11,604 Principal Scientist jobs in the United States

Join Amgen's Mission of Serving Patients
At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.
Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Principal Scientist
**What you will do**
Let's do this. Let's change the world. In this vital role you will apply your knowledge and skills to perform analytical development of late-stage biological therapeutics. In your daily work you will:
+ Interface and collaborate with other functional areas in matrix environment, serving as analytical subject matter expert to support and advise design of characterization studies, data analysis and investigations.
+ Provide analytical testing support to functions including but not limited to Drug Substance Technologies, Quality, and Manufacturing
+ Leverage latest advances in protein analytics to develop, optimize, troubleshoot, remediate, qualify, validate and transfer analytical methods
+ Design and execute analytical studies to support process and product characterization for late stage development products utilizing protein chemistry, separation sciences and mass spectrometry
+ Interpret results, author technical protocols, reports, analytical method descriptions and analytical CMC sections in regulatory documents
+ Lead project teams and/or project sub-teams to meet program goals
+ Provide expertise and evaluation of Amgen's platform and analytical technologies, helping to drive innovation and efficiency within Process Development.
**What we expect of you**
We are all different, yet we all use our unique contributions to serve patients. The Scientific professional we seek is a leader with these qualifications.
**Basic Qualifications:**
+ Bachelor's degree and 7 years of Scientific experience; Or
+ Master's degree and 5 years of Scientific experience; Or
+ Doctorate degree PhD OR PharmD OR MD and 2 years of Scientific experience
**Preferred Qualifications:**
+ Advanced degree in Analytical Chemistry or related area with extensive experience performing independent scientific research
+ Four or more years of experience in pharmaceutical process development with related experience in analytical support, execution of methods, and investigational testing.
+ Strong and in-depth expertise in multiple analytical techniques (i.e., SE-HPLC, RP-HPLC, CE, LC-MS); characterization of protein modifications with glycan mapping and peptide mapping.
+ Experience in method transfers, method validation, method troubleshooting, and complex investigations.
+ Familiarity with and understanding of United States Pharmacopeia (USP) monographs and chapters, and International Conference on Harmonization (ICH) / Food & Drug Administration (FDA) mentorship documents related to analytical method transfer and validation.
+ Experience in authoring and review of regulatory submission product quality sections and supporting documentation. Experience preparing for and responding to RTQ, including assessment of CQAs, product quality targets and attribute risk assessment.
+ Strong oral and verbal communication skills, ability to interact effectively with diverse internal and external stakeholders.
+ Proficiency in solving complex problems, ability to work independently, proactively seek outside resources and collaborate, ability to multitask, effectively plan and follow through on complex projects.
+ A self-starter with strong decision-making skills, who thrives in collaborative matrix environment and can provide cross-functional leadership and mentorship to junior staff.
**What you can expect of us**
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
+ A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
+ A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
+ Stock-based long-term incentives
+ Award-winning time-off plans
+ Flexible work models, including remote and hybrid work arrangements, where possible
Apply now and make a lasting impact with the Amgen team.
**careers.amgen.com**
In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadline
Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

