40,675 Senior Software Engineer jobs in the United States

The Position

A healthier future. Its what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. Thats what makes us Genentech.

The Opportunity

At Genentech and Roche, we're at the forefront of a revolutionary transformation in drug discovery powered by AI and machine learning. Our "lab in the loop" strategy processes massive quantities of experimental data to train AI models that accelerate the discovery of new medicines.

To enable this vision, we're seeking exceptional Senior Software Development Engineers to be part of the team building and maintaining our next-generation Therapeutic Molecule Registration (TMR) platform - a foundational component of our AI-driven drug discovery infrastructure.

This platform will serve as the central nervous system for managing and integrating molecular data across our global research organization, handling hundreds of billions of records and enabling unprecedented scale in virtual molecule design and testing. As the volume of AI-generated molecular designs grows exponentially, our TMR platform must evolve to become a high-performance, cloud-native system capable of supporting rapid iteration cycles between computational design and experimental validation. You will be instrumental in consolidating our molecule registration systems into a single, harmonized environment, unlocking the full potential of our data and accelerating the development of life-changing therapies.

In the role, you will:

• You will combine software engineering expertise with an interest in chemical and biological data management systems.
• You will work closely with Genentech Computational Sciences (gCS) colleagues, including our machine learning for drug development team, Genentech Research & Early Development (gRED) Drug Discovery teams including the Antibody Engineering division, and other teams across the Roche family of companies to identify, strategize, and productionalize high-impact applications from across the drug discovery and development pipeline.
• You will develop and maintain core features of our TMR platform.
• You will write high-quality, testable code for chemical registration workflows.
• You will design and implement RESTful APIs and microservices.
• You will contribute to technical design discussions and architecture decisions.

Who you are

Software Development Engineer

• Bachelor's degree in Computer Science or related field (or equivalent experience).
• 3+ years of software engineering experience.
• Strong Python programming skills.
• Basic Java/Kotlin knowledge.
• Experience with SQL databases.
• Understanding of REST APIs.
• Strong testing practices.
• Cloud platform exposure (preferably AWS).

Senior Software Development Engineer

• Bachelor's degree in Computer Science or related field (or equivalent experience).
• 7+ years of software engineering experience.
• Strong Python programming skills.
• Ability to work with Java/Kotlin codebases.
• Working knowledge of Postgres and SQL.
• Experience with REST APIs and microservices.
• Strong testing practices and test automation.
• Experience with cloud platforms (preferably AWS).
• Understanding of CI/CD pipelines.
• Experience with agile development methodologies.

Expected Salary Range

The expected salary range for this position based on the location of New York is $110,200 - 204,600, or California is $115,200 - 214,000 of hiring range. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Preferred experience for both levels

• Open source cheminformatics experience (e.g., RDKit, chemfp, Indigo, HELM toolkit).
• Chemical database cartridge expertise.
• Familiarity with biological sequence alignment.
• Chemical & biological structure notation expertise.
• Familiarity with chemical structure canonicalization.
• Molecular structure searching algorithm expertise.
• Experience with scientific software development.
• Familiarity with Docker and Kubernetes.
• Experience with event-driven architectures.
• Knowledge of security best practices.

Relocation benefits are available for this job posting.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

The Position A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Roche. Advances in AI, data, and computational sciences are transforming drug discovery and development. Roche's Research and Early Development organisations at Genentech (gRED) and Pharma (pRED) have demonstrated how these technologies accelerate R&D, leveraging data and novel computational models to drive impact. Seamless data sharing and access to models across gRED and pRED are essential to maximising these opportunities. The new Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness the transformative power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative medicines for patients worldwide. The Opportunity At Genentech and Roche, we're at the forefront of a revolutionary transformation in drug discovery powered by AI and machine learning. Our "lab in the loop" strategy processes massive quantities of experimental data to train AI models that accelerate the discovery of new medicines. To enable this vision, we're seeking exceptional Senior Software Development Engineers to be part of the team building and maintaining our next-generation Therapeutic Molecule Registration (TMR) platform - a foundational component of our AI-driven drug discovery infrastructure. This platform will serve as the central nervous system for managing and integrating molecular data across our global research organization, handling hundreds of billions of records and enabling unprecedented scale in virtual molecule design and testing. As the volume of AI-generated molecular designs grows exponentially, our TMR platform must evolve to become a high-performance, cloud-native system capable of supporting rapid iteration cycles between computational design and experimental validation. You will be instrumental in consolidating our molecule registration systems into a single, harmonized environment, unlocking the full potential of our data and accelerating the development of life-changing therapies. In the role, you will: You will combine software engineering expertise with an interest in chemical and biological data management systems. You will work closely with Genentech Computational Sciences (gCS) colleagues, including our machine learning for drug development team, Genentech Research & Early Development (gRED) Drug Discovery teams including the Antibody Engineering division, and other teams across the Roche family of companies to identify, strategize, and productionalize high-impact applications from across the drug discovery and development pipeline. You will develop and maintain core features of our TMR platform You will write high-quality, testable code for chemical registration workflows You will design and implement RESTful APIs and microservices You will contribute to technical design discussions and architecture decisions Who you are Software Development Engineer Bachelor's degree in Computer Science or related field (or equivalent experience) 3+ years of software engineering experience Strong Python programming skills Basic Java/Kotlin knowledge Experience with SQL databases Understanding of REST APIs Strong testing practices Cloud platform exposure (preferably AWS) The expected salary range for this position based on the location of New York is $110,200 - 204,600, or California is $15,200 - 214,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Senior Software Development Engineer Bachelor's degree in Computer Science or related field (or equivalent experience) 7+ years of software engineering experience Strong Python programming skills Ability to work with Java/Kotlin codebases Working knowledge of Postgres and SQL Experience with REST APIs and microservices Strong testing practices and test automation Experience with cloud platforms (preferably AWS) Understanding of CI/CD pipelines Experience with agile development methodologies The expected salary range for this position based on the location of New York is 136,300 - 253,100, or California is 142,500 - 264,7000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Preferred experience for both levels Open source cheminformatics experience (e.g., RDKit, chemfp, Indigo, HELM toolkit) Chemical database cartridge expertise Familiarity with biological sequence alignment Chemical & biological structure notation expertise Familiarity with chemical structure canonicalization Molecular structure searching algorithm expertise Experience with scientific software development Familiarity with Docker and Kubernetes Experience with event-driven architectures Knowledge of security best practices Relocation benefits are available for this job posting Benefit #ComputationCoE #tech4lifeComputationalScience Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants. #J-18808-Ljbffr

