9,664 Scientific Director jobs in the United States

Scientific Director
**School of Medicine, Stanford, California, United States**
Research
Post Date Aug 15, 2025
Requisition #
Stanford University is one of the world's most renowned universities. Sitting in the heart of the San Francisco Bay Area among the valley's most progressive companies.
You will be working with an unparalleled leading edge community of faculty and staff that are fundamentally changing the world of health care. You will have the opportunity to influence and drive change with your innovative ideas, the ability to make a difference, and participate in human advancements. Our culture is fast paced, energetic and growing all of the time.
We offer a variety of benefits beyond traditional medical, dental, retirement and savings options:
+ Events and program for children, sports camps, tuition options
+ World class intellectual stimulation through learning and development classes, workshops and onsite conferences from leading edge speakers and faculty
+ Work/life and family friendly policies and reimbursement
+ Participation in Stanford's social responsibility and sustainable programs for a better world
+ A vibrant university culture that values the uniqueness of each individual
We are seeking candidates who are expert organizers, compliance gurus, and still have a spirit and energy to change the world.
About the Position:
Stanford University is seeking a Research Technical Manager 1 provide management and coordination of administrative and operations related functions for assigned research area(s) engaged in developing, advancing and applying sciences, engineering and technical research to innovate and deliver solutions in support of organizational goals. Manage staff at least 50% of the time to achieve the research and teaching mission, goals and objectives of the unit. Partner with faculty leadership on departmental affairs.
This position is for a Scientific Director will work directly with Prof. William Greenleaf to catalyze RNA medicine program at Stanford. They will coordinate effective and timely communications, track milestones, interface with funders, facilitate annual reviews and Management Group meetings, ensure timely publications, data availability, proper IP management, and support pre-clinical research activities. Also facilitate the transfer of reagents, data, and information among team members. They will work with faculty investigators, and Host Institutions for federal and foundation award. They will work with each Host Institution and Co -Investigators to track budgets and ensure appropriate deployment of resources.
Duties include:
+ Provide strategic planning for own work group; participate with senior managers in higher level strategic planning. Communicate operational objectives and assignments and delegate to staff.
+ Manage the daily operations of an assigned area(s) which include recruiting, hiring, training, developing evaluating and setting priorities of staff, coordinate business, technical, and educational activities for direct reports.
+ Oversee interdepartmental activities, projects and efforts by applying advanced technical and professional knowledge. Serve as the initial managerial escalation point for problems from clients and other staff.
+ Manage project budgets, schedules, and resources. Oversee preparation of periodic financial and technical reports and operating plans.
+ Interface with clients to determine project requirements. Establish service level agreements with clients.
+ Monitor scientific, engineering, and/or technology trends and evaluate emerging technologies to recommend for adoption and implementation.
+ Communicate and implement policies, procedures, best practices, recommendations and guidelines compliance with established University administrative policies and procedures.
_* - Other duties may also be assigned._
DESIRED QUALIFICATIONS:
Ph.D. in Molecular Biology or related field. Five plus year experience in RNA science, program development.
EDUCATION & EXPERIENCE (REQUIRED):
Bachelor's degree and five years of relevant experience, or combination of education and relevant experience. Advanced degree may be required.
KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
+ Experience leading or overseeing the work of technical staff.
+ Understanding of relevant scientific, engineering, or technical disciplines.
+ Ability to problem solve.
+ Ability to synthesize and articulate technical and scientific methodologies, specifications, and information.
+ Experience leading scientific, engineering, or technical research projects or programs.
+ Knowledge of emerging technologies, trends, methodologies, and resource management principles.
+ Ability to work and communicate effectively with others.
+ Strong customer relationship and consensus building skills.
+ Ability to influence and establish effective working relationships in a diverse environment.
+ Ability to resolve issues quickly and make decisions that meet university objectives in a collaborative culture.
CERTIFICATIONS & LICENSES:
None.
PHYSICAL REQUIREMENTS*:
+ Frequently sit, grasp lightly, use fine manipulation and perform desk-based computer tasks, lift, carry, push pull objects that weigh to ten pounds.
+ Occasionally sit, use a telephone or write by hand.
+ Rarely kneel, crawl, climb, twist, bend, stoop, squat, reach or work above shoulders, sort, file paperwork or parts, operate foot and hand controls.
_* - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job._
WORKING CONDITIONS:
May require extended hours, evenings and weekends.
WORK STANDARDS (from JDL):
+ Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
+ Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.
+ Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, expected pay range for this position is $145,208 to $183,215 per annum. Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs.
At Stanford University, base pay represents only one aspect of the comprehensive rewards package. The Cardinal at Work website ( provides detailed information on Stanford's extensive range of benefits and rewards offered to employees. Specifics about the rewards package for this position may be discussed during the hiring process.
The job duties listed are typical examples of work performed by positions in this job classification and are not designed to contain or be interpreted as a comprehensive inventory for all duties, tasks, and responsibilities. Specific duties and responsibilities may vary depending on department or program needs without changing the general nature and scope of the job or level of responsibility. Employees may also perform other duties as assigned.
Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
Additional Information
+ **Schedule: Full-time**
+ **Job Code: 4986**
+ **Employee Status: Regular**
+ **Grade: L**
+ **Department URL:** ** **Requisition ID: **
+ **Work Arrangement : On Site**

**Work Schedule**
Standard (Mon-Fri)
**Environmental Conditions**
Laboratory Setting, Office, Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)
**Job Description**
**About Us:**
At Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our PPD® Laboratory Services team and contribute to improving patient health. Our world-leading scientists and experts deliver groundbreaking innovations with a commitment to accuracy and quality.
**Role Summary:**
The Scientific Director of Laboratory Services is responsible for directing, planning, and managing the scientific and medical quality of the technical department. This role involves working closely with scientists and medical laboratory scientists to develop and optimize clinical assays. The Director provides expert advice to management and technical personnel on development technologies and activities and is accountable for the quality and timeliness of projects involving themselves or their colleagues.
**Role Responsibilities:**
+ Select and validate test methods, monitor quality control, and ensure compliance with quality and licensing regulations.
+ Review corrective and preventative action plans, safety procedures, and Standard Operating Procedures (SOPs).
+ Provide clinical consultations to laboratory clients and ensure test results include all pertinent information for accurate interpretation.
+ Direct research and development of new assays, troubleshoot and improve current assays, and participate in continuous improvement efforts.
+ Assist in the formulation of sales and marketing objectives, identify new clients and services, and represent the organization to the scientific community.
+ Oversee laboratory operations, ensuring compliance with SOPs and client requirements.
+ Manage project contracts, scope, pricing, and client interactions.
+ Lead and develop staff, including hiring, performance management, and professional development.
+ Ensure financial goals are met through strategic planning and project management.
+ Provide medical consultation, assess adverse events, and ensure safety during clinical trials.
**Qualifications:**
+ Earned doctoral degree (e.g., Ph.D., Sc.D.) in a relevant chemical, physical, or biological science major from an accredited institution.
+ Board certified, or eligible with relevant training/working experience
+ 12+ years of experience leading multi-departmental clinical or analytical laboratories and developing and executing protocols. Or equivalent and relevant combination or education, training, & experience that provides the knowledge, skills, and abilities to perform the job.
_Years of experience refers to typical years of related experience needed to gain the required knowledge, skills, and abilities necessary to perform the essential functions of the job. Years of experience are not to be used as the only determining factor in establishing the job class or making employment selection decisions_
**Working Environment:**
+ Work is performed in an office, laboratory, and/or clinic environment with exposure to electrical office equipment.
+ Frequently drives to site locations, frequently travels within the United States, occasional international travel.
+ Rare exposure to biological fluids, potential exposure to infectious organisms.
+ Personal protective equipment is required frequently, such as protective eyewear, garments, and gloves.
+ Exposure to fluctuating and/or extreme temperatures on rare occasions.
Apply now to be part of a team that is at the forefront of scientific innovation!
Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.

**Work Schedule**
Standard (Mon-Fri)
**Environmental Conditions**
Laboratory Setting, Office, Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)
**Job Description**
**About Us:**
At Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our PPD® Laboratory Services team and contribute to improving patient health. Our world-leading scientists and experts deliver groundbreaking innovations with a commitment to accuracy and quality.