**Working with Us**
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible. When you join BMS, you are joining a diverse, high-achieving team united by a common mission. Within the Pharmaceutical Candidate Optimization (PCO) organization at BMS, the Development DMPK Team provides ADME (absorption, distribution, metabolism, and excretion) and PK (pharmacokinetics) support for all pipeline assets throughout clinical development, from candidate nomination through registration and lifecycle management. The Development DMPK team is responsible for characterizing the ADME properties, and drug-interaction potential of drug candidates. Working closely with drug safety and clinical pharmacology, Development DMPK plays a critical role in IND submissions and marketing
authorization applications. We utilize our deep expertise in ADME and PK to collaborate with peer R&D functions to identify and solve issues, enable clinical development and successful marketing authorizations across the globe.
PCO is looking for a Principal Scientist, Biotransformation to lead biotransformation activities in Development DMPK group that is an expert in ADME, DDI and drug development of all modalities including small molecules, protein therapeutics and novel modalities. The successful candidate will be the subject matter expert and provide strategy/guidance to project teams for advancement of candidate compounds. This job role will focus on hands-on metabolite profiling and characterization of drug candidates in vitro and in vivo to understand metabolic pathways to support drug discovery and development. More broadly, the scientist is expected to integrate this information with absorption, distribution and excretion data for candidate compounds for a full understanding of their drug metabolism and pharmacokinetic (PK) behavior. This role will be based in our R&D headquarters in Lawrenceville, NJ.
Key Responsibilities
+ Hands-on biotransformation studies within the Development DMPK group in support of project and portfolio progression.
+ Independently design, conduct, troubleshoot and provide oversight of cold and radiolabeled in vitro and in vivo preclinical and clinical biotransformation studies for small molecules and new modalities (i.e. peptides, ADCs).
+ Serve as a biotransformation subject matter expert in dynamic cross-functional team settings, to define strategies to achieve target product profiles, and to integrate in vitro and in vivo data for presentations.
+ Evaluate and implement innovative technologies and aid in developing strategies to evolve biotransformation capabilities and contribute to science through conference presentations and publication of new findings.
Basic Qualifications:
Bachelor's Degree with 8+ years of academic and / or industry experience
OR
Master's Degree with 6+ years of academic and / or industry experience
OR
PhD or equivalent advanced degree in the Life Sciences with 4+ years of academic and / or
industry experience.
Preferred Qualifications:
+ A highly motivated individual with 4+ years of post-doctoral and/or industry experience directly related to the Key Responsibilities listed above (hands-on experience and in-depth knowledge of biotransformation and disposition).
+ A significant advantage would be hands-on experience in application of the high-resolution mass spectrometry (HRMS) and NMR in cold in vivo metabolism studies including FIH, and strategies in 14C human ADME studies.
+ Understanding of regulatory requirements in the areas of drug metabolism, drug-drug interactions, bioanalysis, toxicology, and clinical pharmacology
+ Demonstrates excellent scientific verbal and technical communication, and interpersonal skills. Must be organized, pay attention to details and have strong organizational and planning skills.
+ Expertise and experience in one or more of the following areas:
+ Experience in drug development, authoring drug metabolism reports for regulatory submissions.
+ In-depth understanding of the principles, theories and approaches of biotransformation, drug disposition and drug interactions. Proven application of related techniques for qualitative and quantitative analysis of metabolites using HRMS and NMR.
+ Proven track of scientific leadership and publications.
+ Supervisory Organization PCO Dev-DMPK
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
**Compensation Overview:**
Princeton - NJ - US: $134,900 - $163,461
The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.
Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.
**Uniquely Interesting Work, Life-changing Careers**
With a single vision as inspiring as Transforming patients' lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
**On-site Protocol**
BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit careers.bms.com/ ( eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
**Company:** Bristol-Myers Squibb
**Req Number:** R
**Updated:** :05:55.838 UTC
**Location:** Princeton-NJ
Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