Every day, tens of millions of people come to Roblox to explore, create, play, learn, and connect with friends in 3D immersive digital experiences- all created by our global community of developers and creators.

At Roblox, we're building the tools and platform that empower our community to bring any experience that they can imagine to life. Our vision is to reimagine the way people come together, from anywhere in the world, and on any device.We're on a mission to connect a billion people with optimism and civility, and looking for amazing talent to help us get there.

A career at Roblox means you'll be working to shape the future of human interaction, solving unique technical challenges at scale, and helping to create safer, more civil shared experiences for everyone.

What You'll Do:

In this Frontend Architect role, you will be a key contributor in shaping the future of Roblox's application surfaces. You will develop the architecture and technical direction of our frontend stack for consumer-facing surfaces, working across teams and technology platforms to ensure our solutions are universal and scalable. This role would require defining how all our frontend pieces fit together, how data flows through the client, and how we can build features faster and more reliably. You will have the opportunity to work with modern frameworks and also dive into our custom Luau-based tech, bridging the best ideas from the web ecosystem into Roblox's unique environment. If you are excited by the idea of creating the foundation on which dozens of engineers will build new features - and doing it in a way that delights our end-users with speed and stability - then this role will be perfect for you.

Join us and help build the frontend platform that underpins the metaverse! Together, we'll enable incredible new experiences for our users and a productive, joyful development experience for our engineers.
You Have:

• Bachelor's degree in Computer Science or a related field, or equivalent practical experience.
• 8+ years of software development experience, including substantial experience building user-facing frontend applications. Proven track record in implementing or architecting complex frontend systems for large-scale applications (experience with large-scale or high-traffic applications is a plus).
• Deep expertise in modern mobile/web/frontend technologies - including proficiency in HTML5, CSS3, and JavaScript/TypeScript or mobile equivalents - and hands-on experience with frameworks such as React. Comfortable with component-based architecture and state management patterns (Redux/Flux or similar) for building maintainable UIs.
• Strong programming skills in one or more scripting languages relevant to frontend and tooling such as TypeScript, Swift or Kotlin, or the ability to quickly learn them, is highly desirable. Familiarity with C++ or other low-level languages is beneficial for understanding our engine integration.
• Solid understanding of software design principles and architectural patterns as they apply to frontend development. Able to design clean APIs and module boundaries, and experienced in creating maintainable and testable code bases with proper unit/integration testing practices.
• Demonstrated ability to optimize frontend performance and diagnose issues. Knowledge of performance debugging, profiling, and benchmarking techniques on the client side. Passion for ensuring fast, fluid user experiences on all devices.
• Excellent communication skills and a team-oriented mindset. Ability to work effectively with cross-functional teams, gather requirements, and drive consensus on technical solutions. Comfortable sharing ideas, documenting designs, and collaboratively solving problems in a large engineering organization.
• Experience developing applications or libraries across multiple platforms (web, mobile, desktop). Familiarity with building applications that serve users on Web, iOS, Android, Windows, etc. is desirable for ensuring a seamless cross-platform experience.

• Design and implement robust, extensible systems powering Roblox's core surfaces (Home, Avatar, Search, etc.) to serve millions of users efficiently.
• Create reusable frontend abstractions using React paradigms and modern tech to enable fast, consistent UI development across teams and devices.
• Maintain and evolve Roblox's internal React-inspired Luau UI libraries, promoting modular design, state management patterns, and performance.
• Define architecture standards to ensure frontend code is scalable, testable, and aligned with proven patterns like Flux, MVC, and MVVM.
• Partner with engineering, product, and design teams to integrate shared solutions and deliver cohesive, high-quality user experiences.
• Address cross-surface issues like memory, responsiveness, and load times to ensure a reliable, fast UI at scale.
• Provide architectural leadership, review designs/code, and mentor engineers in best practices and effective use of platform tools.