**Role Summary:**
The Scientific Director of Laboratory Services is responsible for directing, planning, and managing the scientific and medical quality of the technical department. This role involves working closely with scientists and medical laboratory scientists to develop and optimize clinical assays. The Director provides expert advice to management and technical personnel on development technologies and activities and is accountable for the quality and timeliness of projects involving themselves or their colleagues.
**Role Responsibilities:**
+ Select and validate test methods, monitor quality control, and ensure compliance with quality and licensing regulations.
+ Review corrective and preventative action plans, safety procedures, and Standard Operating Procedures (SOPs).
+ Provide clinical consultations to laboratory clients and ensure test results include all pertinent information for accurate interpretation.
+ Direct research and development of new assays, troubleshoot and improve current assays, and participate in continuous improvement efforts.
+ Assist in the formulation of sales and marketing objectives, identify new clients and services, and represent the organization to the scientific community.
+ Oversee laboratory operations, ensuring compliance with SOPs and client requirements.
+ Manage project contracts, scope, pricing, and client interactions.
+ Lead and develop staff, including hiring, performance management, and professional development.
+ Ensure financial goals are met through strategic planning and project management.
+ Provide medical consultation, assess adverse events, and ensure safety during clinical trials.
**Qualifications:**
+ Earned doctoral degree (e.g., Ph.D., Sc.D.) in a relevant chemical, physical, or biological science major from an accredited institution.
+ Board certified, or eligible with relevant training/working experience
+ 12+ years of experience leading multi-departmental clinical or analytical laboratories and developing and executing protocols. Or equivalent and relevant combination or education, training, & experience that provides the knowledge, skills, and abilities to perform the job.
_Years of experience refers to typical years of related experience needed to gain the required knowledge, skills, and abilities necessary to perform the essential functions of the job. Years of experience are not to be used as the only determining factor in establishing the job class or making employment selection decisions_
**Working Environment:**
+ Work is performed in an office, laboratory, and/or clinic environment with exposure to electrical office equipment.
+ Frequently drives to site locations, frequently travels within the United States, occasional international travel.
+ Rare exposure to biological fluids, potential exposure to infectious organisms.
+ Personal protective equipment is required frequently, such as protective eyewear, garments, and gloves.
+ Exposure to fluctuating and/or extreme temperatures on rare occasions.
Apply now to be part of a team that is at the forefront of scientific innovation!
Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge.
**Job Description**
At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide.
**_Objective / Purpose:_**
This role will play a pivotal role in discovering first-/best-in-class small molecules, bifunctional degraders, and RNA/oligonucleotides by leveraging computational chemistry and cheminformatics methods to design molecules as well as providing scientific mentoring and leadership to junior members of the team. The person will be tightly integrated into the computational chemistry team and also provide timely and innovative designs and support to our drug discovery programs. Additionally, the role will collaborate closely with global chemistry, structural biology, DMPK, and safety experts for molecular design and help to define a roadmap for computational tools that empower medicinal chemists in their design efforts. While the role will focus on a specific set of programs at any point in time, the drug discovery programs span Takeda's therapeutic areas, including oncology, neuroscience, gastroenterology, and inflammation.
**_Accountabilities:_**
+ Co-design molecules for several drug discovery programs across various modalities including small molecules, molecular glues, degraders, and RNA/oligonucleotides
+ Demonstrate expert understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment
+ Provide crucial technical knowledge and input to project teams to drive decision-making in drug discovery projects by applying in-depth knowledge of structure-activity relationships (SAR), target biology, and predictive methods for assessing on- and off-target activity, physical properties, pharmacokinetics / pharmacodynamics (PK/PD), and synthetic feasibility
+ Implement and execute innovative computational methodologies and tools such as AI-based drug discovery, state-of-the-art commercial and open-source software tools/methods
+ Mentor junior computational chemists on molecular design best practices
+ Open to traveling and spending time on both sites as required
+ Serve as a trusted thought partner, helping to drive ideation and execution of innovative chemistry strategies that meet Takeda's therapeutic goals
**_Education & Competencies (Technical and Behavioral):_**
The ideal candidate will have demonstrated experience impacting drug discovery exemplified by delivering molecules to the clinic, leveraging cutting-edge physics-based modeling, AI/ML-driven approaches, and generative chemistry, collaborating effectively with biologists, structural biologist, pharmacologists, DMPK scientists as well as leading and mentoring computational chemistry teams.