Principal Scientist- Full Time- Onsite; Whitesboro, New York
ICON plc is a world-leading healthcare intelligence and clinical research organization. We're proud to foster an inclusive environment driving innovation and excellence, and we welcome you to join us on our mission to shape the future of clinical development.
We are currently seeking a full-time **Principal Scientist** to join our diverse and dynamic team in Whitesboro, New York.
**What You Will Do:**
- Recognize, exemplify and adhere to ICON's values which centers around our commitment to People, Clients and Performance.
- As a member of staff, the employee is expected to embrace and contribute to our culture of process improvement with a focus on streamlining our processes adding value to our business and meeting client needs.
- Travel (approximately 5%) domestic and/or international
- Provide status updates of work in progress and estimate time needed for various tasks.
- Build and great relationships with department members and clients to ensure optimal service and deliverables.
- Identify issues and/or problems as appropriate, and propose and help implement workable solutions.
- Work with the Project Manager to prepare timelines for all procedures/tasks/goals and their completion dates.
- Attend team meetings as appropriate.
- Prepare scientific publications to support endeavors in new science, and attend seminars and workshops to expand professional capabilities.
- Interpret and summarize study results.
- Interact with clients to transmit study status and results.
- Assist in the definition and optimization of work processes.
- Undertake other reasonably related duties as may be assigned from time to time.
**Preferred Qualifications:**
+ 5+ years of bench level work/experience in LCMS department
+ Prior experience with LCMSMS (Sciex)
+ Skyline and in-silico, and other protein sequencing software
+ PhD preferred
+ Background in Chemistry, Biochemistry, etc. or degree in similar field
#LI-Onsite
#LI-HP1
**What ICON can offer you:**
Our success depends on the quality of our people. That's why we've made it a priority to build a diverse culture that rewards high performance and nurtures talent.
In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.
Our benefits examples include:
+ Various annual leave entitlements
+ A range of health insurance offerings to suit you and your family's needs.
+ Competitive retirement planning offerings to maximize savings and plan with confidence for the years ahead.
+ Global Employee Assistance Programme, LifeWorks, offering 24-hour access to a global network of over 80,000 independent specialized professionals who are there to support you and your family's well-being.
+ Life assurance
+ Flexible country-specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidized travel passes, health assessments, among others.
Visit our careers site ( to read more about the benefits ICON offers.
At ICON, inclusion & belonging are fundamental to our culture and values. We're dedicated to providing an inclusive and accessible environment for all candidates. ICON is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.
If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know or submit a request here ( in the role, but unsure if you meet all of the requirements? We would encourage you to apply regardless - there's every chance you're exactly what we're looking for here at ICON whether it is for this or other roles.
Salary range: $75,480.00-$94,350.00
Bonus, Com, Stock, Benefits & Disclaimer verbiage:
Actual compensation will be determined based on factors such as geographic location, work experience, education/training, and skill level. You may be eligible for a bonus, stock compensation and commissions in some cases depending on your role and performance.
Are you a current ICON Employee? Please click here ( to apply

