discussions.

Education

• PhD in a relevant field and 5+ years
• MS and 8+years relevant experience.

Seniority level

• Seniority level Mid-Senior level

Employment type

• Employment type Full-time

Job function

• Job function Research
• Industries Pharmaceutical Manufacturing and Biotechnology Research

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Medical insurance

Vision insurance

401(k)

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Senior Scientist, Analytical Development Senior Clinical Scientist, Clinical Development Senior Director, RWE/Epi Scientist Internal Medicine Principal Scientist, Medicinal Chemistry Associate Scientist I, Formulation Development Principal Environmental Planner/Scientist Senior Scientist/Principal Scientist, Computational Immunology Scientist/Senior Scientist, Computational Drug Design

San Diego Metropolitan Area 130,000.00- 155,000.00 3 days ago

San Diego County, CA 60.00- 80.00 3 weeks ago

Scientist / Senior Scientist, Computational Biology Senior ML Scientist, Amazon Games AI Research

San Diego, CA 150,400.00- 260,000.00 18 hours ago

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Job Description

Mission Support and Test Services, LLC (MSTS) manages and operates the Nevada National Security Site (NNSS) for the U.S. National Nuclear Security Administration (NNSA). Our MISSION is to help ensure the security of the United States and its allies by providing high-hazard experimentation and incident response capabilities through operations, engineering, education, field, and integration services and by acting as environmental stewards to the Site's Cold War legacy. Our VISION is to be the user site of choice for large-scale, high-hazard, national security experimentation, with premier facilities and capabilities below ground, on the ground, and in the air. (See NNSS.gov for our unique capabilities.) Our 2,750+ professional, craft, and support employees are called upon to innovate, collaborate, and deliver on some of the more difficult nuclear security challenges facing the world today.

• MSTS offers our full-time employees highly competitive salaries and benefits packages including medical, dental, and vision; both a pension and a 401k; paid time off and 96 hours of paid holidays; relocation (if located more than 75 miles from work location); tuition assistance and reimbursement; and more.
• MSTS is a limited liability company consisting of Honeywell International Inc. (Honeywell), Jacobs Engineering Group Inc. (Jacobs), and HII Nuclear Inc.

Responsibilities

The Remote Sensing Laboratory, located on Joint Base Andrews in Maryland, is searching for an enthusiastic and energetic individual looking to join our dynamic emergency response organization that is responsible for supporting several national-level emergency response assets. The selected candidate will be expected to:

Key Responsibilities

• Collect and analyze radiological data from a variety of platforms, and advise public safety officials on the consequences of a radiological incident.
• Utilize specialized tools and applications to calculate potential impact to the public, workers, and the environment to support radiological emergencies.
• Attain and maintain qualifications as a nuclear/radiological emergency responder.
• Serve rotating, on-call duty for approximately a third of the year, typically in one-week increments.
• Ability to deploy world-wide for exercises and responses, with as little as two-hour notice when on-call.
• Maintain training and ensure job-specific qualifications remain current; as well as attend onsite and off-site training as necessary to maintain competency.
• Assist in the development of company and emergency response guidelines, manuals, procedures, etc.
• Develop and implement corrective actions and lessons learned.
• Develop training materials and deliver trainings to emergency responders across the Department of Energy community.
• Assist with the preparation of technical reports and recommendations.
• Organize, evaluate, and interpret data by comparison against standards and guidelines.
• Plan and conduct work requiring judgment in the evaluation, selection, application, adaptation, and modification of standard techniques, guidelines, procedures, and criteria.
• Be able to present analysis results to a technical or non-technical audience.
• Conduct testing and evaluation of radiation detection equipment and acquisition/analysis software.
• Provide expertise, feedback, and input into the development of improved radiation detection systems and analysis algorithms.
• Provide scientific guidance on projects involving an interdisciplinary team of engineers, physicists, and technicians.
• Operate radiation detection equipment in field operations.
• Maintain subject matter expertise and proficiency on radiation detection equipment to instruct during courses, or offer troubleshooting during operations or events.
• Develop and design scientific and technical content for training exercises.
• Coordinate assigned work with other personnel as directed.
• Provide direction of specific activities as assigned.
• Perform other duties as assigned by supervisor/manager.
• In addition to fulfilling basic ESH&Q obligations:
  •Must address all aspects of safety in design and execution of work.
  •Work may affect public health and safety.
  •Likely to act as a safety team lead.
  •May help formulate ESH&Q protocols.

Qualifications

Due to the nature of our work, US Citizenship is required for all positions.