- PhD in Computational Chemistry, Chemical Physics, Medicinal Chemistry, or related disciplines, with 20+ years of experience in pharmaceutical or biotech
- Deep expertise in structure-based design, ligand-based design, and cheminformatics with a strong background in medicinal chemistry principles
- Proven track record in using computational methods to drive small molecule drug discovery, from hit identification to clinical candidate selection
- Extensive knowledge of computational chemistry tools, including docking, molecular dynamics, FEP, QSAR modeling, and generative AI
- Strong programming and scripting skills (e.g., Python, R, C/C++) with experience in building and automating computational workflows
- Strong publication record demonstrating innovative contributions to computational chemistry and drug discovery
**ADDITIONAL INFORMATION:**
+ The position will be based in Cambridge, MA.This position is currently classified as "hybrid" by Takeda's Hybrid and Remote Work policy.
**Takeda Compensation and Benefits Summary**
We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
**For Location:**
Boston, MA
**U.S. Base Salary Range:**
$208,200.00 - $327,140.00
The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
**EEO Statement**
_Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law._
**Locations**
Boston, MA
**Worker Type**
Employee
**Worker Sub-Type**
Regular
**Time Type**
Full time
**Job Exempt**
Yes
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

The **Clinical Imaging Scientific Director for Oncology** will own the strategy and execution of complex early through late-phase oncology imaging in clinical trials where imaging plays a key role. Imaging includes all modalities with a special focus on PET and CT. In this role, you will champion the development of imaging endpoints and biomarkers and drive the scientific imaging aspects as well as tumor response assessment of oncology clinical studies in partnership with clinical sciences and preclinical research teams.
**In this role, a typical day might include the following:**
+ Create fit-for-purpose imaging biomarker strategies and work closely with research, clinical imaging and the oncology therapeutic area for the development of imaging endpoints to inform and advance the Regeneron clinical pipeline.
+ Prepare and present clinical imaging strategies to senior management.
+ Manage a complex network of stakeholders across Regeneron.
+ Lead, design and implement multi-modality imaging measures as endpoints for oncology therapeutic clinical studies.
+ Collaborate closely with Regeneron clinical teams as imaging subject matter expert to ensure optimal design and execution of imaging strategy including development of protocols, imaging endpoints, imaging manuals, imaging charters, statistical analysis plans and clinical study reports.
+ Work closely with Clinical Imaging Operations and imaging contract research organizations to ensure the flawless conduct and data integrity of studies' imaging components and endpoints.
+ Serve as Study Scientific Director for clinical trials focused on qualification and utilization of novel imaging biomarkers.
+ Lead the interaction with regulatory agencies for communications regarding imaging endpoints and procedures.
+ Lead the interaction with regulatory agencies and site ethic committees for approval of clinical imaging biomarker development studies
**This Job Might Be For You If You Have:**
+ Experience as study scientific director of PET imaging biomarker clinical trials in Oncology.
+ Experience applying PET imaging as a quantitative endpoint in clinical and preclinical studies in Oncology.
+ People management experience.
+ Direct experience with preclinical oncology imaging models using PET and immuno-PET imaging biomarkers.
+ Strong background in oncology, biology, molecular imaging, radiopharmceuticals and familiar with precision medicine approaches.
+ Imaging CRO oversight and implementation of quality control procedures.
**To be considered for this role, you must have** a PhD with a minimum of 10+ years of clinical imaging experience (minimum of 7 years within oncology drug development). **Experience** **implementing central efficacy assessments using tumor response criteria such as RECIST 1.1, iRECIST, PCWG3, Lugano and IMWG in oncology clinical trials** **is required** . We also are looking for you to have had successful engagement experience with regulatory agencies and the ability to champion imaging innovations and lead projects effectively.
Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.
For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.
Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.
**Salary Range (annually)**
$202,000.00 - $336,600.00

**About Us:**
The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe.