**Job Description**
Mission Support and Test Services, LLC (MSTS) manages and operates the Nevada National Security Site (NNSS) for the U.S. National Nuclear Security Administration (NNSA). Our MISSION is to help ensure the security of the United States and its allies by providing high-hazard experimentation and incident response capabilities through operations, engineering, education, field, and integration services and by acting as environmental stewards to the Site's Cold War legacy. Our VISION is to be the user site of choice for large-scale, high-hazard, national security experimentation, with premier facilities and capabilities below ground, on the ground, and in the air. (See NNSS.gov for our unique capabilities.) Our 2,750+ professional, craft, and support employees are called upon to innovate, collaborate, and deliver on some of the more difficult nuclear security challenges facing the world today.
+ MSTS offers our full-time employees highly competitive salaries and benefits packages including medical, dental, and vision; both a pension and a 401k; paid time off and 96 hours of paid holidays; relocation (if located more than 75 miles from work location); tuition assistance and reimbursement; and more.
+ MSTS is a limited liability company consisting of Honeywell International Inc. (Honeywell), Jacobs Engineering Group Inc. (Jacobs), and HII Nuclear Inc.
**Responsiblities**
The Remote Sensing Laboratory - located on Nellis Air Force Base in Nevada - is searching for an enthusiastic and energetic individual looking to join our dynamic emergency response organization that is responsible for supporting several national-level radiological and nuclear emergency response assets. For more information on the work done at the Remote Sensing Laboratory in support of a very important mission please check out this video . The selected candidate will be expected to:
**Key Responsibilities**
+ Collect and analyze radiological data from a variety of platforms, and advise public safety officials on the consequences of a radiological incident.
+ Utilize specialized tools and applications to calculate potential impacts to the public, workers, and the environment to support radiological emergencies.
+ Attain and maintain qualification as an emergency responder.
+ Serve rotating, on-call duty for approximately a third of the year, typically in one-week increments.
+ Ability to deploy world-wide for exercises and responses, with as little as two-hour notice when on-call.
+ Maintain training and ensure job-specific qualifications remain current; as well as attend onsite and off-site training as necessary to maintain competency.
+ Assist in the development of company and emergency response guidelines, manuals, procedures, etc.
+ Develop and implement corrective actions and lessons learned.
+ Develop training materials and deliver trainings to emergency responders across the DOE community.
+ Assist with the preparation of technical reports and recommendations.
+ Organize, evaluate, and interpret data by comparison against standards and guidelines.
+ Plan and conduct work requiring judgment in the evaluation, selection, application, adaptation, and modification of standard techniques, guidelines, procedures, and criteria.
+ Maintain the ability to present analysis results to a technical or non-technical audience.
+ Conduct test and evaluation of radiation detection equipment and acquisition/analysis software.
+ Provide expertise, feedback, and input into the development of improved radiation detection systems and analysis algorithms.
+ Provide scientific guidance on projects involving an interdisciplinary team of engineers, software developers, scientists, and technicians.
+ Operate radiation detection equipment in field operations.
+ Maintain subject matter expertise and proficiency on detection equipment to instruct during courses, or offer troubleshooting during operations or events.
+ Develop and design scientific and technical content for training exercises.
+ Coordinate assigned work with other personnel as directed.
+ Provide direction of specific activities as assigned.
+ Perform other duties as assigned by Supervisor/Manager.
**Qualifications**
+ Bachelor's degree in calculus-based (STEM) field, plus at 9 years' relevant experience. _Skill building experience must demonstrate either deeper technical specialization or additional cross-disciplinary knowledge. Graduate research experience may be recognized._
+ Ph.D is preferred.
+ Experience with one or more of the following is highly desired: gamma-ray spectroscopy, operational health physics, and customer service and/or training development and delivery.
+ Must possess expertise or experience related to stochastic and deterministic radiation transport modeling.
+ Must have strong written and oral communications skills and must show a demonstrated ability to work on complex applied projects in a group atmosphere.
+ Must have the ability to interface effectively with technical personnel from other MSTS organizations, outside organizations, and government agencies.
+ Must be willing and able to perform work during non-standard hours, take on-call duty, and deploy worldwide on short notice.
+ Must be able to perform critical job functions while under high stress environments such as those presented in real world deployments.
+ Must be able to meet Company requirements for worldwide travel including medical physical and immunizations.
+ Ability to work independently or in a team environment on a wide variety of tasks.
+ Working knowledge of Office365, Word, Excel, Adobe Acrobat, and Outlook is required.
+ Must be fitted for and qualify for use with various respiratory protection and personal protective equipment.
+ Must be able to lift 50 lbs.
+ Must be able to participate in National Response Asset Deployment activities, including flight onboard government aircraft for missions and deployments.
+ Candidate must be able to obtain SCI accesses.
+ The primary work location will be at the Remote Sensing Laboratory located on Nellis Air Force Base, Las Vegas, NV.
+ Work schedule will be 4/10s Monday through Thursday. (subject to change).
+ Pre-placement physical examination, which includes a drug screen, is required. MSTS maintains a substance abuse policy that includes random drug testing.
+ Must possess a valid driver's license.
MSTS is required by DOE directive to conduct a pre-employment drug test and background review that includes checks of personal references, credit, law enforcement records, and employment/education verifications. Applicants offered employment with MSTS are also subject to a federal background investigation to meet the requirements for access to classified information or matter if the duties of the position require a DOE security clearance. Substance abuse or illegal drug use, falsification of information, criminal activity, serious misconduct or other indicators of untrustworthiness can cause a clearance to be denied or terminated by DOE, resulting in the inability to perform the duties assigned and subsequent termination of employment. In addition, Applicants for employment must be able to obtain and maintain a DOE Q-level security clearance, which requires U.S. citizenship, at least 18 years of age. Reference DOE Order 472.2 ( , "Personnel Security". If you hold more than one citizenship (i.e., of the U.S. and another country), your ability to obtain a security clearance may be impacted.
**Department of Energy Q Clearance** (position will be cleared to this level). Reviews and tests for the absence of any illegal drug as defined in 10 CFR Part 707.4 ( , "Workplace Substance Abuse Programs at DOE Sites," will be conducted. Applicant selected will be subject to a Federal background investigation, required to participate in subsequent reinvestigations, and must meet the eligibility requirements for access to classified matter. Successful completion of a counterintelligence evaluation, which may include a counterintelligence-scope polygraph examination, may also be required. Reference 10 CFR Part 709 ( , "Counterintelligence Evaluation Program."
MSTS is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, national origin, disability, veteran status or other characteristics protected by law. MSTS is a background screening, drug-free workplace.
Annual salary range for this position is: **$119,246.40 - $181,854.40.**
Starting salary is determined based on the position market value, the individual candidate education and experience and internal equity.