• Bachelor's degree in calculus-based (STEM) field, plus at 9 years' relevant experience. Skill building experience must demonstrate either deeper technical specialization or additional cross-disciplinary knowledge. Graduate research experience may be recognized.
• Membership in professional organizations may be required, depending on position requirements.
• Experience with one or more of the following is highly desired: gamma-ray spectroscopy, operational health physics, and customer service and/or training development and delivery.
• Must possess expertise or experience related to stochastic and deterministic radiation transport modeling.
• Must have strong written and oral communications skills and must show a demonstrated ability to work on complex applied projects in a group atmosphere.
• Must have the ability to interface effectively with technical personnel from other MSTS organizations, outside organizations, and government agencies.
• Must be willing and able to perform work during non-standard hours, take on-call duty, and deploy worldwide on short notice.
• Must be able to perform critical job functions during high stress situations or in environments during real world deployments.
• Must be able to meet Company requirements for worldwide travel that includes a physical and immunizations.
• Ability to work independently or in a team environment on a wide variety of tasks.
• Working knowledge of Office365, Word, Excel, Adobe Acrobat, and Outlook is required.
• Must be fitted for and qualify for use with various respiratory protection and personal protective equipment.
• Must be able to lift 50 lbs.
• Must be able to obtain and maintain a Department of Energy (DOE) Q Clearance and Sensitive Compartmented Information access (position will be cleared to this level).
• Must be able to participate in National Response Asset Deployment activities, including flights onboard government aircraft for missions and deployments.
• The primary work location will be at the Remote Sensing Laboratory on Joint Base Andrews in Maryland.
• Work schedules include: 5/8s (Monday through Friday), 4/10s (Monday through Thursday), and 9/80s (with every other Friday off). Work schedules are subject to change and are at the discretion of management.
• Pre-placement physical examination, which includes a drug screen, is required. MSTS maintains a substance abuse policy that includes random drug testing.
• Must possess a valid driver's license.

MSTS is required by DOE directive to conduct a pre-employment drug test and background review that includes checks of personal references, credit, law enforcement records, and employment/education verifications. Applicants offered employment with MSTS are also subject to a federal background investigation to meet the requirements for access to classified information or matter if the duties of the position require a DOE security clearance. Substance abuse or illegal drug use, falsification of information, criminal activity, serious misconduct or other indicators of untrustworthiness can cause a clearance to be denied or terminated by DOE, resulting in the inability to perform the duties assigned and subsequent termination of employment. In addition, Applicants for employment must be able to obtain and maintain a DOE Q-level security clearance, which requires U.S. citizenship, at least 18 years of age. Reference DOE Order 472.2, "Personnel Security". If you hold more than one citizenship (i.e., of the U.S. and another country), your ability to obtain a security clearance may be impacted.

Department of Energy Q Clearance and Secret Compartmented Information access (position will be cleared to this level). Reviews and tests for the absence of any illegal drug as defined in 10 CFR Part 707.4, "Workplace Substance Abuse Programs at DOE Sites," will be conducted. Applicant selected will be subject to a Federal background investigation, required to participate in subsequent reinvestigations, and must meet the eligibility requirements for access to classified matter. Successful completion of a counterintelligence evaluation, which may include a counterintelligence-scope polygraph examination, may also be required. Reference 10 CFR Part 709, "Counterintelligence Evaluation Program."

MSTS is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, national origin, disability, veteran status or other characteristics protected by law. MSTS is a background screening, drug-free workplace.

Annual salary range for this position is: $119,246.40 - $181,854.40.

Starting salary is determined based on the position market value, the individual candidate education and experience and internal equity.