**Role Overview:**
The Department of Pathology and Laboratory Medicine at MSK is seeking an outstanding faculty candidate at the level of Assistant, Associate, or full Member to fill a position dedicated to development and clinical operationalization of next-generation sequencing (NGS) methods for cancer diagnosis and treatment selection. MSK is one of the world's premier cancer centers, committed to exceptional patient care and leading-edge research. To enable large-scale tumor genomic characterization and facilitate enrollment to precision oncology clinical trials, we have implemented several innovative NGS-based assays as part of our world-leading clinical genomics program, including MSK-IMPACT for tumor tissue and MSK-ACCESS for circulating tumor DNA. MSK-IMPACT was the first tumor profiling test to be cleared by the US Food & Drug Administration and has been used as part of the clinical care of >100,000 MSK patients. MSK-ACCESS is approved by the NY State Department of Health and has been used for non-invasive liquid biopsy testing of >15,000 MSK patients. Newer tests for rapid genomic profiling and whole transcriptome RNA sequencing have also been approved and implemented. All clinical NGS testing is jointly operationalized by the Molecular Diagnostics Service and the Clinical Computational Diagnostics Service and performed by a collaborative team of pathologists, laboratory scientists, computational biologists, and administrative personnel.
- Oversee the clinical validation and implementation of NGS-based diagnostic tests within the Diagnostic Molecular Pathology Laboratory.
- Design and develop new clinical tests to address emerging clinical needs in accordance with institutional strategic priorities.
- Serve as a technical resource to laboratory staff for experimental design, protocol development, and troubleshooting.
- Pilot novel technologies, processes, automation methods, and QA procedures across high-throughput nucleic acid extraction, sample preparation, and next-generation sequencing teams.
- Partner with medical directors, bioinformatics teams, and departmental and service leadership to develop and execute MSK's clinical genomics strategy to support clinical research and patient care.
- Drive and sustain a culture of continuous innovation and improvement.
**Key Qualifications:**
+ Have a PhD or MD or equivalent degree.
+ Have expertise in next-generation sequencing technology, nucleic acid extraction, and high-throughput laboratory automation.
+ Be a problem solver who can manage complex information to effectively solve problems in collaboration with diverse teams.
**Core Skills:**
We are searching for a Scientific Director of Clinical NGS to oversee assay development and laboratory operations across the areas of nucleic acid extraction, sample preparation, next-generation sequencing, and laboratory automation, in partnership with the Medical Laboratory Directors and Service and Departmental leadership. Expertise in next-generation sequencing technology and nucleic acid extraction is required. Experience with high-throughput laboratory automation and a strong scientific background and a track record in clinical assay development is desired. Applicants must have a PhD, MD or equivalent degree.
**_Pa_** **_y Range_** _:_ $200,000 - $00,000
**Application Instructions**
Please send a CV and letter outlining your interest to:
Kojo Elenitoba-Johnson, M.D.
Chairman, Department of Pathology
Memorial Sloan-Kettering Cancer Center
1275 York Avenue
New York, NY 10065
Email:
**Helpful links:**   
+ MSK Compensation Philosophy ( Review Our Great Benefits Offerings
Pay Range: $0.0 - 10,000,000.00
FSLA Status: Exempt
**Closing** :
At MSK, we believe in fair, competitive pay that reflects your job, experience, and skills.
MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.
Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please tell us if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
Lilly's Biotechnology Discovery Research (BioTDR) organization has a track record for delivering novel biotherapeutic medicines advanced into clinical research in key areas of unmet medical needs, across a variety of therapeutic areas. Integrating biology with innovative scientific capabilities in protein discovery, engineering and computational sciences, we are committed to delivering next wave of biomedicines.
We are seeking an accomplished scientific leader to drive the development of next-generation computational platforms for therapeutic antibody discovery. This role will lead the design and implementation of NGS-centric bioinformatics pipelines and machine learning models to accelerate in silico and de novo antibody discovery, directly impacting our large molecule drug discovery pipeline.
The ideal candidate brings deep expertise in antibody repertoire sequencing, structural modeling, and ML/AI driven antibody engineering, combined with strong leadership and cross-functional collaboration experience.
**Key Responsibilities:**
+ Establish integrated NGS pipeline and databases for efficient large-scale antibody repertoire analysis.
+ Develop and apply bioinformatics and machine learning models to enable in silico and de novo antibody discovery, leveraging insight from natural B cell affinity maturation.
+ Integrate structure-based prediction methods and antibody LLM to identify and optimize novel antibodies against challenging targets.