Our client is a cutting-edge research and development firm dedicated to pushing the boundaries of scientific discovery. We are seeking a highly experienced and innovative Principal Data Scientist to lead complex analytical projects and drive data-driven insights within our scientific research division. This is a hybrid role, offering a blend of in-office collaboration and remote flexibility. The ideal candidate will possess exceptional skills in statistical modeling, machine learning, and have a deep understanding of scientific methodologies.

Responsibilities:

• Lead the design, development, and implementation of advanced statistical models and machine learning algorithms to analyze large, complex datasets from scientific experiments.
• Extract, clean, and transform data from diverse sources, ensuring data integrity and accuracy for analysis.
• Develop predictive models and analytical solutions to address challenging scientific questions and accelerate research breakthroughs.
• Collaborate closely with research scientists, engineers, and domain experts to understand their data needs and translate them into analytical frameworks.
• Communicate complex findings and insights clearly and effectively to both technical and non-technical stakeholders through reports, presentations, and visualizations.
• Mentor junior data scientists and contribute to the growth and development of the data science team.
• Stay current with the latest advancements in data science, machine learning, and relevant scientific fields, and evaluate their applicability to our research initiatives.
• Design and conduct A/B tests and other experimental designs to validate hypotheses and measure the impact of interventions.
• Develop and maintain data pipelines and workflows to ensure efficient data processing and analysis.
• Contribute to the strategic vision for data utilization and analytics within the organization.

Qualifications:

• Master's or Ph.D. in Data Science, Statistics, Computer Science, Physics, Biology, or a related quantitative field.
• 10+ years of professional experience in data science, with a significant focus on scientific research or R&D environments.
• Expertise in programming languages such as Python or R, and experience with relevant libraries (e.g., scikit-learn, TensorFlow, PyTorch, pandas, NumPy).
• Deep understanding of statistical modeling, machine learning techniques (e.g., regression, classification, clustering, deep learning), and experimental design.
• Experience with big data technologies (e.g., Spark, Hadoop) and database management (SQL, NoSQL).
• Excellent data visualization skills and experience with tools like Tableau, Power BI, or Matplotlib.
• Strong ability to translate complex scientific problems into solvable data science challenges.
• Exceptional communication and interpersonal skills, with the ability to influence and collaborate effectively across teams.
• Experience in a hybrid work environment and the ability to manage time effectively.

This position is located in Charlotte, North Carolina, US , requiring occasional presence in the office for collaborative sessions.