**General Description:**
We are seeking a Clinical Biomarker Scientist to lead biomarker strategy and execution in clinical studies. The role involves designing and analyzing biomarker studies, collaborating with cross-functional teams, and managing external CROs to ensure high-quality data delivery. The ideal candidate will have a strong background in translational research, a deep understanding of clinical biomarkers, and excellent communication skills to drive insights that support clinical decision making and advance drug development.
**Essential Functions of the job:**
+ Serve as the primary biomarker scientist for the clinical study team, ensuring biomarker strategies are integrated into clinical development plans.
+ Deliver robust biomarker strategies at the study level, including target engagement, pharmacodynamics endpoints, patient selection and companion diagnostic development (if appropriate).
+ Align biomarker strategies with clinical operational plans and functional area capabilities to ensure seamless execution.
+ Author and edit biomarker sections of clinical protocols, ensuring scientific accuracy and clarity.
+ Oversee the implementation of biomarker plans, including sample collection, alignment with consent forms, Human Biological Sample Management, and adherence to protocol and data standards.
+ Collaborate with and manage external vendors and collaborators involved in clinical studies or translational research, including vendor evaluation and selection for biomarker activities.
+ Evaluate and integrate emerging technologies into clinical studies, working closely with statisticians, bioinformatics teams, clinical and translational groups to address biomarker needs.
+ Lead the analysis and summarization of study specific biomarker data, presenting findings and strategic recommendations to internal and external stakeholders.
+ Stay informed on emerging scientific and technological advancement, contributing to the group's continuous improvement and innovation.
**Qualifications:**
+ 3+ years of experience with PhD in Life Science (e.g., Immunology, Molecular & Cellular Biology, Biochemistry, or related fields), with a strong emphasis on immunology research and its application to translational science.
+ Demonstrated experience in clinical biomarkers and translational research in a pharmaceutical or biotech industry, particularly in Immunology, Oncology, or hematology.
+ Deep understanding of immunological mechanisms, immune-related biomarkers, and their role in clinical drug development.
+ Familiarity with the operational aspects of implementing biomarker strategies in clinical development is highly desirable.
+ Proven ability to collaborate within cross-functional, international teams and thrive in a fast-paced dynamic environment.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