+ Design scalable computational infrastructure to enable large-scale model training, data integration, and production workflows.
+ Partner with wet-lab discovery, protein engineering, information technologist and therapeutic area teams to translate computational insights into validated antibody leads.
+ Lead and mentor a high-performing team of computational scientists and bioinformaticians.
+ Drive cross-functional collaborations and represent the organization in external partnerships, scientific presentations, and publications.
**Qualifications:**
+ Ph.D. in Bioinformatics, Immunology, Computational Biology or related field.
+ 4+ years of experience (academic or industry) in computational antibody discovery, biologics R&D, or related field.
**Preferred** :
+ Proven expertise in NGS-based antibody repertoire sequencing and analysis.
+ Proficiency in Python, deep learning frameworks, and bioinformatics pipeline development.
+ Experience designing and managing large-scale computational infrastructure (on-premises and cloud-based).
+ Demonstrated leadership experience managing scientific teams and cross-functional projects.
+ Strong communication skills with a proven track record of scientific publications and external presentations.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$184,500 - $270,600
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
Lilly's Drug Metabolism and Pharmacokinetics (DMPK) team is searching for an experienced pharmaceutical scientist to lead the application of absorption, distribution, metabolism, excretion (ADME) science to advance our portfolio. Working on cross-functional teams, our diverse group is multidisciplinary, applying in vitro, in vivo, and in silico approaches to mechanistically study the pharmacokinetics, absorption, and disposition of biologics/antibodies. You will serve as technical leader within the department and across portfolio cross-functional teams. This role will require engaging in experimental design and data interpretation to deliver the discovery and development portfolio of investigational targets and novel therapeutics. We are passionate about making an impact in the lives of our patients. Consider joining our efforts!
Responsibilities:
- Accountable for the delivery of scientifically integrated data packages to guide compound selection, study design, portfolio decisions, and regulatory submissions.
- Partner with cross-functional colleagues in both Discovery and Development (eg. Toxicology, Pharmacology, Chemistry, Clinical PK/PD, Clinical Pharmacology, Regulatory, and Medical) to assess drugability and optimize ADME properties to deliver drug candidates to the clinic, as well as to design and support nonclinical and clinical studies, supporting global registration packages.
- Lead R&D initiatives to grow and develop ADME/DMPK capabilities for across experimental and drug modalities including biologics/antibodies.
- Integrate in vitro, in vivo, and in silico ADME data with Biology and Chemistry understanding to define structure-activity- and structure-property-relationships and deliver favorable molecular and experimental design strategies.
- Prepare data packages and develop content in regulatory documents (eg. IB, IND, IMPD, NDA/BLA, etc.) to support global regulatory submissions (including sections 2.6.4./non-clinical pharmacokinetics and 2.7.2./clinical pharmacology) and correspondence as well as represent ADME in face-to-face discussions with regulators.
- Guide junior, peer, and upper level scientists in best and modern practices of multi-property optimization through the use of mechanistic ADME principles.
- Effectively partner to apply innovative PBPK approaches to translate and predict human PK, inform clinical plans and support registration.
- Communicate the value of mechanistic ADME approaches both internally within R&D and externally including regulatory agencies.
- Build a strong external network (e.g. academia, consortia) and keep up to date with emerging literature and science in the area.
Basic Qualifications:
Ph.D. degree in Pharmacokinetics, Pharmacology, Pharmaceutics, Biochemistry, or related field with 6 years or more of extensive training in the field of drug metabolism and disposition or clinical pharmacology.
Additional Skills/ Preferences:
- Experience in drug discovery and development across a variety of therapeutic areas.
- Experience with biologics/antibodies.
- Detailed understanding of pharmacokinetics, ADME, drug interactions and proficiency to communicate theory and concepts clearly.
- Ability to balance multiple projects and handle competing responsibilities.
- Experience with modeling software (e.g. SimCYP, GastroPlus, NONMEM, Matlab, etc.).
- Demonstrate strong communication skills with the ability to integrate diverse perspectives, adroitly deliver critical messaging, and influence leaders/key partners.
- Collaborative team behaviors and aspiration to build and sustain relationships with R&D customers and the wider scientific community.
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Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$168,000 - $294,800
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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