Our client, a cutting-edge research and development organization, is looking for an exceptional Principal Scientist specializing in Artificial Intelligence and Machine Learning to join their pioneering team. This is a fully remote position, enabling you to contribute your expertise from anywhere in the US. You will lead innovative research projects, focusing on the application of advanced AI/ML techniques to solve complex scientific challenges. Your role will involve developing novel algorithms, designing and conducting experiments, analyzing large datasets, and translating research findings into practical applications. You will be responsible for guiding research direction, mentoring junior scientists, and collaborating with interdisciplinary teams to push the boundaries of scientific discovery. The ideal candidate possesses a Ph.D. in a relevant field (e.g., Computer Science, Physics, Engineering, Mathematics) with a strong specialization in AI/ML, and a proven track record of impactful research publications and project leadership. Expertise in areas such as deep learning, natural language processing, computer vision, or reinforcement learning is highly desirable. You should be proficient in programming languages like Python and have experience with ML frameworks such as TensorFlow or PyTorch. Excellent analytical, problem-solving, and communication skills are critical for success. This is a unique opportunity to work on high-impact research that can shape the future of scientific advancement within a collaborative, remote-first environment. The scientific initiatives often align with the innovation ecosystem in and around **Boise, Idaho, US**, however, this role is fully remote.

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at

Job Function:

Data Analytics & Computational Sciences

Job Sub Function:

Biostatistics

Job Category:

Scientific/Technology

All Job Posting Locations:

Raritan, New Jersey, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at successful candidate will contribute to statistical services in support of manufacturing programs (a.k.a. Chemistry, Manufacturing and Control (CMC)) for all therapeutic modalities (small molecules, biologics and advanced therapies).  He/she will contribute to making informed decisions in manufacturing through his/her analytical mindset, analysis skills, experimental design suggestions and through appropriate reporting and communication of data evidence. The candidate will collaborate with cross-functional teams and with external contractors. 

Key responsibilities of the position include:

• Strategic and technical leadership both internally and externally.

• Engage in collaborative efforts with researchers on experimental design, data analysis, interpretation, and clear communication of evidence to support research, development, and product commercialization within JJIM Research & Development or related Johnson & Johnson divisions.

• Serve as a statistics representative for cross-functional and intra-department teams or working groups relating to scientific or process initiatives.

• Ensure the appropriate application of statistical methodologies tailored to each research need.

• Contribute as a lead or co-author to scientific publications and presentations presenting research findings.

• undefined

Skills and Knowledge:

•  

  Strong experiences in end‑to‑end statistical support across the product lifecycle, including analytical method development and validation, formulation development and robustness, and process development and validation—aligned with regulatory standards such as FDA, EMA, ICH, and USP

• Strong record of academic collaboration and mentorship and actively contribute to cross‑functional initiatives and scientific discussions.

• Good oral and written skills are crucial, as is the desire to learn enough of the relevant science to interact effectively.

• Exposure to modern data analysis techniques and experiences such as data visualization, robust statistics and analysis of high-dimensional data is desirable.

• Constantly eager to expand statistical, communications, and computing expertise.

• Must enjoy the process of building long-term collaborative relationships, be at ease with either a non-rigid or rigid structure to projects and be organized in handling numerous projects simultaneously.

• Participation in the external professional community is expected as well.
   

Qualifications

•  

  PhD in Statistics or related field +4 years of experience or a Master’s degree in Statistics or related Quantitative Sciences field with commensurate years of relevant experience in pharmaceutical development.

• Solid knowledge of linear mixed models, multivariate analysis, design of experiments and Bayesian statistics is essential.

• Proficiency in the R language is required with the development of automated, reproducible workflows using R Markdown and Quarto to enhance regulatory submission readiness.

• Demonstrated written, oral, and personal communication skills.

• Ability to work autonomously and within a team environment.

• Demonstrated ability to work in interdisciplinary contexts outside statistics.

• Travel up to 5% of the time.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. 

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via , internal employees contact AskGS to be directed to your accommodation resource.