**Job Description**
Mission Support and Test Services, LLC (MSTS) manages and operates the Nevada National Security Site (NNSS) for the U.S. National Nuclear Security Administration (NNSA). Our MISSION is to help ensure the security of the United States and its allies by providing high-hazard experimentation and incident response capabilities through operations, engineering, education, field, and integration services and by acting as environmental stewards to the Site's Cold War legacy. Our VISION is to be the user site of choice for large-scale, high-hazard, national security experimentation, with premier facilities and capabilities below ground, on the ground, and in the air. (See NNSS.gov for our unique capabilities.) Our 2,750+ professional, craft, and support employees are called upon to innovate, collaborate, and deliver on some of the more difficult nuclear security challenges facing the world today.
+ MSTS offers our full-time employees highly competitive salaries and benefits packages including medical, dental, and vision; both a pension and a 401k; paid time off and 96 hours of paid holidays; relocation (if located more than 75 miles from work location); tuition assistance and reimbursement; and more.
+ MSTS is a limited liability company consisting of Honeywell International Inc. (Honeywell), Jacobs Engineering Group Inc. (Jacobs), and HII Nuclear Inc.
**Responsiblities**
The Remote Sensing Laboratory - located on Nellis Air Force Base in Nevada - is searching for an enthusiastic and energetic individual looking to join our dynamic emergency response organization that is responsible for supporting several national-level radiological and nuclear emergency response assets. For more information on the work done at the Remote Sensing Laboratory in support of a very important mission please check out this video . The selected candidate will be expected to:
**Key Responsibilities**
+ Collect and analyze radiological data from a variety of platforms, and advise public safety officials on the consequences of a radiological incident.
+ Utilize specialized tools and applications to calculate potential impacts to the public, workers, and the environment to support radiological emergencies.
+ Attain and maintain qualification as an emergency responder.
+ Serve rotating, on-call duty for approximately a third of the year, typically in one-week increments.
+ Ability to deploy world-wide for exercises and responses, with as little as two-hour notice when on-call.
+ Maintain training and ensure job-specific qualifications remain current; as well as attend onsite and off-site training as necessary to maintain competency.
+ Assist in the development of company and emergency response guidelines, manuals, procedures, etc.
+ Develop and implement corrective actions and lessons learned.
+ Develop training materials and deliver trainings to emergency responders across the DOE community.
+ Assist with the preparation of technical reports and recommendations.
+ Organize, evaluate, and interpret data by comparison against standards and guidelines.
+ Plan and conduct work requiring judgment in the evaluation, selection, application, adaptation, and modification of standard techniques, guidelines, procedures, and criteria.
+ Maintain the ability to present analysis results to a technical or non-technical audience.
+ Conduct test and evaluation of radiation detection equipment and acquisition/analysis software.
+ Provide expertise, feedback, and input into the development of improved radiation detection systems and analysis algorithms.
+ Provide scientific guidance on projects involving an interdisciplinary team of engineers, software developers, scientists, and technicians.
+ Operate radiation detection equipment in field operations.
+ Maintain subject matter expertise and proficiency on detection equipment to instruct during courses, or offer troubleshooting during operations or events.
+ Develop and design scientific and technical content for training exercises.
+ Coordinate assigned work with other personnel as directed.
+ Provide direction of specific activities as assigned.
+ Perform other duties as assigned by Supervisor/Manager.
**Qualifications**
+ Bachelor's degree in calculus-based (STEM) field, plus at 9 years' relevant experience. _Skill building experience must demonstrate either deeper technical specialization or additional cross-disciplinary knowledge. Graduate research experience may be recognized._
+ Ph.D is preferred.
+ Experience with one or more of the following is highly desired: gamma-ray spectroscopy, operational health physics, and customer service and/or training development and delivery.
+ Must possess expertise or experience related to stochastic and deterministic radiation transport modeling.
+ Must have strong written and oral communications skills and must show a demonstrated ability to work on complex applied projects in a group atmosphere.
+ Must have the ability to interface effectively with technical personnel from other MSTS organizations, outside organizations, and government agencies.
+ Must be willing and able to perform work during non-standard hours, take on-call duty, and deploy worldwide on short notice.
+ Must be able to perform critical job functions while under high stress environments such as those presented in real world deployments.
+ Must be able to meet Company requirements for worldwide travel including medical physical and immunizations.
+ Ability to work independently or in a team environment on a wide variety of tasks.
+ Working knowledge of Office365, Word, Excel, Adobe Acrobat, and Outlook is required.
+ Must be fitted for and qualify for use with various respiratory protection and personal protective equipment.
+ Must be able to lift 50 lbs.
+ Must be able to participate in National Response Asset Deployment activities, including flight onboard government aircraft for missions and deployments.
+ Candidate must be able to obtain SCI accesses.
+ The primary work location will be at the Remote Sensing Laboratory located on Nellis Air Force Base, Las Vegas, NV.
+ Work schedule will be 4/10s Monday through Thursday. (subject to change).
+ Pre-placement physical examination, which includes a drug screen, is required. MSTS maintains a substance abuse policy that includes random drug testing.
+ Must possess a valid driver's license.
MSTS is required by DOE directive to conduct a pre-employment drug test and background review that includes checks of personal references, credit, law enforcement records, and employment/education verifications. Applicants offered employment with MSTS are also subject to a federal background investigation to meet the requirements for access to classified information or matter if the duties of the position require a DOE security clearance. Substance abuse or illegal drug use, falsification of information, criminal activity, serious misconduct or other indicators of untrustworthiness can cause a clearance to be denied or terminated by DOE, resulting in the inability to perform the duties assigned and subsequent termination of employment. In addition, Applicants for employment must be able to obtain and maintain a DOE Q-level security clearance, which requires U.S. citizenship, at least 18 years of age. Reference DOE Order 472.2 ( , "Personnel Security". If you hold more than one citizenship (i.e., of the U.S. and another country), your ability to obtain a security clearance may be impacted.
**Department of Energy Q Clearance** (position will be cleared to this level). Reviews and tests for the absence of any illegal drug as defined in 10 CFR Part 707.4 ( , "Workplace Substance Abuse Programs at DOE Sites," will be conducted. Applicant selected will be subject to a Federal background investigation, required to participate in subsequent reinvestigations, and must meet the eligibility requirements for access to classified matter. Successful completion of a counterintelligence evaluation, which may include a counterintelligence-scope polygraph examination, may also be required. Reference 10 CFR Part 709 ( , "Counterintelligence Evaluation Program."
MSTS is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, national origin, disability, veteran status or other characteristics protected by law. MSTS is a background screening, drug-free workplace.
Annual salary range for this position is: **$119,246.40 - $181,854.40.**
Starting salary is determined based on the position market value, the individual candidate education and experience and internal equity.

**Job Description**
Mission Support and Test Services, LLC (MSTS) manages and operates the Nevada National Security Site (NNSS) for the U.S. National Nuclear Security Administration (NNSA). Our MISSION is to help ensure the security of the United States and its allies by providing high-hazard experimentation and incident response capabilities through operations, engineering, education, field, and integration services and by acting as environmental stewards to the Site's Cold War legacy. Our VISION is to be the user site of choice for large-scale, high-hazard, national security experimentation, with premier facilities and capabilities below ground, on the ground, and in the air. (See NNSS.gov for our unique capabilities.) Our 2,750+ professional, craft, and support employees are called upon to innovate, collaborate, and deliver on some of the more difficult nuclear security challenges facing the world today.
+ MSTS offers our full-time employees highly competitive salaries and benefits packages including medical, dental, and vision; both a pension and a 401k; paid time off and 96 hours of paid holidays; relocation (if located more than 75 miles from work location); tuition assistance and reimbursement; and more.
+ MSTS is a limited liability company consisting of Honeywell International Inc. (Honeywell), Jacobs Engineering Group Inc. (Jacobs), and HII Nuclear Inc.
**Responsiblities**
The Radiological Control Department is looking for an individual with a strong attention to detail to work as a Principal Scientist with extensive experience in the field of health physics. This Scientist will have the ability to balance responsibilities with multiple organizations. In this role as Scientist, you will have assignments that directly support MSTS and assignments that directly support the Joint Laboratory Operations Nevada (JLON) **.**
**Key Responsibilities**
+ Develop methods and techniques for acquiring, analyzing, and processing radiological data.
+ Prepare a variety of technical and non-technical reports, including procedures and plans.
+ Ensure compliance with federal, state, and local regulations, National Nuclear Security Administration (NNSA) orders, and corporate requirements.
+ Consult with supervisors and departmental representatives on radiological control matters to ensure work procedures are incompliance with the Tennant Organization's (MSTS, LLNL or LANL) core processes, and governmental requirements.
+ Serve as point of contact for assigned projects between Tennant Organizations (MSTS, LLNL and LANL).
+ Perform radiological engineering analyses and calculations using industry available software.
+ Encourage development and publishing in industry-standard journals.
+ Apply knowledge and ingenuity to implement cutting edge, pioneering solutions in the technical arena.
+ Attend staff meetings, and planning and scheduling meetings relevant to radiological controls and engineering issues.
+ Conduct management assessments.
+ Draft work packages and proposed test plans, review packages and plans to ensure necessary requirements are incorporated into work control.
+ Serve as Technical Lead for major projects and startups.
+ Serve as an expert advisor to other personnel and management on difficult and critical technical issues.
+ Complete special projects to meet internal and external customer expectations.
+ Perform other duties assigned by Management.
**Qualifications**
+ Bachelor's degree in a calculus-based (STEM) field, plus at least 9 years' relevant experience. _Skill building experience must demonstrate either deeper technical specialization or additional cross-disciplinary knowledge. Graduate research experience may be recognized._
+ Must have 6 years of experience as a health physicist as part of the 9 years' relevant overall experience. _Graduate and Doctoral education may be granted credit for some of the experience criteria._
+ Professional certification (Certified Health Physicist) is preferred. Willingness to achieve professional certification (if not already certified) is desired.
+ Demonstrated experience with operational health physics and engineering controls for purposes of mitigating radiological hazards is necessary.
+ Must possess effective oral and written communications skills and demonstrated ability to write technical reports.
+ Must possess planning/organizational skills and initiative.
+ Must be able to employ independent judgment and apply professional knowledge to ensure that assignments are completed efficiently, accurately, and on time.
+ Must possess interpersonal communication skills to deal with contacts in an effective, positive, and professional manner.
+ Must possess mathematical skill and ability to understand complex data, terminology, procedures, laws, and regulations.
+ Must have experience in software programs such as Adobe Acrobat, Microsoft Word, Excel, PowerPoint, and Outlook.
+ Work location is at the NNSS in Mercury, Nevada (65 miles northwest of Las Vegas), and forward Areas of the NNSS.
+ Schedule is designated as 4/10s (Mon-Thur). May be requested to perform on-call duty and must be able to work nonstandard hours.
+ Pre-placement physical examination, which includes a drug screen, is required. MSTS maintains a substance abuse policy that includes random drug testing.
+ Must possess a valid driver's license.
MSTS is required by DOE directive to conduct a pre-employment drug test and background review that includes checks of personal references, credit, law enforcement records, and employment/education verifications. Applicants offered employment with MSTS are also subject to a federal background investigation to meet the requirements for access to classified information or matter if the duties of the position require a DOE security clearance. Substance abuse or illegal drug use, falsification of information, criminal activity, serious misconduct or other indicators of untrustworthiness can cause a clearance to be denied or terminated by DOE, resulting in the inability to perform the duties assigned and subsequent termination of employment. In addition, Applicants for employment must be able to obtain and maintain a DOE Q-level security clearance, which requires U.S. citizenship, at least 18 years of age. Reference DOE Order 472.2 ( , "Personnel Security". If you hold more than one citizenship (i.e., of the U.S. and another country), your ability to obtain a security clearance may be impacted.
**Department of Energy Q Clearance** (position will be cleared to this level). Reviews and tests for the absence of any illegal drug as defined in 10 CFR Part 707.4 ( , "Workplace Substance Abuse Programs at DOE Sites," will be conducted. Applicant selected will be subject to a Federal background investigation, required to participate in subsequent reinvestigations, and must meet the eligibility requirements for access to classified matter. Successful completion of a counterintelligence evaluation, which may include a counterintelligence-scope polygraph examination, may also be required. Reference 10 CFR Part 709 ( , "Counterintelligence Evaluation Program."
MSTS is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, national origin, disability, veteran status or other characteristics protected by law. MSTS is a background screening, drug-free workplace.
Annual salary range for this position is: **$119,246.40 - $181,854.40.**
Starting salary is determined based on the position market value, the individual candidate education and experience and internal equity.