The anticipated base pay range for this position is :

$115,000 - $197,800

Additional Description for Pay Transparency:

Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)). Subject to the terms of their respective policies and date of hire, Employees are eligible for the following time off benefits: Vacation –120 hours per calendar year Sick time - 40 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year Holiday pay, including Floating Holidays –13 days per calendar year Work, Personal and Family Time - up to 40 hours per calendar year Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child Condolence Leave – 30 days for an immediate family member: 5 days for an extended family member Caregiver Leave – 10 days Volunteer Leave – 4 days Military Spouse Time-Off – 80 hours  Additional information can be found through the link below. 

**Job Title:** Chromatography Principal Scientist
**Location:** Cambridge, MA
**About the Job**
Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress.
Sanofi is seeking a highly motivated individual to join our analytical group as a **Chromatography Principal Scientist** . The group is part of the synthetic platform within Global CMC Development with focus on small molecules that is striving to become an industry leader in the development of transformative medicines.
The primary responsibility of this position is to provide analytical support to the chemistry teams and to develop analytical methods mainly on small molecules using equipment including HPLC, UHPLC, GC, and potentiometry.
We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people's lives. We're also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?
**Main Responsibilities**
+ Develop specific and robust analytical methods using equipment including HPLC, UHPLC, GC, and be responsible for validating the methods when necessary
+ Analyze synthetic molecules mainly by HPLC/UHPLC, GC, potentiometry, and TLC.
+ Perform quantification of impurities
+ Perform mass balance studies
+ Design and implement analytical strategies for synthesis intermediates and raw materials
+ Develop effective collaborations with others within project teams and between analytical groups
+ Generate technical reports independently
+ Share knowledge and experience of analytical method development for synthetic molecules
+ Introduce innovative analytical approaches to facilitate optimal decision-making.
+ May serve as a project lead
**About You**
**Basic Qualifications**
+ A Master's degree or equivalent in Analytical Chemistry or related field with a minimum of 8 years, or a PhD with minimum of 5 years of experience in the pharmaceutical/biotech industry. A PhD in Analytical Chemistry is preferred.
+ Expertise in the operation of LC and GC
+ Familiarity with the operation of potentiometry titrator, and TLC from multiple manufacturers
+ Extensive experience in method development using HPLC/UPLC and GC
+ Experience in analytical method validation
+ Record of adhering to and promoting lab safety practices
+ Good communications skills
**Preferred Qualifications**
+ In-depth understanding of the separation principles of LC, GC and method development software.
+ Deep expertise in chromatography method development and trouble shoots
+ Knowledge of QbD concepts, specification setting, and cGMP, with experience in contributing to regulatory submission
+ Communicates effectively in individual and group settings and collaborate effectively in a multi-disciplinary team setting
+ Demonstrated project management skills
+ Consistent record of collaboration with scientists and other stakeholders at external enterprises
+ Advanced scientific network in the industry and academia
+ Record of patents and publications
**Why Choose Us?**
+ Bring the miracles of science to life alongside a supportive, future-focused team.
+ Discover endless opportunities to grow your talent and drive your career, whether it's through a promotion or lateral move, at home or internationally.
+ Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
+ Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks' gender-neutral parental leave.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
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**Pursue** **_progress_** **, discover** **_extraordinary_**
Better is out there. Better medications, better outcomes, better science. But progress doesn't happen without people - people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let's be those people.
At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.
Watch our ALL IN video ( and check out our Diversity Equity and Inclusion actions at sanofi.com ( !
_US and Puerto Rico Residents Only_
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally inclusive and diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; natural or protective hairstyles; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
_North America Applicants Only_
The salary range for this position is:
$122,250.00 - $176,583.33
All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs. Additional benefits information can be found through the LINK ( .
Global Terms & Conditions and Data Privacy Statement ( is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions.
With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Discover more about us visiting or via our movie We are Sanofi ( an organization, we change the practice of medicine; reinvent the way we work; and enable people to be their best versions in career and life. We are constantly moving and growing, making sure our people grow with us. Our working environment helps us build a dynamic and inclusive workplace operating on trust and respect and allows employees to live the life they want to live.
All in for Diversity, Equity and Inclusion at Sanofi - YouTube (