Join Amgen's Mission of Serving Patients
At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.
Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Principal Scientist
**What you will do**
Let's do this. Let's change the world. In this vital role you will apply your knowledge and skills to perform analytical development of late-stage biological therapeutics. In your daily work you will:
+ Interface and collaborate with other functional areas in matrix environment, serving as analytical subject matter expert to support and advise design of characterization studies, data analysis and investigations.
+ Provide analytical testing support to functions including but not limited to Drug Substance Technologies, Quality, and Manufacturing
+ Leverage latest advances in protein analytics to develop, optimize, troubleshoot, remediate, qualify, validate and transfer analytical methods
+ Design and execute analytical studies to support process and product characterization for late stage development products utilizing protein chemistry, separation sciences and mass spectrometry
+ Interpret results, author technical protocols, reports, analytical method descriptions and analytical CMC sections in regulatory documents
+ Lead project teams and/or project sub-teams to meet program goals
+ Provide expertise and evaluation of Amgen's platform and analytical technologies, helping to drive innovation and efficiency within Process Development.
**What we expect of you**
We are all different, yet we all use our unique contributions to serve patients. The Scientific professional we seek is a leader with these qualifications.
**Basic Qualifications:**
+ Bachelor's degree and 7 years of Scientific experience; Or
+ Master's degree and 5 years of Scientific experience; Or
+ Doctorate degree PhD OR PharmD OR MD and 2 years of Scientific experience
**Preferred Qualifications:**
+ Advanced degree in Analytical Chemistry or related area with extensive experience performing independent scientific research
+ Four or more years of experience in pharmaceutical process development with related experience in analytical support, execution of methods, and investigational testing.
+ Strong and in-depth expertise in multiple analytical techniques (i.e., SE-HPLC, RP-HPLC, CE, LC-MS); characterization of protein modifications with glycan mapping and peptide mapping.
+ Experience in method transfers, method validation, method troubleshooting, and complex investigations.
+ Familiarity with and understanding of United States Pharmacopeia (USP) monographs and chapters, and International Conference on Harmonization (ICH) / Food & Drug Administration (FDA) mentorship documents related to analytical method transfer and validation.
+ Experience in authoring and review of regulatory submission product quality sections and supporting documentation. Experience preparing for and responding to RTQ, including assessment of CQAs, product quality targets and attribute risk assessment.
+ Strong oral and verbal communication skills, ability to interact effectively with diverse internal and external stakeholders.
+ Proficiency in solving complex problems, ability to work independently, proactively seek outside resources and collaborate, ability to multitask, effectively plan and follow through on complex projects.
+ A self-starter with strong decision-making skills, who thrives in collaborative matrix environment and can provide cross-functional leadership and mentorship to junior staff.
**What you can expect of us**
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
+ A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
+ A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
+ Stock-based long-term incentives
+ Award-winning time-off plans
+ Flexible work models, including remote and hybrid work arrangements, where possible
Apply now and make a lasting impact with the Amgen team.
**careers.amgen.com**
In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadline
Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

**Job Description**
Mission Support and Test Services, LLC (MSTS) manages and operates the Nevada National Security Site (NNSS) for the U.S. National Nuclear Security Administration (NNSA). Our MISSION is to help ensure the security of the United States and its allies by providing high-hazard experimentation and incident response capabilities through operations, engineering, education, field, and integration services and by acting as environmental stewards to the Site's Cold War legacy. Our VISION is to be the user site of choice for large-scale, high-hazard, national security experimentation, with premier facilities and capabilities below ground, on the ground, and in the air. (See NNSS.gov for our unique capabilities.) Our 2,750+ professional, craft, and support employees are called upon to innovate, collaborate, and deliver on some of the more difficult nuclear security challenges facing the world today.
+ MSTS offers our full-time employees highly competitive salaries and benefits packages including medical, dental, and vision; both a pension and a 401k; paid time off and 96 hours of paid holidays; relocation (if located more than 75 miles from work location); tuition assistance and reimbursement; and more.
+ MSTS is a limited liability company consisting of Honeywell International Inc. (Honeywell), Jacobs Engineering Group Inc. (Jacobs), and HII Nuclear Inc.
**Responsiblities**
The Remote Sensing Laboratory, located on Joint Base Andrews in Maryland, is searching for an enthusiastic and energetic individual looking to join our dynamic emergency response organization that is responsible for supporting several national-level emergency response assets. The selected candidate will be expected to:
**Key Responsibilities**
+ Collect and analyze radiological data from a variety of platforms, and advise public safety officials on the consequences of a radiological incident.
+ Utilize specialized tools and applications to calculate potential impact to the public, workers, and the environment to support radiological emergencies.
+ Attain and maintain qualifications as a nuclear/radiological emergency responder.
+ Serve rotating, on-call duty for approximately a third of the year, typically in one-week increments.
+ Ability to deploy world-wide for exercises and responses, with as little as two-hour notice when on-call.
+ Maintain training and ensure job-specific qualifications remain current; as well as attend onsite and off-site training as necessary to maintain competency.
+ Assist in the development of company and emergency response guidelines, manuals, procedures, etc.
+ Develop and implement corrective actions and lessons learned.
+ Develop training materials and deliver trainings to emergency responders across the Department of Energy community.
+ Assist with the preparation of technical reports and recommendations.
+ Organize, evaluate, and interpret data by comparison against standards and guidelines.
+ Plan and conduct work requiring judgment in the evaluation, selection, application, adaptation, and modification of standard techniques, guidelines, procedures, and criteria.
+ Be able to present analysis results to a technical or non-technical audience.
+ Conduct testing and evaluation of radiation detection equipment and acquisition/analysis software.
+ Provide expertise, feedback, and input into the development of improved radiation detection systems and analysis algorithms.
+ Provide scientific guidance on projects involving an interdisciplinary team of engineers, physicists, and technicians.
+ Operate radiation detection equipment in field operations.
+ Maintain subject matter expertise and proficiency on radiation detection equipment to instruct during courses, or offer troubleshooting during operations or events.
+ Develop and design scientific and technical content for training exercises.
+ Coordinate assigned work with other personnel as directed.
+ Provide direction of specific activities as assigned.
+ Perform other duties as assigned by supervisor/manager.
+ In addition to fulfilling basic ESH&Q obligations:- Must address all aspects of safety in design and execution of work.- Work may affect public health and safety.- Likely to act as a safety team lead.- May help formulate ESH&Q protocols.
**Qualifications**
**Due to the nature of our work, US Citizenship is required for all positions.**
+ Bachelor's degree in calculus-based (STEM) field, plus at 9 years' relevant experience. _Skill building experience must demonstrate either deeper technical specialization or additional cross-disciplinary knowledge. Graduate research experience may be recognized._
+ Membership in professional organizations may be required, depending on position requirements.
+ Experience with one or more of the following is highly desired: gamma-ray spectroscopy, operational health physics, and customer service and/or training development and delivery.
+ Must possess expertise or experience related to stochastic and deterministic radiation transport modeling.
+ Must have strong written and oral communications skills and must show a demonstrated ability to work on complex applied projects in a group atmosphere.
+ Must have the ability to interface effectively with technical personnel from other MSTS organizations, outside organizations, and government agencies.
+ Must be willing and able to perform work during non-standard hours, take on-call duty, and deploy worldwide on short notice.
+ Must be able to perform critical job functions during high stress situations or in environments during real world deployments.
+ Must be able to meet Company requirements for worldwide travel that includes a physical and immunizations.
+ Ability to work independently or in a team environment on a wide variety of tasks.
+ Working knowledge of Office365, Word, Excel, Adobe Acrobat, and Outlook is required.
+ Must be fitted for and qualify for use with various respiratory protection and personal protective equipment.
+ Must be able to lift 50 lbs.
+ Must be able to obtain and maintain a Department of Energy (DOE) Q Clearance and Sensitive Compartmented Information access (position will be cleared to this level).
+ Must be able to participate in National Response Asset Deployment activities, including flights onboard government aircraft for missions and deployments.
+ The primary work location will be at the Remote Sensing Laboratory on Joint Base Andrews in Maryland.
+ Work schedules include: 5/8s (Monday through Friday), 4/10s (Monday through Thursday), and 9/80s (with every other Friday off). Work schedules are subject to change and are at the discretion of management.
+ Pre-placement physical examination, which includes a drug screen, is required. MSTS maintains a substance abuse policy that includes random drug testing.
+ Must possess a valid driver's license.
MSTS is required by DOE directive to conduct a pre-employment drug test and background review that includes checks of personal references, credit, law enforcement records, and employment/education verifications. Applicants offered employment with MSTS are also subject to a federal background investigation to meet the requirements for access to classified information or matter if the duties of the position require a DOE security clearance. Substance abuse or illegal drug use, falsification of information, criminal activity, serious misconduct or other indicators of untrustworthiness can cause a clearance to be denied or terminated by DOE, resulting in the inability to perform the duties assigned and subsequent termination of employment. In addition, Applicants for employment must be able to obtain and maintain a DOE Q-level security clearance, which requires U.S. citizenship, at least 18 years of age. Reference DOE Order 472.2 ( , "Personnel Security". If you hold more than one citizenship (i.e., of the U.S. and another country), your ability to obtain a security clearance may be impacted.
**Department of Energy Q Clearance and Secret Compartmented Information access** (position will be cleared to this level). Reviews and tests for the absence of any illegal drug as defined in 10 CFR Part 707.4 ( , "Workplace Substance Abuse Programs at DOE Sites," will be conducted. Applicant selected will be subject to a Federal background investigation, required to participate in subsequent reinvestigations, and must meet the eligibility requirements for access to classified matter. Successful completion of a counterintelligence evaluation, which may include a counterintelligence-scope polygraph examination, may also be required. Reference 10 CFR Part 709 ( , "Counterintelligence Evaluation Program."
MSTS is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, national origin, disability, veteran status or other characteristics protected by law. MSTS is a background screening, drug-free workplace.
Annual salary range for this position is: $119,246.40 - $181,854.40.
Starting salary is determined based on the position market value, the individual candidate education and experience and internal equity.

About Xaira Therapeutics

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

About the Role

We are seeking a strategic and hands-on Senior Principal Scientist, Computational Biology to join our Computational Biology department within the Biology and Drug Discovery organization. This critical role as an individual contributor and peer mentor will advance our genomics and proteomics initiatives relating to mechanism of action studies for early programs and identification of biomarkers and patient subgroups for translational development. Communication with a wide variety of wet lab and dry lab scientists is critical. The ideal candidate brings deep expertise in computational biology, translational informatics, and biomarkers, along with a strong record of cross-functional project leadership in pharma or biotech. You must be available to work on-site in South San Francisco.
Key Responsibilities

• Pre-clinical Omics Analysis: Guide the decision-making, design and execution of multi-omics studies (e.g., transcriptomics, proteomics) in pre-clinical in vitro and in vivo models to identify novel targets, understand mechanisms of action, and support lead optimization.
• Translational Informatics: Perform the analysis and integration of multi-modal clinical, molecular, and real-world molecular data to drive insights across the drug development lifecycle, including patient stratification, indication selection, and biomarker discovery.
• Cross-Functional Collaboration: Serve as a key partner to translational medicine scientists, clinical development teams, biostatisticians, and external collaborators. Provide expert guidance in aligning scientific and business strategy with program objectives.
• Scientific Communication: Effectively communicate translational insights to diverse audiences, including internal and external teams.
• Project Leadership: Mentor fellow computational biology scientists in using RNA-seq (bulk and single cell) and proteomics to advance programs in the early pipeline; contribute to hiring, resource planning, and talent development. Foster a culture of scientific excellence and innovation.

Qualifications

• Education: PhD in Computational Biology, Bioinformatics, Biostatistics, Genomics, or related field.
• Experience: 10+ years of industry experience in pharma, biotech, or related organizations, including substantial post-PhD individual contributor and strategic computational biology work in preclinical, translational informatics.
• Technical Expertise:
• Advanced experience in design and analysis of multi-omics (genomics, transcriptomics, proteomics), clinical trial, and real-world molecular data datasets.
• Proven track record with biomarker discovery, patient stratification, and clinical decision support
• Proficiency in advanced computational/statistical methods (e.g., machine learning, statistical modeling) and familiarity with clinical assay technologies.
• Many years of experience with R, python, git, docker and cloud computing platforms
• Translational Experience: Demonstrated success contributing to regulatory filings and guiding biomarker strategy for early clinical programs.
• Collaboration & Communication: Excellent interpersonal skills, with a history of impactful collaboration across disciplines and effective communication of complex scientific concepts to varied audiences.
• Innovation Mindset: Passion for leveraging emerging technologies (e.g., explainable AI/ML, single-cell analysis) to solve key translational challenges and improve patient outcomes.

Compensation

Annual

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $170,000 - $225,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. XairaTherapeutics is not responsible for any fees related to unsolicited resumes.